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Q9B8D8 (COX2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
ORF Names:CaalfMp01
Encoded onMitochondrion
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cytochrome c oxidase subunit 2
PRO_0000356868

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane72 – 9221Helical; Potential

Sites

Metal binding1751Copper A By similarity
Metal binding2101Copper A By similarity
Metal binding2141Copper A By similarity
Metal binding2181Copper A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9B8D8 [UniParc].

Last modified October 1, 2003. Version 2.
Checksum: A2DAA5432C735EB3

FASTA26229,859
        10         20         30         40         50         60 
MIRLDVPTPW GIRLQDSATP NAEGIHELYD HIMFYLCLIL GLVSYILYVI IKDYKDNRFA 

        70         80         90        100        110        120 
YKYVRHGQVI EIIWTIFPAV ILLLIAFPSF ILLYLCDEVL TPAMTIKVIG LQWYWKYEYS 

       130        140        150        160        170        180 
DFVDSIGETI EFESYVIPDD MLEPGALRLL DTDTSIVVPV DTHIRFVVTA NDVIHSFTIP 

       190        200        210        220        230        240 
SLGMKIDATP GRLNQVSALI QRTGVYYGQC SELCGVNHGM MPIKLECVSI EDFIEWLGEN 

       250        260 
EVSLNSSMVE QCTVNALILV QF 

« Hide

References

[1]"Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans."
Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M.
J. Bacteriol. 183:865-872(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF285261 Genomic DNA. Translation: AAG59600.2.
RefSeqNP_075030.2. NC_002653.1.

3D structure databases

ProteinModelPortalQ9B8D8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAF0007359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID802565.
KEGGcal:CaalfMp01.

Organism-specific databases

CGDCAF0007359. COX2.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02261.
OrthoDBEOG7WDNDC.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CANAL
AccessionPrimary (citable) accession number: Q9B8D8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names