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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Ostrinia nubilalis (European corn borer) (Pyralis nubilalis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiOstrinia nubilalis (European corn borer) (Pyralis nubilalis)
Taxonomic identifieri29057 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaPyraloideaCrambidaePyraustinaeOstrinia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833761 – 514Cytochrome c oxidase subunit 1Add BLAST514

Structurei

3D structure databases

ProteinModelPortaliQ9B840
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9B840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKWLYSTN HKDIGTLYFI FGIWSGMVGT SLSLLIRAEL GNPGSLIGDD
60 70 80 90 100
QIYNTIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS
110 120 130 140 150
FWLLPPSLTL LISSSIVENG AGTGWTVYPP LSSNIAHGGS SVDLAIFSLH
160 170 180 190 200
LAGITSILGA INFITTIINM RINGMSFDQM PLFVWSVGIT ALLLLLSLPV
210 220 230 240 250
LAGAFTMLTT DRNLNTSFFD PAGGEILFYI QHLFWFFGHP EVYILILPGF
260 270 280 290 300
GMISMLFHKK EEKKKHFGSL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT
310 320 330 340 350
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSILWS LGFVFLFTVG
360 370 380 390 400
GLTGVVLANP SIDIALHDTY YVVAHFHYVL SMGAVFAIIA GFIHWYPLFT
410 420 430 440 450
GLSLNPYFLK IQFFTMFIGV NLTFFPQHFL GLAGMPRRYS DYPDAYISWN
460 470 480 490 500
IISSLGSYIS LLAVMLILII IWESMINQRM ILFSLNLTSS MEWYKSKLPP
510
AEHSYNELPI LSNF
Length:514
Mass (Da):57,395
Last modified:June 1, 2001 - v1
Checksum:i55803C86A9C5AFFE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti155T → S in haplotype 2. 1
Natural varianti206T → A in haplotype 2. 1
Natural varianti491M → I in haplotype 2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321878 Genomic DNA Translation: AAK00951.1
AF321879 Genomic DNA Translation: AAK00952.1

Entry informationi

Entry nameiCOX1_OSTNU
AccessioniPrimary (citable) accession number: Q9B840
Secondary accession number(s): Q9B841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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