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Protein

NF-kappa-B inhibitor zeta

Gene

NFKBIZ

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor zeta
Alternative name(s):
I-kappa-B-zeta
Short name:
IkB-zeta
Short name:
IkappaBzeta
Molecule possessing ankyrin repeats induced by lipopolysaccharide
Short name:
MAIL
Gene namesi
Name:NFKBIZ
Synonyms:MAIL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:32050 NFKBIZ

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235761 – 719NF-kappa-B inhibitor zetaAdd BLAST719

Proteomic databases

PaxDbiQ9BE45
PRIDEiQ9BE45

Expressioni

Inductioni

By LPS in polymorphonuclear cells, monocytes/macrophages and total lymphocytes, but not in T-lymphocytes (in vitro). By E.coli intramammary injection in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSBTAG00000010987
ExpressionAtlasiQ9BE45 baseline and differential

Interactioni

Subunit structurei

Interacts with NFKB1/p50. Interacts with RELA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014591

Structurei

3D structure databases

ProteinModelPortaliQ9BE45
SMRiQ9BE45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati444 – 473ANK 1Add BLAST30
Repeati480 – 509ANK 2Add BLAST30
Repeati513 – 542ANK 3Add BLAST30
Repeati552 – 581ANK 4Add BLAST30
Repeati583 – 608ANK 5Add BLAST26
Repeati613 – 642ANK 6Add BLAST30
Repeati649 – 682ANK 7Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni322 – 394Required for transcriptional activityBy similarityAdd BLAST73
Regioni405 – 719Interaction with NFKB1/p50By similarityAdd BLAST315

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 179Nuclear localization signalBy similarityAdd BLAST16

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000113023
HOVERGENiHBG059690
InParanoidiQ9BE45
KOiK14242
OMAiLHIRSHK
OrthoDBiEOG091G06D9
TreeFamiTF330224

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequencei

Sequence statusi: Complete.

Q9BE45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVDKLLDDS RGGEGLLDAA GDCGLMTSPL NLAYFYGASP PAAAPGACDG
60 70 80 90 100
GCSASGPSAP GSPGSDSSDF SSASSVSSCG AVESRPRGGA RAERLQVEPH
110 120 130 140 150
MGVVRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQSVNRE
160 170 180 190 200
QFTELKNTVS YSGKRKGSDS LSDGPACKRS ALLHTQFLTP PQTPTPAESM
210 220 230 240 250
EDVHHNESKQ DSCADLLQNI INIKNECSPV SLNTVQVSWM SPGEVPQGSP
260 270 280 290 300
HEQCQDLHRG QVFSPPQKYQ PFQVSSSPHM MDQASMYQYS PQNQSVQPPP
310 320 330 340 350
QHYTHNPALE YSPYSRTSQS PSYEPHLFGR EPQFCPDQSF APLLSDPRQS
360 370 380 390 400
ENIAVPPQTA PSVQQQIDTH LQNFSLMPPD TCEALARPDA SSTPLSTPLP
410 420 430 440 450
FPNLGGNPMS TTQLGKSFFQ WQVEQEENKL ANISQDQFLS KDADGDTFLH
460 470 480 490 500
IAVAQGRRAL SYVLARKMNA LHMLDIKEHN GQSAFQVAVA ANQHLIVQDL
510 520 530 540 550
VTLGAQVNTT DCWGRTPLHV CAEKGHSQVL QAIQKGAAGS NQFVDLEATN
560 570 580 590 600
YDGLTPLHCA VLAHNAVVHE LQRNQQPHSP EVQELLLKNK SLVDTIKCLI
610 620 630 640 650
QMGAAVEAKD RKSGRTALHL AAEEANLELI RLFLELPSCL SFVNAKAYNG
660 670 680 690 700
NTALHVAASL QYRVTQLDAV RLLMRKGADP STRNLENEQP VHLVPDGPVG
710
EQIRRILKGK SIQQRAPPY
Length:719
Mass (Da):78,239
Last modified:March 18, 2008 - v2
Checksum:iD8490551E5AC2816
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236Q → H in BAB39767 (PubMed:15010226).Curated1
Sequence conflicti244 – 248EVPQG → QSLRL in BAB39767 (PubMed:15010226).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058410 mRNA Translation: BAB39767.1
BC153257 mRNA Translation: AAI53258.1
RefSeqiNP_777151.1, NM_174726.1
UniGeneiBt.8227

Genome annotation databases

EnsembliENSBTAT00000014591; ENSBTAP00000014591; ENSBTAG00000010987
GeneIDi282713
KEGGibta:282713

Similar proteinsi

Entry informationi

Entry nameiIKBZ_BOVIN
AccessioniPrimary (citable) accession number: Q9BE45
Secondary accession number(s): A7Z059
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health