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Q9BDQ5 (BKRB1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B1 bradykinin receptor

Short name=B1R
Short name=BK-1 receptor
Gene names
Name:BDKRB1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350B1 bradykinin receptor
PRO_0000069179

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 7210Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 11017Extracellular Potential
Transmembrane111 – 13121Helical; Name=3; Potential
Topological domain132 – 15019Cytoplasmic Potential
Transmembrane151 – 17121Helical; Name=4; Potential
Topological domain172 – 20433Extracellular Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 24823Cytoplasmic Potential
Transmembrane249 – 26921Helical; Name=6; Potential
Topological domain270 – 29223Extracellular Potential
Transmembrane293 – 31321Helical; Name=7; Potential
Topological domain314 – 35037Cytoplasmic Potential

Amino acid modifications

Lipidation3271S-palmitoyl cysteine Potential
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 186 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9BDQ5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 28272A819FF955E0

FASTA35039,509
        10         20         30         40         50         60 
MASRAPLELL PLNRSQLSPP NATTCDDAPE AWDLLHRVLP SVIIIICVCG LLGNLLVLAV 

        70         80         90        100        110        120 
LLRPRRRLNV AEMYLANLAA SDLVFVLGLP FWAANISNQF RWPFGGLLCR LVNGVIKANL 

       130        140        150        160        170        180 
FISIFLVVAI SRDRYRALVH PMATRRRRQA RATCVLIWVA GSLLSVPTFL FRSIEAVPEL 

       190        200        210        220        230        240 
NNDSACVLLH PPGAWHVARM VELNVLGFLL PLAAIVFFNC HILASLRGRP EVRGARCGGP 

       250        260        270        280        290        300 
PDGRTTALIL TFVAAFLVCW TPYHFFAFLE FLTQVQVVRG CFWENFKDLG LQYASFFAFI 

       310        320        330        340        350 
NSCLNPVIYV FVGRLFRTRV WDLFKQCAPR RPPAVSWSHR KRVLQLFWQN 

« Hide

References

[1]"Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors."
Hess F., Hey P.J., Chen T.-B., O'Brien J., Omalley S.S., Pettibone D.J., Chang R.S.L.
Biol. Chem. 382:123-129(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF334947 Genomic DNA. Translation: AAK21216.1.
RefSeqNP_001014306.1. NM_001014284.1.
UniGeneCfa.23470.

3D structure databases

ProteinModelPortalQ9BDQ5.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9BDQ5.
ChEMBLCHEMBL4724.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID490847.
KEGGcfa:490847.

Organism-specific databases

CTD623.

Phylogenomic databases

HOVERGENHBG103183.
KOK03915.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20863787.

Entry information

Entry nameBKRB1_CANFA
AccessionPrimary (citable) accession number: Q9BDQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries