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Q9BDJ6

- GHRL_BOVIN

UniProt

Q9BDJ6 - GHRL_BOVIN

Protein

Appetite-regulating hormone

Gene

GHRL

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation By similarity.By similarity
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility By similarity.By similarity

    GO - Molecular functioni

    1. ghrelin receptor binding Source: UniProtKB
    2. growth hormone-releasing hormone activity Source: UniProtKB
    3. hormone activity Source: UniProtKB
    4. protein tyrosine kinase activator activity Source: UniProtKB

    GO - Biological processi

    1. actin polymerization or depolymerization Source: UniProtKB
    2. activation of MAPK activity Source: UniProtKB
    3. decidualization Source: UniProtKB
    4. dendrite development Source: UniProtKB
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of endothelial cell proliferation Source: UniProtKB
    7. negative regulation of inflammatory response Source: UniProtKB
    8. negative regulation of insulin secretion Source: UniProtKB
    9. negative regulation of interleukin-1 beta production Source: UniProtKB
    10. negative regulation of interleukin-6 biosynthetic process Source: UniProtKB
    11. negative regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
    12. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    13. positive regulation of insulin secretion Source: UniProtKB
    14. positive regulation of protein tyrosine kinase activity Source: GOC
    15. positive regulation of response to food Source: UniProtKB
    16. positive regulation of synapse assembly Source: UniProtKB
    17. regulation of cell proliferation Source: UniProtKB
    18. regulation of response to food Source: UniProtKB
    19. response to estrogen Source: UniProtKB
    20. response to hormone Source: UniProtKB

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_209521. G alpha (q) signalling events.
    REACT_219025. Peptide ligand-binding receptors.
    REACT_223503. Synthesis, secretion, and deacylation of Ghrelin.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Appetite-regulating hormone
    Alternative name(s):
    Growth hormone secretagogue
    Growth hormone-releasing peptide
    Motilin-related peptide
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GHRL
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 22

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Peptidei24 – 5027GhrelinBy similarityPRO_0000019194Add
    BLAST
    Propeptidei51 – 7424Removed in mature formBy similarityPRO_0000019195Add
    BLAST
    Peptidei75 – 9723ObestatinBy similarityPRO_0000045132Add
    BLAST
    Propeptidei98 – 11619Removed in mature formBy similarityPRO_0000045133Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi26 – 261O-octanoyl serineBy similarity
    Modified residuei97 – 971Leucine amideBy similarity

    Post-translational modificationi

    O-octanoylation is essential for ghrelin activity.By similarity
    Amidation of Leu-97 is essential for obestatin activity.By similarity

    Keywords - PTMi

    Amidation, Lipoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the motilin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45924.
    GeneTreeiENSGT00390000004064.
    HOGENOMiHOG000236303.
    HOVERGENiHBG018522.
    KOiK05254.

    Family and domain databases

    InterProiIPR006737. Motilin_assoc.
    IPR006738. Motilin_ghrelin.
    IPR005441. Preproghrelin.
    [Graphical view]
    PANTHERiPTHR14122. PTHR14122. 1 hit.
    PfamiPF04643. Motilin_assoc. 1 hit.
    PF04644. Motilin_ghrelin. 1 hit.
    [Graphical view]
    PRINTSiPR01624. GHRELIN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BDJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAPWTICSL LLLSVLCMDL AMAGSSFLSP EHQKLQRKEA KKPSGRLKPR    50
    TLEGQFDPEV GSQAEGAEDE LEIRFNAPFN IGIKLAGAQS LQHGQTLGKF 100
    LQDILWEEAE ETLANE 116
    Length:116
    Mass (Da):12,793
    Last modified:June 1, 2001 - v1
    Checksum:iF55536DAC5FA59B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341K → E in BAB19047. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF350329 mRNA. Translation: AAK18612.1.
    AY903701 Genomic DNA. Translation: AAX89508.1.
    AB035702 mRNA. Translation: BAB19047.1.
    RefSeqiNP_776492.1. NM_174067.2.
    UniGeneiBt.8142.

    Genome annotation databases

    EnsembliENSBTAT00000016350; ENSBTAP00000016350; ENSBTAG00000012328.
    GeneIDi281192.
    KEGGibta:281192.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Gut feelings - Issue 66 of January 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF350329 mRNA. Translation: AAK18612.1 .
    AY903701 Genomic DNA. Translation: AAX89508.1 .
    AB035702 mRNA. Translation: BAB19047.1 .
    RefSeqi NP_776492.1. NM_174067.2.
    UniGenei Bt.8142.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000016350 ; ENSBTAP00000016350 ; ENSBTAG00000012328 .
    GeneIDi 281192.
    KEGGi bta:281192.

    Organism-specific databases

    CTDi 51738.

    Phylogenomic databases

    eggNOGi NOG45924.
    GeneTreei ENSGT00390000004064.
    HOGENOMi HOG000236303.
    HOVERGENi HBG018522.
    KOi K05254.

    Enzyme and pathway databases

    Reactomei REACT_209521. G alpha (q) signalling events.
    REACT_219025. Peptide ligand-binding receptors.
    REACT_223503. Synthesis, secretion, and deacylation of Ghrelin.

    Miscellaneous databases

    NextBioi 20805249.

    Family and domain databases

    InterProi IPR006737. Motilin_assoc.
    IPR006738. Motilin_ghrelin.
    IPR005441. Preproghrelin.
    [Graphical view ]
    PANTHERi PTHR14122. PTHR14122. 1 hit.
    Pfami PF04643. Motilin_assoc. 1 hit.
    PF04644. Motilin_ghrelin. 1 hit.
    [Graphical view ]
    PRINTSi PR01624. GHRELIN.
    ProtoNeti Search...

    Publicationsi

    1. Kita K., Harada K., Yokota H.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A full length genomic sequence of the bovine ghrelin gene."
      Li C., Lobo S., Wang Z., Fu A., Meng Y., Murdoch B., Hansen C., Moore S.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Kojima M.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-99.

    Entry informationi

    Entry nameiGHRL_BOVIN
    AccessioniPrimary (citable) accession number: Q9BDJ6
    Secondary accession number(s): Q0VH85, Q9GKY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3