Q9B8D8 (COX2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	COX2
ORF Names:	CaalfMp01

Encoded on

Mitochondrion

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, cytochrome c to oxygen Inferred from sequence or structural similarity PubMed 15449175. Source: CGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex IV Inferred from sequence or structural similarity PubMed 15449175. Source: CGD
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from sequence or structural similarity PubMed 15449175. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cytochrome c oxidase subunit 2		PRO_0000356868
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	72 – 92	21	Helical; Potential
Sites
	Metal binding	175	1	Copper A By similarity
	Metal binding	210	1	Copper A By similarity
	Metal binding	214	1	Copper A By similarity
	Metal binding	218	1	Copper A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9B8D8 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: A2DAA5432C735EB3	FASTA	262	29,859
	10 20 30 40 50 60 MIRLDVPTPW GIRLQDSATP NAEGIHELYD HIMFYLCLIL GLVSYILYVI IKDYKDNRFA 70 80 90 100 110 120 YKYVRHGQVI EIIWTIFPAV ILLLIAFPSF ILLYLCDEVL TPAMTIKVIG LQWYWKYEYS 130 140 150 160 170 180 DFVDSIGETI EFESYVIPDD MLEPGALRLL DTDTSIVVPV DTHIRFVVTA NDVIHSFTIP 190 200 210 220 230 240 SLGMKIDATP GRLNQVSALI QRTGVYYGQC SELCGVNHGM MPIKLECVSI EDFIEWLGEN 250 260 EVSLNSSMVE QCTVNALILV QF

References

[1]

"Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans." Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M. J. Bacteriol. 183:865-872(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF285261 Genomic DNA. Translation: AAG59600.2.
RefSeq	NP_075030.2. NC_002653.1.
3D structure databases
ProteinModelPortal	Q9B8D8.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAF0007359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	802565.
KEGG	cal:CaalfMp01.
Organism-specific databases
CGD	CAF0007359. COX2.
Phylogenomic databases
eggNOG	COG1622.
HOGENOM	HOG000264988.
KO	K02261.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_CANAL

Accession

Primary (citable) accession number: Q9B8D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program