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Q9BDE0

- TYRO_GORGO

UniProt

Q9BDE0 - TYRO_GORGO

Protein

Tyrosinase

Gene

TYR

Organism
Gorilla gorilla gorilla (Lowland gorilla)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi180 – 1801Copper ABy similarity
    Metal bindingi202 – 2021Copper ABy similarity
    Metal bindingi211 – 2111Copper ABy similarity
    Metal bindingi363 – 3631Copper BBy similarity
    Metal bindingi367 – 3671Copper BBy similarity
    Metal bindingi390 – 3901Copper BBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. monophenol monooxygenase activity Source: UniProtKB-EC
    3. protein heterodimerization activity Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:TYR
    OrganismiGorilla gorilla gorilla (Lowland gorilla)
    Taxonomic identifieri9595 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
    ProteomesiUP000001519: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. melanosome Source: UniProtKB
    3. melanosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in TYR are the cause of oculocutaneous albinism (OCA). The only known albino gorilla, called Floquet de Neu ('Snowflake') had white hair, pink skin and blue eyes (zoologic park of Barcelona, 1964-2003). No differences were found at the amino-acid level but the activity of this enzyme was lacking in 'Snowflake'.

    Keywords - Diseasei

    Albinism

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 529511TyrosinasePRO_0000035878Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BDE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 476458Lumenal, melanosomeSequence AnalysisAdd
    BLAST
    Topological domaini498 – 52932CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei477 – 49721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG003553.

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BDE0-1 [UniParc]FASTAAdd to Basket

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    MLLAVLYCLL WSFQTSAGHF PRACVSSKNL MEKECCPPWS GDRSPCGQLS    50
    GRGSCQNILL SNAPLGPQFP FTGVDDRESW PSVFYNRTCQ CSGNFMGFNC 100
    GNCKFGFWGP NCTERRLLVR RNIFDLSAPE KDKFFAYLTL AKHTISSDYV 150
    IPIGTYGQMK NGSTPMFNDI NIYDLFVWMH YYVSMDALLG GSEIWRDIDF 200
    AHEAPAFLPW HRLFLLRWEQ EIQKLTGDEN FTIPYWDWRD AEKCDICTDE 250
    YMGGQHPTNP NLLSPASFFS SWQIVCSRLE EYNSHQSLCN GTPEGPLQRN 300
    PGNHDKSRTP RLPSSADVEF CLSLTQYESG SMDKAANFSF RNTLEGFASP 350
    LTGIADASQS SMHNALHIYM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW 400
    LRRHRPLQEV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDLGYDYS 450
    YLQDSDPDSF QDYIKSYLEQ ASRIWSWLLG AAMVGAVLTA LLAGLVSLLC 500
    RHKRKQLPEE KQPLLMEKED YHSLYQSHL 529
    Length:529
    Mass (Da):60,365
    Last modified:June 7, 2004 - v2
    Checksum:iD1C574D63DFF8EBC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51V → A in AAG27271. 1 PublicationCurated
    Sequence conflicti5 – 51V → I in AAX82902. 1 PublicationCurated
    Sequence conflicti5 – 51V → I in AAX82905. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF237806
    , AF237802, AF237803, AF237804, AF237805 Genomic DNA. Translation: AAK00804.1.
    AF237796
    , AF237792, AF237793, AF237794, AF237795 Genomic DNA. Translation: AAK00802.1.
    AF237801
    , AF237797, AF237798, AF237799, AF237800 Genomic DNA. Translation: AAK00803.1.
    AY874469
    , AY874465, AY874466, AY874468, AY874467 Genomic DNA. Translation: AAX82902.1.
    AY874464
    , AY874460, AY874462, AY874463, AY874461 Genomic DNA. Translation: AAX82905.1.
    AF183601, AF183599, AF183600 Genomic DNA. Translation: AAG27271.1.
    AF183603, AF183602 Genomic DNA. Translation: AAG27272.1.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Snowy stardom - Issue 49 of August 2004

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF237806
    , AF237802 , AF237803 , AF237804 , AF237805 Genomic DNA. Translation: AAK00804.1 .
    AF237796
    , AF237792 , AF237793 , AF237794 , AF237795 Genomic DNA. Translation: AAK00802.1 .
    AF237801
    , AF237797 , AF237798 , AF237799 , AF237800 Genomic DNA. Translation: AAK00803.1 .
    AY874469
    , AY874465 , AY874466 , AY874468 , AY874467 Genomic DNA. Translation: AAX82902.1 .
    AY874464
    , AY874460 , AY874462 , AY874463 , AY874461 Genomic DNA. Translation: AAX82905.1 .
    AF183601 , AF183599 , AF183600 Genomic DNA. Translation: AAG27271.1 .
    AF183603 , AF183602 Genomic DNA. Translation: AAG27272.1 .

    3D structure databases

    ProteinModelPortali Q9BDE0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG003553.

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN ALBINISM.
      Strain: Isolate Machinda, Isolate Ndengue and Isolate Snowflake.
      Tissue: Blood.
    2. "Analysis of 5' upstream regulatory sequences and LCR-like region of the Gorilla tyrosinase locus."
      Roy R., Cantero M., Montoliu L.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Isolate Snowflake and Isolate Urko.
    3. "Molecular evolution of tyrosinase gene in primates."
      Ding B., Ryder O.A., Shi P., Zhang Y.-P.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-388 AND 396-529.

    Entry informationi

    Entry nameiTYRO_GORGO
    AccessioniPrimary (citable) accession number: Q9BDE0
    Secondary accession number(s): Q2KP17, Q9GLU5, Q9GLU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3