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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 110ExtracellularSequence analysisAdd BLAST17
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini132 – 150CytoplasmicSequence analysisAdd BLAST19
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 204ExtracellularSequence analysisAdd BLAST33
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 248CytoplasmicSequence analysisAdd BLAST23
Transmembranei249 – 269Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini270 – 292ExtracellularSequence analysisAdd BLAST23
Transmembranei293 – 313Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini314 – 350CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691791 – 350B1 bradykinin receptorAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 186PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Lipidationi327S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9BDQ5.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000039552.

Chemistry databases

BindingDBiQ9BDQ5.

Structurei

3D structure databases

ProteinModelPortaliQ9BDQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG103183.
InParanoidiQ9BDQ5.
KOiK03915.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BDQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRAPLELL PLNRSQLSPP NATTCDDAPE AWDLLHRVLP SVIIIICVCG
60 70 80 90 100
LLGNLLVLAV LLRPRRRLNV AEMYLANLAA SDLVFVLGLP FWAANISNQF
110 120 130 140 150
RWPFGGLLCR LVNGVIKANL FISIFLVVAI SRDRYRALVH PMATRRRRQA
160 170 180 190 200
RATCVLIWVA GSLLSVPTFL FRSIEAVPEL NNDSACVLLH PPGAWHVARM
210 220 230 240 250
VELNVLGFLL PLAAIVFFNC HILASLRGRP EVRGARCGGP PDGRTTALIL
260 270 280 290 300
TFVAAFLVCW TPYHFFAFLE FLTQVQVVRG CFWENFKDLG LQYASFFAFI
310 320 330 340 350
NSCLNPVIYV FVGRLFRTRV WDLFKQCAPR RPPAVSWSHR KRVLQLFWQN
Length:350
Mass (Da):39,509
Last modified:June 1, 2001 - v1
Checksum:i28272A819FF955E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334947 Genomic DNA. Translation: AAK21216.1.
RefSeqiNP_001014306.1. NM_001014284.1.
UniGeneiCfa.23470.

Genome annotation databases

GeneIDi490847.
KEGGicfa:490847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334947 Genomic DNA. Translation: AAK21216.1.
RefSeqiNP_001014306.1. NM_001014284.1.
UniGeneiCfa.23470.

3D structure databases

ProteinModelPortaliQ9BDQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000039552.

Chemistry databases

BindingDBiQ9BDQ5.
ChEMBLiCHEMBL4724.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9BDQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi490847.
KEGGicfa:490847.

Organism-specific databases

CTDi623.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG103183.
InParanoidiQ9BDQ5.
KOiK03915.

Miscellaneous databases

PROiQ9BDQ5.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB1_CANLF
AccessioniPrimary (citable) accession number: Q9BDQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.