Reviewed, UniProtKB/Swiss-Prot Q9B8D3 (ATP8_CANAL)

Names and origin

Protein names

Recommended name:
    ATP synthase protein 8
Alternative name(s):
    F-ATPase subunit 8
    A6L

Gene names

Name:	ATP8
ORF Names:	CaalfMp07

Encoded on

Mitochondrion

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	48 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane By similarity.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel By similarity.
Subcellular location	Mitochondrion membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the ATPase protein 8 family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion
Domain	Transmembrane
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 48	48	ATP synthase protein 8		PRO_0000356860
Regions
	Transmembrane	12 – 32	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9B8D3-1 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: E9D6F37787496D51	FASTA	48	5,352
	10 20 30 40 MPQLVPFYWM NLLTTGIAAV SILLYLSATI ILPNVLRLLV ARAIIVRV

References

[1]

"Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans." Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M. J. Bacteriol. 183:865-872(2001) [PubMed: 11208783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF285261 Genomic DNA. Translation: AAG59593.2.
RefSeq	NP_075036.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	802553.
KEGG	cal:CaalfMp07.
Organism-specific databases
CGD	CAF0007373. ATP8.
Phylogenomic databases
HOGENOM	HBG398772.
OrthoDB	EOG99GN01.
Family and domain databases
InterPro	IPR009230. ATPase_F0-cplx_su8_mt_fun. [Graphical view]
Pfam	PF05933. Fun_ATP-synt_8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP8_CANAL

Accession

Primary (citable) accession number: Q9B8D3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	October 1, 2003
Last modified:	December 15, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)