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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Receptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 173ExtracellularSequence analysisAdd BLAST148
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 333CytoplasmicSequence analysisAdd BLAST139

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003456526 – 333Tumor necrosis factor receptor superfamily member 6Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 73PROSITE-ProRule annotation
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 101PROSITE-ProRule annotation
Disulfide bondi104 ↔ 119PROSITE-ProRule annotation
Disulfide bondi107 ↔ 127PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 157PROSITE-ProRule annotation
Disulfide bondi149 ↔ 165PROSITE-ProRule annotation
Modified residuei213PhosphothreonineBy similarity1
Modified residuei223PhosphoserineBy similarity1
Modified residuei320PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9BDP2

Interactioni

Subunit structurei

Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000014651

Structurei

3D structure databases

ProteinModelPortaliQ9BDP2
SMRiQ9BDP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 83TNFR-Cys 1Add BLAST37
Repeati84 – 127TNFR-Cys 2Add BLAST44
Repeati128 – 166TNFR-Cys 3Add BLAST39
Domaini228 – 312DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 315Interaction with HIPK3By similarityAdd BLAST105
Regioni228 – 252Interaction with CALMBy similarityAdd BLAST25

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23A Eukaryota
ENOG4112ADB LUCA
HOVERGENiHBG004091
InParanoidiQ9BDP2
KOiK04390

Family and domain databases

CDDicd08316 Death_FAS_TNFRSF6, 1 hit
cd10579 TNFRSF6, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR008063 Fas_rcpt
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR033998 TNFRSF6_death
IPR033999 TNFRSF6_N
PANTHERiPTHR23097:SF114 PTHR23097:SF114, 2 hits
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01680 TNFACTORR6
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVVRLLS KCVNAQVTDI SSKGFELRKI VTTIETQNLE
60 70 80 90 100
GLHHEGQFCR NPCPPGERKA RDCTVNEDEP DCVPCQEGEE YTDKGHFSSK
110 120 130 140 150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSAVC EHCDPCTKCK
160 170 180 190 200
HGIIEECTLT SNTKCKEEDS RSDLLWLCLL LLLLLIPPIV YVVIKEPCRK
210 220 230 240 250
RRKENQGPHE STTLNPETAI NLSDVDLSKY ITTIAGAMTL SQVKDFVRKN
260 270 280 290 300
GVSEAKIDEI KNDNVQDTAE QKVQLLRNWY QLHGKKDACD TLIKGLKTAD
310 320 330
LCTLAEKIHA VILKDITSDT ENSNFGNEVQ NLV
Length:333
Mass (Da):37,468
Last modified:June 1, 2001 - v1
Checksum:i98C17F766762F287
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti75V → A1 Publication1
Natural varianti89E → K1 Publication1
Natural varianti196E → K1 Publication1
Natural varianti201R → H1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344833 mRNA Translation: AAK37529.1
RefSeqiNP_001028105.1, NM_001032933.2
UniGeneiMmu.649

Genome annotation databases

GeneIDi574332
KEGGimcc:574332

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTNR6_MACMU
AccessioniPrimary (citable) accession number: Q9BDP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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