Q9BEA9 (GSTM3_MACFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase Mu 3
EC=2.5.1.18

Alternative name(s):
GST class-mu 3
GSTM3-3

Gene names

Name:

GSTM3

Organism

Macaca fuscata fuscata (Japanese macaque)

Taxonomic identifier

9543 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca › Macaca fuscata

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Mu family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Glutathione S-transferase Mu 3		PRO_0000185823
Regions
	Domain	5 – 92	88	GST N-terminal
	Domain	94 – 212	119	GST C-terminal
	Region	11 – 12	2	Glutathione binding By similarity
	Region	50 – 54	5	Glutathione binding By similarity
	Region	63 – 64	2	Glutathione binding By similarity
	Region	76 – 77	2	Glutathione binding By similarity
Sites
	Binding site	120	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BEA9 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 675126079D89398A	FASTA	225	26,604
	10 20 30 40 50 60 MSCESSMVLG YWDIRGLAHA IRLLLEFTDT SYEEKRYTCG EAPDYDRSQW LDVKFKLDLD 70 80 90 100 110 120 FPNLPYLMDG KNKITQSNAI LRYIARKHNM CGETEEEKIR VDIIENQVMD FRTQLIRLCY 130 140 150 160 170 180 SSDHEKLKPQ YLEELPGQLK QFSVFLGKFS WFAGEKLTFV DFLTYDILDQ NRIFEPKCLD 190 200 210 220 EFPNLKAFMC RFEALEKIAA YIQSDQFFKM PINNKMAQWG NKPVC

References

[1]	"Macaca fuscata glutathione transferase M3." Beuckmann C.T., Fujimori K., Urade Y. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB025800 mRNA. Translation: BAB40443.1.
3D structure databases
ProteinModelPortal	Q9BEA9.
SMR	Q9BEA9. Positions 2-225.
ModBase	Search...
Proteomic databases
PRIDE	Q9BEA9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106842.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003081. GST_mu. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01267. GSTRNSFRASEM.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTM3_MACFU

Accession

Primary (citable) accession number: Q9BEA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 23, 2007
Last modified:	March 6, 2013
This is version 52 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program