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Protein

Appetite-regulating hormone

Gene

GHRL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).By similarity
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-BTA-416476 G alpha (q) signalling events
R-BTA-422085 Synthesis, secretion, and deacylation of Ghrelin

Names & Taxonomyi

Protein namesi
Recommended name:
Appetite-regulating hormone
Alternative name(s):
Growth hormone secretagogue
Growth hormone-releasing peptide
Motilin-related peptide
Cleaved into the following 2 chains:
Gene namesi
Name:GHRL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:29351 GHRL

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PeptideiPRO_000001919424 – 50GhrelinBy similarityAdd BLAST27
PropeptideiPRO_000001919551 – 74Removed in mature formBy similarityAdd BLAST24
PeptideiPRO_000004513275 – 97ObestatinBy similarityAdd BLAST23
PropeptideiPRO_000004513398 – 116Removed in mature formBy similarityAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi26O-octanoyl serineBy similarity1
Modified residuei97Leucine amideBy similarity1

Post-translational modificationi

O-octanoylation is essential for ghrelin activity.By similarity
Amidation of Leu-97 is essential for obestatin activity.By similarity

Keywords - PTMi

Amidation, Lipoprotein

Proteomic databases

PaxDbiQ9BDJ6
PRIDEiQ9BDJ6

Expressioni

Gene expression databases

BgeeiENSBTAG00000012328
ExpressionAtlasiQ9BDJ6 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041811

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZYV Eukaryota
ENOG410ZG1B LUCA
GeneTreeiENSGT00390000004064
HOGENOMiHOG000236303
HOVERGENiHBG018522
InParanoidiQ9BDJ6
KOiK05254

Family and domain databases

InterProiView protein in InterPro
IPR006737 Motilin_assoc
IPR006738 Motilin_ghrelin
IPR005441 Preproghrelin
PANTHERiPTHR14122 PTHR14122, 1 hit
PfamiView protein in Pfam
PF04643 Motilin_assoc, 1 hit
PF04644 Motilin_ghrelin, 1 hit
PRINTSiPR01624 GHRELIN

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BDJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPWTICSL LLLSVLCMDL AMAGSSFLSP EHQKLQRKEA KKPSGRLKPR
60 70 80 90 100
TLEGQFDPEV GSQAEGAEDE LEIRFNAPFN IGIKLAGAQS LQHGQTLGKF
110
LQDILWEEAE ETLANE
Length:116
Mass (Da):12,793
Last modified:June 1, 2001 - v1
Checksum:iF55536DAC5FA59B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34K → E in BAB19047 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350329 mRNA Translation: AAK18612.1
AY903701 Genomic DNA Translation: AAX89508.1
AB035702 mRNA Translation: BAB19047.1
RefSeqiNP_776492.1, NM_174067.2
UniGeneiBt.8142

Genome annotation databases

EnsembliENSBTAT00000016350; ENSBTAP00000016350; ENSBTAG00000012328
GeneIDi281192
KEGGibta:281192

Similar proteinsi

Entry informationi

Entry nameiGHRL_BOVIN
AccessioniPrimary (citable) accession number: Q9BDJ6
Secondary accession number(s): Q0VH85, Q9GKY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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