Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BDQ5

- BKRB1_CANFA

UniProt

Q9BDQ5 - BKRB1_CANFA

Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

    GO - Molecular functioni

    1. bradykinin receptor activity Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: InterPro
    2. response to mechanical stimulus Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B1 bradykinin receptor
    Short name:
    B1R
    Short name:
    BK-1 receptor
    Gene namesi
    Name:BDKRB1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350B1 bradykinin receptorPRO_0000069179Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 186PROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Lipidationi327 – 3271S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BDQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7210CytoplasmicSequence Analysis
    Topological domaini94 – 11017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 20433ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24823CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 29223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 35037CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG103183.
    KOiK03915.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001186. Brdyknn_1_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00425. BRADYKININR.
    PR00993. BRADYKINNB1R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BDQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRAPLELL PLNRSQLSPP NATTCDDAPE AWDLLHRVLP SVIIIICVCG    50
    LLGNLLVLAV LLRPRRRLNV AEMYLANLAA SDLVFVLGLP FWAANISNQF 100
    RWPFGGLLCR LVNGVIKANL FISIFLVVAI SRDRYRALVH PMATRRRRQA 150
    RATCVLIWVA GSLLSVPTFL FRSIEAVPEL NNDSACVLLH PPGAWHVARM 200
    VELNVLGFLL PLAAIVFFNC HILASLRGRP EVRGARCGGP PDGRTTALIL 250
    TFVAAFLVCW TPYHFFAFLE FLTQVQVVRG CFWENFKDLG LQYASFFAFI 300
    NSCLNPVIYV FVGRLFRTRV WDLFKQCAPR RPPAVSWSHR KRVLQLFWQN 350
    Length:350
    Mass (Da):39,509
    Last modified:June 1, 2001 - v1
    Checksum:i28272A819FF955E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF334947 Genomic DNA. Translation: AAK21216.1.
    RefSeqiNP_001014306.1. NM_001014284.1.
    UniGeneiCfa.23470.

    Genome annotation databases

    GeneIDi490847.
    KEGGicfa:490847.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF334947 Genomic DNA. Translation: AAK21216.1 .
    RefSeqi NP_001014306.1. NM_001014284.1.
    UniGenei Cfa.23470.

    3D structure databases

    ProteinModelPortali Q9BDQ5.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9BDQ5.
    ChEMBLi CHEMBL4724.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 490847.
    KEGGi cfa:490847.

    Organism-specific databases

    CTDi 623.

    Phylogenomic databases

    HOVERGENi HBG103183.
    KOi K03915.

    Miscellaneous databases

    NextBioi 20863787.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001186. Brdyknn_1_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00425. BRADYKININR.
    PR00993. BRADYKINNB1R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors."
      Hess F., Hey P.J., Chen T.-B., O'Brien J., Omalley S.S., Pettibone D.J., Chang R.S.L.
      Biol. Chem. 382:123-129(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiBKRB1_CANFA
    AccessioniPrimary (citable) accession number: Q9BDQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3