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Q9BDQ5

- BKRB1_CANFA

UniProt

Q9BDQ5 - BKRB1_CANFA

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Protein

B1 bradykinin receptor

Gene
BDKRB1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  1. bradykinin receptor activity Source: InterPro

GO - Biological processi

  1. inflammatory response Source: InterPro
  2. response to mechanical stimulus Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Extracellular Reviewed predictionAdd
BLAST
Transmembranei42 – 6221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini63 – 7210Cytoplasmic Reviewed prediction
Transmembranei73 – 9321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini94 – 11017Extracellular Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini132 – 15019Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini172 – 20433Extracellular Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini226 – 24823Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei249 – 26921Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini270 – 29223Extracellular Reviewed predictionAdd
BLAST
Transmembranei293 – 31321Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini314 – 35037Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350B1 bradykinin receptorPRO_0000069179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi109 ↔ 186 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Lipidationi327 – 3271S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9BDQ5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG103183.
KOiK03915.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BDQ5-1 [UniParc]FASTAAdd to Basket

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MASRAPLELL PLNRSQLSPP NATTCDDAPE AWDLLHRVLP SVIIIICVCG    50
LLGNLLVLAV LLRPRRRLNV AEMYLANLAA SDLVFVLGLP FWAANISNQF 100
RWPFGGLLCR LVNGVIKANL FISIFLVVAI SRDRYRALVH PMATRRRRQA 150
RATCVLIWVA GSLLSVPTFL FRSIEAVPEL NNDSACVLLH PPGAWHVARM 200
VELNVLGFLL PLAAIVFFNC HILASLRGRP EVRGARCGGP PDGRTTALIL 250
TFVAAFLVCW TPYHFFAFLE FLTQVQVVRG CFWENFKDLG LQYASFFAFI 300
NSCLNPVIYV FVGRLFRTRV WDLFKQCAPR RPPAVSWSHR KRVLQLFWQN 350
Length:350
Mass (Da):39,509
Last modified:June 1, 2001 - v1
Checksum:i28272A819FF955E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF334947 Genomic DNA. Translation: AAK21216.1.
RefSeqiNP_001014306.1. NM_001014284.1.
UniGeneiCfa.23470.

Genome annotation databases

GeneIDi490847.
KEGGicfa:490847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF334947 Genomic DNA. Translation: AAK21216.1 .
RefSeqi NP_001014306.1. NM_001014284.1.
UniGenei Cfa.23470.

3D structure databases

ProteinModelPortali Q9BDQ5.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9BDQ5.
ChEMBLi CHEMBL4724.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 490847.
KEGGi cfa:490847.

Organism-specific databases

CTDi 623.

Phylogenomic databases

HOVERGENi HBG103183.
KOi K03915.

Miscellaneous databases

NextBioi 20863787.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors."
    Hess F., Hey P.J., Chen T.-B., O'Brien J., Omalley S.S., Pettibone D.J., Chang R.S.L.
    Biol. Chem. 382:123-129(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBKRB1_CANFA
AccessioniPrimary (citable) accession number: Q9BDQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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