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Q9B840

- COX1_OSTNU

UniProt

Q9B840 - COX1_OSTNU

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Ostrinia nubilalis (European corn borer) (Pyralis nubilalis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiOstrinia nubilalis (European corn borer) (Pyralis nubilalis)
    Taxonomic identifieri29057 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaCrambidaePyraustinaeOstrinia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000183376Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9B840.
    SMRiQ9B840. Positions 4-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9B840-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKWLYSTN HKDIGTLYFI FGIWSGMVGT SLSLLIRAEL GNPGSLIGDD    50
    QIYNTIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS 100
    FWLLPPSLTL LISSSIVENG AGTGWTVYPP LSSNIAHGGS SVDLAIFSLH 150
    LAGITSILGA INFITTIINM RINGMSFDQM PLFVWSVGIT ALLLLLSLPV 200
    LAGAFTMLTT DRNLNTSFFD PAGGEILFYI QHLFWFFGHP EVYILILPGF 250
    GMISMLFHKK EEKKKHFGSL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT 300
    RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSILWS LGFVFLFTVG 350
    GLTGVVLANP SIDIALHDTY YVVAHFHYVL SMGAVFAIIA GFIHWYPLFT 400
    GLSLNPYFLK IQFFTMFIGV NLTFFPQHFL GLAGMPRRYS DYPDAYISWN 450
    IISSLGSYIS LLAVMLILII IWESMINQRM ILFSLNLTSS MEWYKSKLPP 500
    AEHSYNELPI LSNF 514
    Length:514
    Mass (Da):57,395
    Last modified:June 1, 2001 - v1
    Checksum:i55803C86A9C5AFFE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti155 – 1551T → S in haplotype 2.
    Natural varianti206 – 2061T → A in haplotype 2.
    Natural varianti491 – 4911M → I in haplotype 2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321878 Genomic DNA. Translation: AAK00951.1.
    AF321879 Genomic DNA. Translation: AAK00952.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321878 Genomic DNA. Translation: AAK00951.1 .
    AF321879 Genomic DNA. Translation: AAK00952.1 .

    3D structure databases

    ProteinModelPortali Q9B840.
    SMRi Q9B840. Positions 4-507.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ostrinia nubilalis cytochrome c oxidase haplotype variation."
      Coates B.S., Hellmich R.L., Lewis L.C.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Haplotype 2 and haplotype 3.

    Entry informationi

    Entry nameiCOX1_OSTNU
    AccessioniPrimary (citable) accession number: Q9B840
    Secondary accession number(s): Q9B841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3