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Q9BDP9 (CART_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cocaine- and amphetamine-regulated transcript protein

Cleaved into the following 2 chains:

  1. CART(55-102)
  2. CART(62-102)
Gene names
Name:CARTPT
Synonyms:CART
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length66 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the CART family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionNeuropeptide
Neurotransmitter
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from sequence or structural similarity. Source: HGNC

activation of MAPKK activity

Inferred from sequence or structural similarity. Source: HGNC

adult feeding behavior

Inferred from sequence or structural similarity. Source: HGNC

cellular glucose homeostasis

Inferred from sequence or structural similarity. Source: HGNC

cellular response to starvation

Inferred from sequence or structural similarity. Source: HGNC

circadian regulation of gene expression

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of appetite

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of bone resorption

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of blood pressure

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of epinephrine secretion

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of transmission of nerve impulse

Inferred from sequence or structural similarity. Source: HGNC

synaptic transmission

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from sequence or structural similarity. Source: HGNC

secretory granule

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›66›66Cocaine- and amphetamine-regulated transcript protein
PRO_0000045382
Peptide21 – ›66›46CART(55-102) By similarity
PRO_0000004440
Peptide28 – ›66›39CART(62-102) By similarity
PRO_0000004441

Amino acid modifications

Disulfide bond34 ↔ 52 By similarity
Disulfide bond40 ↔ 60 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue661

Sequences

Sequence LengthMass (Da)Tools
Q9BDP9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D217D4B6E94155F1

FASTA667,451
        10         20         30         40         50         60 
HEKELIEALQ EVLKKLKSKR IPIYEKKYGQ VPMCDAGEQC AVRKGARIGK LCDCPRGTSC 


NSFLLK 

« Hide

References

[1]"Sus scrofa cocaine- and amphetamine-regulated transcript (CART) cDNA."
Matteri R.L.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF338229 mRNA. Translation: AAK26325.1.
UniGeneSsc.15900.

3D structure databases

ProteinModelPortalQ9BDP9.
SMRQ9BDP9. Positions 28-66.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG47455.

Family and domain databases

Gene3D4.10.40.30. 1 hit.
InterProIPR009106. CART.
[Graphical view]
PANTHERPTHR16655. PTHR16655. 1 hit.
PfamPF06373. CART. 1 hit.
[Graphical view]
SUPFAMSSF64546. SSF64546. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCART_PIG
AccessionPrimary (citable) accession number: Q9BDP9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families