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Protein
Submitted name:

H2-T22 protein

Gene

H2-T22

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-1236974. ER-Phagosome pathway.
R-MMU-1236977. Endosomal/Vacuolar pathway.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
H2-T22 proteinImported
Submitted name:
Histocompatibility 2, T region locus 22Imported
Gene namesi
Name:H2-T22Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95956. H2-T22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501014781520 – 344Sequence analysisAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi126 ↔ 176Combined sources
Disulfide bondi135 ↔ 158Combined sources
Disulfide bondi215 ↔ 271Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000056116.

Interactioni

Protein-protein interaction databases

IntActiQ9BCZ1. 1 interactor.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YPZX-ray3.40A/C29-288[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 275Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BCZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWVLRAAVV CALLLQLDAR PSWTRIPLGS HSLRYFYTAV SRPGLGEPWF
60 70 80 90 100
IIVGYVDDMQ VLRFSSKEET PRMAPWLEQE EADNWEQQTR IVTIQGQLSE
110 120 130 140 150
RNLMTLVHFY NKSMDDSHTL QWLQGCDVEP DRHLCLWYNQ LAYDSEDLPT
160 170 180 190 200
LNENPSSCTV GNSTVPHISQ DLKSHCSDLL QKYLEKGKER LLRSDPPKAH
210 220 230 240 250
VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEELTQDM ELVETRPAGD
260 270 280 290 300
GTFQKWAAVV VPLGKEQSYT CHVYHEGLPE PLILRWGGRG RRDTQEAGRD
310 320 330 340
SPQDSSKTVV DDEEMGVCFW KIKSCKTCLG HSPGTSVGES LLSP
Length:344
Mass (Da):39,100
Last modified:June 1, 2001 - v1
Checksum:iA8FE34EE998E614C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112970 Genomic DNA. No translation available.
BC003819 mRNA. Translation: AAH03819.1.
RefSeqiNP_001334311.1. NM_001347382.1.
XP_017172753.1. XM_017317264.1.
UniGeneiMm.195061.

Genome annotation databases

EnsembliENSMUST00000058801; ENSMUSP00000056041; ENSMUSG00000056116.
GeneIDi15039.
UCSCiuc008cjv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112970 Genomic DNA. No translation available.
BC003819 mRNA. Translation: AAH03819.1.
RefSeqiNP_001334311.1. NM_001347382.1.
XP_017172753.1. XM_017317264.1.
UniGeneiMm.195061.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YPZX-ray3.40A/C29-288[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BCZ1. 1 interactor.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058801; ENSMUSP00000056041; ENSMUSG00000056116.
GeneIDi15039.
UCSCiuc008cjv.1. mouse.

Organism-specific databases

CTDi15039.
MGIiMGI:95956. H2-T22.

Phylogenomic databases

GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.

Enzyme and pathway databases

ReactomeiR-MMU-1236974. ER-Phagosome pathway.
R-MMU-1236977. Endosomal/Vacuolar pathway.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056116.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9BCZ1_MOUSE
AccessioniPrimary (citable) accession number: Q9BCZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.