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Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-BTA-114604 GPVI-mediated activation cascade
R-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-2454202 Fc epsilon receptor (FCERI) signaling
R-BTA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-BTA-2871796 FCERI mediated MAPK activation
R-BTA-2871809 FCERI mediated Ca+2 mobilization
R-BTA-2871837 FCERI mediated NF-kB activation
R-BTA-6798695 Neutrophil degranulation
R-BTA-75892 Platelet Adhesion to exposed collagen

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:FCER1G
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:28931 FCER1G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 23ExtracellularSequence analysis5
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 85CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001649919 – 85High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainBy similarity
Modified residuei64PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei75PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei77PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9BDR7
PRIDEiQ9BDR7

Expressioni

Gene expression databases

BgeeiENSBTAG00000024503

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages. Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD. Interacts with TARM1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033956

Structurei

3D structure databases

ProteinModelPortaliQ9BDR7
SMRiQ9BDR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 81ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ Eukaryota
ENOG410Z3W0 LUCA
GeneTreeiENSGT00390000003894
HOGENOMiHOG000293158
HOVERGENiHBG051601
InParanoidiQ9BDR7
KOiK07983
OMAiLYCRLKL
OrthoDBiEOG091G15OK
TreeFamiTF330937

Family and domain databases

InterProiView protein in InterPro
IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma
IPR003110 Phos_immunorcpt_sig_ITAM
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
PF11628 TCR_zetazeta, 1 hit
SMARTiView protein in SMART
SM00077 ITAM, 1 hit
PROSITEiView protein in PROSITE
PS51055 ITAM_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKLQV
60 70 80
RKAATASEKS DGIYTGLSTR TQETYETLKH EKPPQ
Length:85
Mass (Da):9,463
Last modified:June 1, 2001 - v1
Checksum:iA9569879FEF6BECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316499 mRNA Translation: AAK15275.1
BC102668 mRNA Translation: AAI02669.1
RefSeqiNP_776962.1, NM_174537.3
UniGeneiBt.8140

Genome annotation databases

EnsembliENSBTAT00000034054; ENSBTAP00000033956; ENSBTAG00000024503
GeneIDi282226
KEGGibta:282226

Similar proteinsi

Entry informationi

Entry nameiFCERG_BOVIN
AccessioniPrimary (citable) accession number: Q9BDR7
Secondary accession number(s): Q3SZX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health