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Protein

B1 bradykinin receptor

Gene

BDKRB1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  1. bradykinin receptor activity Source: InterPro

GO - Biological processi

  1. inflammatory response Source: InterPro
  2. response to mechanical stimulus Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Gene namesi
Name:BDKRB1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 7210CytoplasmicSequence Analysis
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 15019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 20433ExtracellularSequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 24823CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei249 – 26921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini270 – 29223ExtracellularSequence AnalysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini314 – 35037CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350B1 bradykinin receptorPRO_0000069179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 186PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Lipidationi327 – 3271S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9BDQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG103183.
InParanoidiQ9BDQ5.
KOiK03915.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BDQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRAPLELL PLNRSQLSPP NATTCDDAPE AWDLLHRVLP SVIIIICVCG
60 70 80 90 100
LLGNLLVLAV LLRPRRRLNV AEMYLANLAA SDLVFVLGLP FWAANISNQF
110 120 130 140 150
RWPFGGLLCR LVNGVIKANL FISIFLVVAI SRDRYRALVH PMATRRRRQA
160 170 180 190 200
RATCVLIWVA GSLLSVPTFL FRSIEAVPEL NNDSACVLLH PPGAWHVARM
210 220 230 240 250
VELNVLGFLL PLAAIVFFNC HILASLRGRP EVRGARCGGP PDGRTTALIL
260 270 280 290 300
TFVAAFLVCW TPYHFFAFLE FLTQVQVVRG CFWENFKDLG LQYASFFAFI
310 320 330 340 350
NSCLNPVIYV FVGRLFRTRV WDLFKQCAPR RPPAVSWSHR KRVLQLFWQN
Length:350
Mass (Da):39,509
Last modified:June 1, 2001 - v1
Checksum:i28272A819FF955E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334947 Genomic DNA. Translation: AAK21216.1.
RefSeqiNP_001014306.1. NM_001014284.1.
UniGeneiCfa.23470.

Genome annotation databases

GeneIDi490847.
KEGGicfa:490847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334947 Genomic DNA. Translation: AAK21216.1.
RefSeqiNP_001014306.1. NM_001014284.1.
UniGeneiCfa.23470.

3D structure databases

ProteinModelPortaliQ9BDQ5.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9BDQ5.
ChEMBLiCHEMBL4724.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi490847.
KEGGicfa:490847.

Organism-specific databases

CTDi623.

Phylogenomic databases

HOVERGENiHBG103183.
InParanoidiQ9BDQ5.
KOiK03915.

Miscellaneous databases

NextBioi20863787.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and pharmacological characterization of the canine B1 and B2 bradykinin receptors."
    Hess F., Hey P.J., Chen T.-B., O'Brien J., Omalley S.S., Pettibone D.J., Chang R.S.L.
    Biol. Chem. 382:123-129(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBKRB1_CANFA
AccessioniPrimary (citable) accession number: Q9BDQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.