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Reviewed, UniProtKB/Swiss-Prot Q9BDT0 (GLCM_PANTR)

Last modified January 19, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glucosylceramidase
    EC=3.2.1.45
Alternative name(s):
    Beta-glucocerebrosidase
    Acid beta-glucosidase
    D-glucosyl-N-acylsphingosine glucohydrolase
Gene names
Name: GBA
Synonyms: GC
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

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Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

Subcellular location

Lysosome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 30 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 By similarity
Chain40 – 536497Glucosylceramidase
PRO_0000012179

Sites

Active site2741Proton donor By similarity
Active site3791Nucleophile By similarity

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation5011N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 55 By similarity
Disulfide bond57 ↔ 62 By similarity

Secondary structure

1 ................................................................................. 536
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q9BDT0-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E1A61BF380FF1888

FASTA53659,664
        10         20         30         40         50         60 
MEFSSPSREE CPKPSGRVSI MAGSLTGLLL LQAVSWASGA RPCIPKSFGY SSVVCVCNAT 

        70         80         90        100        110        120 
YCDSFDPPTF PALGTFSRYE STRSGRRMEL SMGTIQANHT GTGLLLTLQP EQKFQKVKGF 

       130        140        150        160        170        180 
GGAMTDAAAL NILALSPPAQ NLLLKSYFSE EGIGYNIIRV PMASCDFSIR TYTYADTPDD 

       190        200        210        220        230        240 
FQLHNFSLPE EDTKLKIPLI HRALQLAQRP VSLLASPWTS PTWLKTNGAV NGKGSLKGQP 

       250        260        270        280        290        300 
GDIYHQTWAR YFVKFLDAYA EHKLQFWAVT AENEPSAGLL SGYPFQCLGF TPEHQRDFIA 

       310        320        330        340        350        360 
RDLGPTLANS THHNVRLLML DDQRLLLPHW AKVVLTDPEA AKYVHGIAVH WYLDFLAPAK 

       370        380        390        400        410        420 
ATLGETHRLF PNTMLFASEA CVGSKFWEQS VRLGSWDRGM QYSHSIITNL LYHVVGWTDW 

       430        440        450        460        470        480 
NLALNPEGGP NWVRNFVDSP IIVDITKDTF YKQPMFYHLG HFSKFIPEGS QRVGLVASQK 

       490        500        510        520        530 
NDLDAVALMH PDGSAVVVVL NRSSKDVPLT IKDPAVGFLE TISPGYSIHT YLWRRQ

« Hide

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References

[1]"Allelic variability on the glucocerebrosidase pseudogene."
Martinez-Arias R., Comas D., Bertranpetit J.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF285236 Genomic DNA. Translation: AAK18162.1.
RefSeqNP_001008997.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VT0X-ray2.15A/B40-536[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BDT0.

Protein family/group databases

CAZyGH30. Glycoside Hydrolase Family 30.

Genome annotation databases

EnsemblENSPTRT00000002602; ENSPTRP00000002393; ENSPTRG00000001416; Pan troglodytes. [Genome view]
GeneID449571.
KEGGptr:449571.

Organism-specific databases

CTD449571.

Phylogenomic databases

eggNOGprNOG17120.
HOVERGENQ9BDT0.
InParanoidQ9BDT0.

Enzyme and pathway databases

BRENDA3.2.1.45. 264977.

Family and domain databases

InterProIPR001139. Glyco_hydro_30.
IPR017853. Glyco_hydro_catalytic_core.
IPR013781. Glyco_hydro_sg_catalytic.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHERPTHR11069. Glyco_hydro_30. 1 hit.
PfamPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSPR00843. GLHYDRLASE30.
ProtoNetSearch...

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Entry information

Entry nameGLCM_PANTR
AccessionPrimary (citable) accession number: Q9BDT0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2001
Last modified: January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents