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Q9BDP9

- CART_PIG

UniProt

Q9BDP9 - CART_PIG

Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

CARTPT

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

    GO - Biological processi

    1. activation of MAPKK activity Source: HGNC
    2. adult feeding behavior Source: HGNC
    3. cellular glucose homeostasis Source: HGNC
    4. cellular response to starvation Source: HGNC
    5. circadian regulation of gene expression Source: HGNC
    6. G-protein coupled receptor signaling pathway Source: HGNC
    7. negative regulation of appetite Source: HGNC
    8. negative regulation of bone resorption Source: Ensembl
    9. neuropeptide signaling pathway Source: UniProtKB-KW
    10. positive regulation of blood pressure Source: HGNC
    11. positive regulation of epinephrine secretion Source: HGNC
    12. positive regulation of transmission of nerve impulse Source: HGNC
    13. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cocaine- and amphetamine-regulated transcript protein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CARTPT
    Synonyms:CART
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: HGNC
    2. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›66›66Cocaine- and amphetamine-regulated transcript proteinPRO_0000045382Add
    BLAST
    Peptidei21 – ›66›46CART(55-102)By similarityPRO_0000004440Add
    BLAST
    Peptidei28 – ›66›39CART(62-102)By similarityPRO_0000004441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 52By similarity
    Disulfide bondi40 ↔ 60By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BDP9.
    SMRiQ9BDP9. Positions 28-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CART family.Curated

    Phylogenomic databases

    eggNOGiNOG47455.

    Family and domain databases

    Gene3Di4.10.40.30. 1 hit.
    InterProiIPR009106. CART.
    [Graphical view]
    PANTHERiPTHR16655. PTHR16655. 1 hit.
    PfamiPF06373. CART. 1 hit.
    [Graphical view]
    SUPFAMiSSF64546. SSF64546. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BDP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    HEKELIEALQ EVLKKLKSKR IPIYEKKYGQ VPMCDAGEQC AVRKGARIGK   50
    LCDCPRGTSC NSFLLK 66
    Length:66
    Mass (Da):7,451
    Last modified:June 1, 2001 - v1
    Checksum:iD217D4B6E94155F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei66 – 661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338229 mRNA. Translation: AAK26325.1.
    UniGeneiSsc.15900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338229 mRNA. Translation: AAK26325.1 .
    UniGenei Ssc.15900.

    3D structure databases

    ProteinModelPortali Q9BDP9.
    SMRi Q9BDP9. Positions 28-66.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG47455.

    Family and domain databases

    Gene3Di 4.10.40.30. 1 hit.
    InterProi IPR009106. CART.
    [Graphical view ]
    PANTHERi PTHR16655. PTHR16655. 1 hit.
    Pfami PF06373. CART. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64546. SSF64546. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sus scrofa cocaine- and amphetamine-regulated transcript (CART) cDNA."
      Matteri R.L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiCART_PIG
    AccessioniPrimary (citable) accession number: Q9BDP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3