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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Receptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismiMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 171ExtracellularSequence analysisAdd BLAST146
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 331CytoplasmicSequence analysisAdd BLAST139

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003456626 – 331Tumor necrosis factor receptor superfamily member 6Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 73PROSITE-ProRule annotation
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 101PROSITE-ProRule annotation
Disulfide bondi104 ↔ 119PROSITE-ProRule annotation
Disulfide bondi107 ↔ 127PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 157PROSITE-ProRule annotation
Disulfide bondi149 ↔ 165PROSITE-ProRule annotation
Modified residuei211PhosphothreonineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei318PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9BDN0
SMRiQ9BDN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 83TNFR-Cys 1Add BLAST37
Repeati84 – 127TNFR-Cys 2Add BLAST44
Repeati128 – 166TNFR-Cys 3Add BLAST39
Domaini226 – 310DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 313Interaction with HIPK3By similarityAdd BLAST105
Regioni226 – 250Interaction with CALMBy similarityAdd BLAST25

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004091
OrthoDBiEOG091G0DU6

Family and domain databases

CDDicd08316 Death_FAS_TNFRSF6, 1 hit
cd10579 TNFRSF6, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR008063 Fas_rcpt
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR033998 TNFRSF6_death
IPR033999 TNFRSF6_N
PANTHERiPTHR23097:SF114 PTHR23097:SF114, 2 hits
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01680 TNFACTORR6
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTYVVRLLS KCVNAQVTDI SSKGFELRKI VTTIETQNLE
60 70 80 90 100
GLHHEGQFCR NPCPPGERKA RDCTVNEDEP DCVPCQEGKE YTDKGHFSSK
110 120 130 140 150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSAVC EHCDPCTKCK
160 170 180 190 200
HGIIEECTLT SNTKCKEEDS RSDLPWLCLL LLLIPPIVYV VIKKACRKHR
210 220 230 240 250
KENQGPHEST TLNPETAINL SDVDLSKYIT TIAGAMTLSQ VKDFVRKNGV
260 270 280 290 300
SEAKIDEIKN DNVQDTAEQK VQLLRNWYQL HGKKDACDTL IKGLKTADLC
310 320 330
TLAEKIHAVI LKDITSDTEN SNFGNEVQNL V
Length:331
Mass (Da):37,255
Last modified:June 1, 2001 - v1
Checksum:iA6CFE3DA12C94765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344850 mRNA Translation: AAK37610.1
RefSeqiNP_001292816.1, NM_001305887.1

Genome annotation databases

GeneIDi105480710

Similar proteinsi

Entry informationi

Entry nameiTNR6_MACNE
AccessioniPrimary (citable) accession number: Q9BDN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health