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Protein

Allograft inflammatory factor 1

Gene

AIF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in macrophage activation and function.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi58 – 69121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1
Short name:
AIF-1
Gene namesi
Name:AIF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectionruffle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cell projectionphagocytic cup By similarity

  • Note: Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 147146Allograft inflammatory factor 1PRO_0000244410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei11 – 111N6-acetyllysineBy similarity
Modified residuei39 – 391PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9BDK2.
PRIDEiQ9BDK2.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027388.

Structurei

3D structure databases

ProteinModelPortaliQ9BDK2.
SMRiQ9BDK2. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 8036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11535EF-hand 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCUI. Eukaryota.
ENOG411206J. LUCA.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ9BDK2.
KOiK18617.
OMAiAFKKKYM.
OrthoDBiEOG73FQPC.
TreeFamiTF320736.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETRDLQGG KAFGLRKAQQ EERINEINQQ FLDDPKYSSD EDLPSKLEAF
60 70 80 90 100
KKKYMEFDLN EDGGIDIMSL KRMMEKLGVP KTHLELKKLI MEVSSGPGET
110 120 130 140
FSYSDFLKMM LGKRSAILKM ILMYEEKARE QEKPTGLPAK KAISELP
Length:147
Mass (Da):16,855
Last modified:June 1, 2001 - v1
Checksum:i60638F76A18E1BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348450 mRNA. Translation: AAK30155.1.
BC102890 mRNA. Translation: AAI02891.1.
RefSeqiNP_776410.1. NM_173985.2.
UniGeneiBt.49700.

Genome annotation databases

EnsembliENSBTAT00000027388; ENSBTAP00000027388; ENSBTAG00000020554.
GeneIDi280989.
KEGGibta:280989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348450 mRNA. Translation: AAK30155.1.
BC102890 mRNA. Translation: AAI02891.1.
RefSeqiNP_776410.1. NM_173985.2.
UniGeneiBt.49700.

3D structure databases

ProteinModelPortaliQ9BDK2.
SMRiQ9BDK2. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027388.

Proteomic databases

PaxDbiQ9BDK2.
PRIDEiQ9BDK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027388; ENSBTAP00000027388; ENSBTAG00000020554.
GeneIDi280989.
KEGGibta:280989.

Organism-specific databases

CTDi199.

Phylogenomic databases

eggNOGiENOG410KCUI. Eukaryota.
ENOG411206J. LUCA.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ9BDK2.
KOiK18617.
OMAiAFKKKYM.
OrthoDBiEOG73FQPC.
TreeFamiTF320736.

Miscellaneous databases

NextBioi20805090.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Increased messenger RNA for allograft inflammatory factor-1, LERK-5, and a novel gene in 17.5-day relative to 15.5-day bovine embryos."
    Glover M.D., Seidel G.E. Jr.
    Biol. Reprod. 69:1002-1012(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiAIF1_BOVIN
AccessioniPrimary (citable) accession number: Q9BDK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.