Reviewed, UniProtKB/Swiss-Prot Q9B8D4 (ATP6_CANAL)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit a
Alternative name(s):
    F-ATPase protein 6
    ATP synthase subunit 6

Gene names

Name:	ATP6
ORF Names:	CaalfMp06

Encoded on

Mitochondrion

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 3	3	Removed in mature form By similarity		PRO_0000356862
	Chain	4 – 246	243	ATP synthase subunit a		PRO_0000356863
Regions
	Transmembrane	20 – 40	21	Potential
	Transmembrane	56 – 76	21	Potential
	Transmembrane	82 – 102	21	Potential
	Transmembrane	112 – 132	21	Potential
	Transmembrane	138 – 158	21	Potential
	Transmembrane	176 – 196	21	Potential
	Transmembrane	203 – 223	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9B8D4-1 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: BC14AFBF0622DE96	FASTA	246	26,568
	10 20 30 40 50 60 MFYSPLDQFE IKPLLMVNNI LTLALTNYTL YLIIVVSIIF GYTSIISNGR LGSTRWGVAI 70 80 90 100 110 120 IAIYDTILNL VYSQIGKAGG HFFPLIFTIF NLIFAANLIS MIPYSFAISA QLVAIVSFSL 130 140 150 160 170 180 ALWIGNVILG LYLHGWGFFA LFVPSGTPLP LVPILVLIEA LSYSSRAISL GLRLGANILS 190 200 210 220 230 240 GHLLMLILGS LIVNLMSSSI LGFIGGIVPI VAVIAITILE VGIAIIQAYV FSILLSGYIK DSVSLH

References

[1]

"Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans." Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M. J. Bacteriol. 183:865-872(2001) [PubMed: 11208783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF285261 Genomic DNA. Translation: AAG59592.2.
RefSeq	NP_075035.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	802560.
KEGG	cal:CaalfMp06.
Organism-specific databases
CGD	CAF0007372. ATP6.
Phylogenomic databases
HOGENOM	HBG734175.
OrthoDB	EOG9KM0K3.
Family and domain databases
InterPro	IPR000568. ATPase_F0-cplx_asu. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_CANAL

Accession

Primary (citable) accession number: Q9B8D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	October 1, 2003
Last modified:	December 15, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)