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Q9B840 (COX1_OSTNU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismOstrinia nubilalis (European corn borer) (Pyralis nubilalis)
Taxonomic identifier29057 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaCrambidaePyraustinaeOstrinia

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Cytochrome c oxidase subunit 1
PRO_0000183376

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane267 – 28721Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane337 – 35721Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane413 – 43321Helical; Potential
Transmembrane451 – 47121Helical; Potential

Natural variations

Natural variant1551T → S in haplotype 2.
Natural variant2061T → A in haplotype 2.
Natural variant4911M → I in haplotype 2.

Sequences

Sequence LengthMass (Da)Tools
Q9B840 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 55803C86A9C5AFFE

FASTA51457,395
        10         20         30         40         50         60 
MSRKWLYSTN HKDIGTLYFI FGIWSGMVGT SLSLLIRAEL GNPGSLIGDD QIYNTIVTAH 

        70         80         90        100        110        120 
AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS FWLLPPSLTL LISSSIVENG 

       130        140        150        160        170        180 
AGTGWTVYPP LSSNIAHGGS SVDLAIFSLH LAGITSILGA INFITTIINM RINGMSFDQM 

       190        200        210        220        230        240 
PLFVWSVGIT ALLLLLSLPV LAGAFTMLTT DRNLNTSFFD PAGGEILFYI QHLFWFFGHP 

       250        260        270        280        290        300 
EVYILILPGF GMISMLFHKK EEKKKHFGSL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT 

       310        320        330        340        350        360 
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSILWS LGFVFLFTVG GLTGVVLANP 

       370        380        390        400        410        420 
SIDIALHDTY YVVAHFHYVL SMGAVFAIIA GFIHWYPLFT GLSLNPYFLK IQFFTMFIGV 

       430        440        450        460        470        480 
NLTFFPQHFL GLAGMPRRYS DYPDAYISWN IISSLGSYIS LLAVMLILII IWESMINQRM 

       490        500        510 
ILFSLNLTSS MEWYKSKLPP AEHSYNELPI LSNF 

« Hide

References

[1]"Ostrinia nubilalis cytochrome c oxidase haplotype variation."
Coates B.S., Hellmich R.L., Lewis L.C.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Haplotype 2 and haplotype 3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321878 Genomic DNA. Translation: AAK00951.1.
AF321879 Genomic DNA. Translation: AAK00952.1.

3D structure databases

ProteinModelPortalQ9B840.
SMRQ9B840. Positions 4-507.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_OSTNU
AccessionPrimary (citable) accession number: Q9B840
Secondary accession number(s): Q9B841
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways