Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High affinity immunoglobulin epsilon receptor subunit gamma

Gene

FCER1G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgE-binding protein

Enzyme and pathway databases

ReactomeiR-BTA-114604. GPVI-mediated activation cascade.
R-BTA-202733. Cell surface interactions at the vascular wall.
R-BTA-2454202. Fc epsilon receptor (FCERI) signaling.
R-BTA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-BTA-2871796. FCERI mediated MAPK activation.
R-BTA-2871809. FCERI mediated Ca+2 mobilization.
R-BTA-2871837. FCERI mediated NF-kB activation.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-75892. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin epsilon receptor subunit gamma
Alternative name(s):
Fc receptor gamma-chain
Short name:
FcRgamma
Fc-epsilon RI-gamma
IgE Fc receptor subunit gamma
Short name:
FceRI gamma
Gene namesi
Name:FCER1G
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 23ExtracellularSequence analysis5
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 85CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001649919 – 85High affinity immunoglobulin epsilon receptor subunit gammaAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainBy similarity
Modified residuei64PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei75PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei77PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9BDR7.
PRIDEiQ9BDR7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000024503.

Interactioni

Subunit structurei

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A (By similarity). Associated with CLEC6A (By similarity). Interacts with CLEC4E (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033956.

Structurei

3D structure databases

ProteinModelPortaliQ9BDR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 81ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the CD3Z/FCER1G family.Curated
Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiQ9BDR7.
KOiK07983.
OMAiLYCRLKL.
OrthoDBiEOG091G15OK.
TreeFamiTF330937.

Family and domain databases

InterProiIPR021663. CD3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKLQV
60 70 80
RKAATASEKS DGIYTGLSTR TQETYETLKH EKPPQ
Length:85
Mass (Da):9,463
Last modified:June 1, 2001 - v1
Checksum:iA9569879FEF6BECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316499 mRNA. Translation: AAK15275.1.
BC102668 mRNA. Translation: AAI02669.1.
RefSeqiNP_776962.1. NM_174537.3.
UniGeneiBt.8140.

Genome annotation databases

EnsembliENSBTAT00000034054; ENSBTAP00000033956; ENSBTAG00000024503.
GeneIDi282226.
KEGGibta:282226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316499 mRNA. Translation: AAK15275.1.
BC102668 mRNA. Translation: AAI02669.1.
RefSeqiNP_776962.1. NM_174537.3.
UniGeneiBt.8140.

3D structure databases

ProteinModelPortaliQ9BDR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033956.

Proteomic databases

PaxDbiQ9BDR7.
PRIDEiQ9BDR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000034054; ENSBTAP00000033956; ENSBTAG00000024503.
GeneIDi282226.
KEGGibta:282226.

Organism-specific databases

CTDi2207.

Phylogenomic databases

eggNOGiENOG410J5TQ. Eukaryota.
ENOG410Z3W0. LUCA.
GeneTreeiENSGT00390000003894.
HOGENOMiHOG000293158.
HOVERGENiHBG051601.
InParanoidiQ9BDR7.
KOiK07983.
OMAiLYCRLKL.
OrthoDBiEOG091G15OK.
TreeFamiTF330937.

Enzyme and pathway databases

ReactomeiR-BTA-114604. GPVI-mediated activation cascade.
R-BTA-202733. Cell surface interactions at the vascular wall.
R-BTA-2454202. Fc epsilon receptor (FCERI) signaling.
R-BTA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-BTA-2871796. FCERI mediated MAPK activation.
R-BTA-2871809. FCERI mediated Ca+2 mobilization.
R-BTA-2871837. FCERI mediated NF-kB activation.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-75892. Platelet Adhesion to exposed collagen.

Gene expression databases

BgeeiENSBTAG00000024503.

Family and domain databases

InterProiIPR021663. CD3_zeta/IgE_Fc_rcpt_gamma.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PfamiPF02189. ITAM. 1 hit.
PF11628. TCR_zetazeta. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCERG_BOVIN
AccessioniPrimary (citable) accession number: Q9BDR7
Secondary accession number(s): Q3SZX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.