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Q9BDP9

- CART_PIG

UniProt

Q9BDP9 - CART_PIG

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Protein
Cocaine- and amphetamine-regulated transcript protein
Gene
CARTPT, CART
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus By similarity.

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: HGNC
  2. activation of MAPKK activity Source: HGNC
  3. adult feeding behavior Source: HGNC
  4. cellular glucose homeostasis Source: HGNC
  5. cellular response to starvation Source: HGNC
  6. circadian regulation of gene expression Source: HGNC
  7. negative regulation of appetite Source: HGNC
  8. negative regulation of bone resorption Source: Ensembl
  9. neuropeptide signaling pathway Source: UniProtKB-KW
  10. positive regulation of blood pressure Source: HGNC
  11. positive regulation of epinephrine secretion Source: HGNC
  12. positive regulation of transmission of nerve impulse Source: HGNC
  13. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 2 chains:
Gene namesi
Name:CARTPT
Synonyms:CART
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular space Source: HGNC
  2. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›66›66Cocaine- and amphetamine-regulated transcript protein
PRO_0000045382Add
BLAST
Peptidei21 – ›66›46CART(55-102) By similarity
PRO_0000004440Add
BLAST
Peptidei28 – ›66›39CART(62-102) By similarity
PRO_0000004441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 52 By similarity
Disulfide bondi40 ↔ 60 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ9BDP9.
SMRiQ9BDP9. Positions 28-66.

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.

Phylogenomic databases

eggNOGiNOG47455.

Family and domain databases

Gene3Di4.10.40.30. 1 hit.
InterProiIPR009106. CART.
[Graphical view]
PANTHERiPTHR16655. PTHR16655. 1 hit.
PfamiPF06373. CART. 1 hit.
[Graphical view]
SUPFAMiSSF64546. SSF64546. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDP9-1 [UniParc]FASTAAdd to Basket

« Hide

HEKELIEALQ EVLKKLKSKR IPIYEKKYGQ VPMCDAGEQC AVRKGARIGK   50
LCDCPRGTSC NSFLLK 66
Length:66
Mass (Da):7,451
Last modified:June 1, 2001 - v1
Checksum:iD217D4B6E94155F1
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei66 – 661

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF338229 mRNA. Translation: AAK26325.1.
UniGeneiSsc.15900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF338229 mRNA. Translation: AAK26325.1 .
UniGenei Ssc.15900.

3D structure databases

ProteinModelPortali Q9BDP9.
SMRi Q9BDP9. Positions 28-66.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG47455.

Family and domain databases

Gene3Di 4.10.40.30. 1 hit.
InterProi IPR009106. CART.
[Graphical view ]
PANTHERi PTHR16655. PTHR16655. 1 hit.
Pfami PF06373. CART. 1 hit.
[Graphical view ]
SUPFAMi SSF64546. SSF64546. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sus scrofa cocaine- and amphetamine-regulated transcript (CART) cDNA."
    Matteri R.L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiCART_PIG
AccessioniPrimary (citable) accession number: Q9BDP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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