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Q9BEA9 (GSTM3_MACFU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase Mu 3

EC=2.5.1.18
Alternative name(s):
GST class-mu 3
GSTM3-3
Gene names
Name:GSTM3
OrganismMacaca fuscata fuscata (Japanese macaque)
Taxonomic identifier9543 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Glutathione S-transferase Mu 3
PRO_0000185823

Regions

Domain5 – 9288GST N-terminal
Domain94 – 212119GST C-terminal
Region11 – 122Glutathione binding By similarity
Region50 – 545Glutathione binding By similarity
Region63 – 642Glutathione binding By similarity
Region76 – 772Glutathione binding By similarity

Sites

Binding site1201Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9BEA9 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 675126079D89398A

FASTA22526,604
        10         20         30         40         50         60 
MSCESSMVLG YWDIRGLAHA IRLLLEFTDT SYEEKRYTCG EAPDYDRSQW LDVKFKLDLD 

        70         80         90        100        110        120 
FPNLPYLMDG KNKITQSNAI LRYIARKHNM CGETEEEKIR VDIIENQVMD FRTQLIRLCY 

       130        140        150        160        170        180 
SSDHEKLKPQ YLEELPGQLK QFSVFLGKFS WFAGEKLTFV DFLTYDILDQ NRIFEPKCLD 

       190        200        210        220 
EFPNLKAFMC RFEALEKIAA YIQSDQFFKM PINNKMAQWG NKPVC 

« Hide

References

[1]"Macaca fuscata glutathione transferase M3."
Beuckmann C.T., Fujimori K., Urade Y.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB025800 mRNA. Translation: BAB40443.1.

3D structure databases

ProteinModelPortalQ9BEA9.
SMRQ9BEA9. Positions 2-225.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9BEA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106842.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01267. GSTRNSFRASEM.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTM3_MACFU
AccessionPrimary (citable) accession number: Q9BEA9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 53 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families