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Q9B6E7

- COX1_YARLI

UniProt

Q9B6E7 - COX1_YARLI

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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Iron (heme A axial ligand)By similarity
Metal bindingi246 – 2461Copper BBy similarity
Metal bindingi250 – 2501Copper BBy similarity
Metal bindingi295 – 2951Copper BBy similarity
Metal bindingi296 – 2961Copper BBy similarity
Metal bindingi381 – 3811Iron (heme A3 axial ligand)By similarity
Metal bindingi383 – 3831Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4323HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8523HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 12823HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17523HelicalSequence AnalysisAdd
BLAST
Transmembranei188 – 21023HelicalSequence AnalysisAdd
BLAST
Transmembranei242 – 26423HelicalSequence AnalysisAdd
BLAST
Transmembranei271 – 29323HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36423HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 40123HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43623HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47823HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Cytochrome c oxidase subunit 1PRO_0000183431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi4952.Q9B6E7.

Structurei

3D structure databases

ProteinModelPortaliQ9B6E7.
SMRiQ9B6E7. Positions 7-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
InParanoidiQ9B6E7.
KOiK02256.
OrthoDBiEOG72C58S.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B6E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLKLNIQRW LFSTNAKDIA VLYFIFALFS AMIGTGLSAI IRLELANTGS
60 70 80 90 100
PFLHGNTQAF NVVITAHAIL MIFFFVMPAL VGGFGNYLMP LMLGASDMAF
110 120 130 140 150
ARLNNISFWL LVPSLILILT SALVEAGAGT GWTVYFPLAG IQSHSGPAVD
160 170 180 190 200
LAIFSLHLSG FSSLLGAINF ITTFINMRTI GMKYENVPLF AWAVLFTAIL
210 220 230 240 250
LLLSLPVLAA GLTMGIFDRN FNTSFFEYAG GGDAVLYQHL FYWWNHPEVY
260 270 280 290 300
ILIIPGFGII SHAVSAIASK PVFGVQGMIY AMWSIGLLGF CVWSHHMFAV
310 320 330 340 350
GLDSDTRAYF TSATMVIAVP TSIKIFSWLA TLYGGTIRLN VTALFALGFI
360 370 380 390 400
FLFTIGGLTG VVLANSALDI PFHDSYYVVA HFHYVLSMGA VFSIFCGWYL
410 420 430 440 450
WSPKILGLHY NERLSHIHFW LMFIGVNVTF FPMHFLGLQG MPRRINDYPD
460 470 480 490 500
AFIGWNQVAS LGSIISIVAS IVFIYVVYDQ LTNGLHQGNK ALDSQFKPSF
510 520 530
MGTNLNVEGY TGPTLEWTVS TPPSLHAFNT PAVLY
Length:535
Mass (Da):58,935
Last modified:June 1, 2001 - v1
Checksum:iB47B1E3FD4AF9577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA. Translation: CAC28091.2.
RefSeqiNP_075425.2. NC_002659.1.

Genome annotation databases

GeneIDi802596.
KEGGiyli:YalifMp03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA. Translation: CAC28091.2 .
RefSeqi NP_075425.2. NC_002659.1.

3D structure databases

ProteinModelPortali Q9B6E7.
SMRi Q9B6E7. Positions 7-533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q9B6E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 802596.
KEGGi yli:YalifMp03.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
InParanoidi Q9B6E7.
KOi K02256.
OrthoDBi EOG72C58S.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial genome of Yarrowia lipolytica."
    Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.
    Comp. Funct. Genomics 2:80-90(2001)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.

Entry informationi

Entry nameiCOX1_YARLI
AccessioniPrimary (citable) accession number: Q9B6E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3