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Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

CARTPT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 2 chains:
Gene namesi
Name:CARTPT
Synonyms:CART
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›66›66Cocaine- and amphetamine-regulated transcript proteinPRO_0000045382Add
BLAST
Peptidei21 – ›66›46CART(55-102)By similarityPRO_0000004440Add
BLAST
Peptidei28 – ›66›39CART(62-102)By similarityPRO_0000004441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 52By similarity
Disulfide bondi40 ↔ 60By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9BDP9.
PeptideAtlasiQ9BDP9.

Expressioni

Gene expression databases

GenevisibleiQ9BDP9. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017982.

Structurei

3D structure databases

ProteinModelPortaliQ9BDP9.
SMRiQ9BDP9. Positions 28-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.Curated

Phylogenomic databases

eggNOGiENOG410J0KJ. Eukaryota.
ENOG410YRI1. LUCA.
InParanoidiQ9BDP9.
OrthoDBiEOG091G0Y1C.

Family and domain databases

Gene3Di4.10.40.30. 1 hit.
InterProiIPR009106. CART.
[Graphical view]
PANTHERiPTHR16655. PTHR16655. 1 hit.
PfamiPF06373. CART. 1 hit.
[Graphical view]
SUPFAMiSSF64546. SSF64546. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HEKELIEALQ EVLKKLKSKR IPIYEKKYGQ VPMCDAGEQC AVRKGARIGK
60
LCDCPRGTSC NSFLLK
Length:66
Mass (Da):7,451
Last modified:June 1, 2001 - v1
Checksum:iD217D4B6E94155F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338229 mRNA. Translation: AAK26325.1.
UniGeneiSsc.15900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338229 mRNA. Translation: AAK26325.1.
UniGeneiSsc.15900.

3D structure databases

ProteinModelPortaliQ9BDP9.
SMRiQ9BDP9. Positions 28-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017982.

Proteomic databases

PaxDbiQ9BDP9.
PeptideAtlasiQ9BDP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J0KJ. Eukaryota.
ENOG410YRI1. LUCA.
InParanoidiQ9BDP9.
OrthoDBiEOG091G0Y1C.

Gene expression databases

GenevisibleiQ9BDP9. SS.

Family and domain databases

Gene3Di4.10.40.30. 1 hit.
InterProiIPR009106. CART.
[Graphical view]
PANTHERiPTHR16655. PTHR16655. 1 hit.
PfamiPF06373. CART. 1 hit.
[Graphical view]
SUPFAMiSSF64546. SSF64546. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCART_PIG
AccessioniPrimary (citable) accession number: Q9BDP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.