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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds a copper A center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175Copper ABy similarity1
Metal bindingi210Copper ABy similarity1
Metal bindingi214Copper ABy similarity1
Metal bindingi218Copper ABy similarity1

GO - Molecular functioni

  • copper ion binding Source: InterPro
  • cytochrome-c oxidase activity Source: CGD

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: CGD

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Ordered Locus Names:CM_00030WImported
ORF Names:CaalfMp01
Encoded oniMitochondrion
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Mitochondrion

Organism-specific databases

CGDiCAL0000186073 COX2
EuPathDBiFungiDB:CM_00030W

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003568681 – 262Cytochrome c oxidase subunit 2Add BLAST262

Proteomic databases

PRIDEiQ9B8D8

Structurei

3D structure databases

ProteinModelPortaliQ9B8D8
SMRiQ9B8D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988
InParanoidiQ9B8D8
KOiK02261
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9B8D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLDVPTPW GIRLQDSATP NAEGIHELYD HIMFYLCLIL GLVSYILYVI
60 70 80 90 100
IKDYKDNRFA YKYVRHGQVI EIIWTIFPAV ILLLIAFPSF ILLYLCDEVL
110 120 130 140 150
TPAMTIKVIG LQWYWKYEYS DFVDSIGETI EFESYVIPDD MLEPGALRLL
160 170 180 190 200
DTDTSIVVPV DTHIRFVVTA NDVIHSFTIP SLGMKIDATP GRLNQVSALI
210 220 230 240 250
QRTGVYYGQC SELCGVNHGM MPIKLECVSI EDFIEWLGEN EVSLNSSMVE
260
QCTVNALILV QF
Length:262
Mass (Da):29,859
Last modified:October 1, 2003 - v2
Checksum:iA2DAA5432C735EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA Translation: AAG59600.2
RefSeqiNP_075030.2, NC_002653.1

Genome annotation databases

GeneIDi802565
KEGGical:CaalfMp01

Similar proteinsi

Entry informationi

Entry nameiCOX2_CANAL
AccessioniPrimary (citable) accession number: Q9B8D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health