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Protein

NF-kappa-B inhibitor zeta

Gene

NFKBIZ

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor zeta
Alternative name(s):
I-kappa-B-zeta
Short name:
IkB-zeta
Short name:
IkappaBzeta
Molecule possessing ankyrin repeats induced by lipopolysaccharide
Short name:
MAIL
Gene namesi
Name:NFKBIZ
Synonyms:MAIL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719NF-kappa-B inhibitor zetaPRO_0000323576Add
BLAST

Proteomic databases

PaxDbiQ9BE45.
PRIDEiQ9BE45.

Expressioni

Inductioni

By LPS in polymorphonuclear cells, monocytes/macrophages and total lymphocytes, but not in T-lymphocytes (in vitro). By E.coli intramammary injection in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSBTAG00000010987.
ExpressionAtlasiQ9BE45. baseline and differential.

Interactioni

Subunit structurei

Interacts with NFKB1/p50. Interacts with RELA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014591.

Structurei

3D structure databases

ProteinModelPortaliQ9BE45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati444 – 47330ANK 1Add
BLAST
Repeati480 – 50930ANK 2Add
BLAST
Repeati513 – 54230ANK 3Add
BLAST
Repeati552 – 58130ANK 4Add
BLAST
Repeati583 – 60826ANK 5Add
BLAST
Repeati613 – 64230ANK 6Add
BLAST
Repeati649 – 68234ANK 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni322 – 39473Required for transcriptional activityBy similarityAdd
BLAST
Regioni405 – 719315Interaction with NFKB1/p50By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi164 – 17916Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000113023.
HOVERGENiHBG059690.
InParanoidiQ9BE45.
KOiK14242.
OMAiYEPNLFD.
OrthoDBiEOG091G06D9.
TreeFamiTF330224.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BE45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVDKLLDDS RGGEGLLDAA GDCGLMTSPL NLAYFYGASP PAAAPGACDG
60 70 80 90 100
GCSASGPSAP GSPGSDSSDF SSASSVSSCG AVESRPRGGA RAERLQVEPH
110 120 130 140 150
MGVVRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQSVNRE
160 170 180 190 200
QFTELKNTVS YSGKRKGSDS LSDGPACKRS ALLHTQFLTP PQTPTPAESM
210 220 230 240 250
EDVHHNESKQ DSCADLLQNI INIKNECSPV SLNTVQVSWM SPGEVPQGSP
260 270 280 290 300
HEQCQDLHRG QVFSPPQKYQ PFQVSSSPHM MDQASMYQYS PQNQSVQPPP
310 320 330 340 350
QHYTHNPALE YSPYSRTSQS PSYEPHLFGR EPQFCPDQSF APLLSDPRQS
360 370 380 390 400
ENIAVPPQTA PSVQQQIDTH LQNFSLMPPD TCEALARPDA SSTPLSTPLP
410 420 430 440 450
FPNLGGNPMS TTQLGKSFFQ WQVEQEENKL ANISQDQFLS KDADGDTFLH
460 470 480 490 500
IAVAQGRRAL SYVLARKMNA LHMLDIKEHN GQSAFQVAVA ANQHLIVQDL
510 520 530 540 550
VTLGAQVNTT DCWGRTPLHV CAEKGHSQVL QAIQKGAAGS NQFVDLEATN
560 570 580 590 600
YDGLTPLHCA VLAHNAVVHE LQRNQQPHSP EVQELLLKNK SLVDTIKCLI
610 620 630 640 650
QMGAAVEAKD RKSGRTALHL AAEEANLELI RLFLELPSCL SFVNAKAYNG
660 670 680 690 700
NTALHVAASL QYRVTQLDAV RLLMRKGADP STRNLENEQP VHLVPDGPVG
710
EQIRRILKGK SIQQRAPPY
Length:719
Mass (Da):78,239
Last modified:March 18, 2008 - v2
Checksum:iD8490551E5AC2816
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361Q → H in BAB39767 (PubMed:15010226).Curated
Sequence conflicti244 – 2485EVPQG → QSLRL in BAB39767 (PubMed:15010226).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058410 mRNA. Translation: BAB39767.1.
BC153257 mRNA. Translation: AAI53258.1.
RefSeqiNP_777151.1. NM_174726.1.
UniGeneiBt.8227.

Genome annotation databases

EnsembliENSBTAT00000014591; ENSBTAP00000014591; ENSBTAG00000010987.
GeneIDi282713.
KEGGibta:282713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058410 mRNA. Translation: BAB39767.1.
BC153257 mRNA. Translation: AAI53258.1.
RefSeqiNP_777151.1. NM_174726.1.
UniGeneiBt.8227.

3D structure databases

ProteinModelPortaliQ9BE45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014591.

Proteomic databases

PaxDbiQ9BE45.
PRIDEiQ9BE45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014591; ENSBTAP00000014591; ENSBTAG00000010987.
GeneIDi282713.
KEGGibta:282713.

Organism-specific databases

CTDi64332.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000113023.
HOVERGENiHBG059690.
InParanoidiQ9BE45.
KOiK14242.
OMAiYEPNLFD.
OrthoDBiEOG091G06D9.
TreeFamiTF330224.

Gene expression databases

BgeeiENSBTAG00000010987.
ExpressionAtlasiQ9BE45. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIKBZ_BOVIN
AccessioniPrimary (citable) accession number: Q9BE45
Secondary accession number(s): A7Z059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.