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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Ostrinia nubilalis (European corn borer) (Pyralis nubilalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiOstrinia nubilalis (European corn borer) (Pyralis nubilalis)
Taxonomic identifieri29057 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPyraloideaCrambidaePyraustinaeOstrinia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000183376Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9B840.
SMRiQ9B840. Positions 4-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKWLYSTN HKDIGTLYFI FGIWSGMVGT SLSLLIRAEL GNPGSLIGDD
60 70 80 90 100
QIYNTIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS
110 120 130 140 150
FWLLPPSLTL LISSSIVENG AGTGWTVYPP LSSNIAHGGS SVDLAIFSLH
160 170 180 190 200
LAGITSILGA INFITTIINM RINGMSFDQM PLFVWSVGIT ALLLLLSLPV
210 220 230 240 250
LAGAFTMLTT DRNLNTSFFD PAGGEILFYI QHLFWFFGHP EVYILILPGF
260 270 280 290 300
GMISMLFHKK EEKKKHFGSL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT
310 320 330 340 350
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSILWS LGFVFLFTVG
360 370 380 390 400
GLTGVVLANP SIDIALHDTY YVVAHFHYVL SMGAVFAIIA GFIHWYPLFT
410 420 430 440 450
GLSLNPYFLK IQFFTMFIGV NLTFFPQHFL GLAGMPRRYS DYPDAYISWN
460 470 480 490 500
IISSLGSYIS LLAVMLILII IWESMINQRM ILFSLNLTSS MEWYKSKLPP
510
AEHSYNELPI LSNF
Length:514
Mass (Da):57,395
Last modified:May 31, 2001 - v1
Checksum:i55803C86A9C5AFFE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti155 – 1551T → S in haplotype 2.
Natural varianti206 – 2061T → A in haplotype 2.
Natural varianti491 – 4911M → I in haplotype 2.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321878 Genomic DNA. Translation: AAK00951.1.
AF321879 Genomic DNA. Translation: AAK00952.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321878 Genomic DNA. Translation: AAK00951.1.
AF321879 Genomic DNA. Translation: AAK00952.1.

3D structure databases

ProteinModelPortaliQ9B840.
SMRiQ9B840. Positions 4-507.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ostrinia nubilalis cytochrome c oxidase haplotype variation."
    Coates B.S., Hellmich R.L., Lewis L.C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Haplotype 2 and haplotype 3.

Entry informationi

Entry nameiCOX1_OSTNU
AccessioniPrimary (citable) accession number: Q9B840
Secondary accession number(s): Q9B841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2003
Last sequence update: May 31, 2001
Last modified: January 6, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.