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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron (heme A axial ligand)By similarity1
Metal bindingi246Copper BBy similarity1
Metal bindingi250Copper BBy similarity1
Metal bindingi295Copper BBy similarity1
Metal bindingi296Copper BBy similarity1
Metal bindingi381Iron (heme A3 axial ligand)By similarity1
Metal bindingi383Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 43HelicalSequence analysisAdd BLAST23
Transmembranei63 – 85HelicalSequence analysisAdd BLAST23
Transmembranei106 – 128HelicalSequence analysisAdd BLAST23
Transmembranei153 – 175HelicalSequence analysisAdd BLAST23
Transmembranei188 – 210HelicalSequence analysisAdd BLAST23
Transmembranei242 – 264HelicalSequence analysisAdd BLAST23
Transmembranei271 – 293HelicalSequence analysisAdd BLAST23
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei342 – 364HelicalSequence analysisAdd BLAST23
Transmembranei379 – 401HelicalSequence analysisAdd BLAST23
Transmembranei414 – 436HelicalSequence analysisAdd BLAST23
Transmembranei456 – 478HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834311 – 535Cytochrome c oxidase subunit 1Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9B6E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiQ9B6E7.
KOiK02256.
OrthoDBiEOG092C2KU4.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B6E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKLNIQRW LFSTNAKDIA VLYFIFALFS AMIGTGLSAI IRLELANTGS
60 70 80 90 100
PFLHGNTQAF NVVITAHAIL MIFFFVMPAL VGGFGNYLMP LMLGASDMAF
110 120 130 140 150
ARLNNISFWL LVPSLILILT SALVEAGAGT GWTVYFPLAG IQSHSGPAVD
160 170 180 190 200
LAIFSLHLSG FSSLLGAINF ITTFINMRTI GMKYENVPLF AWAVLFTAIL
210 220 230 240 250
LLLSLPVLAA GLTMGIFDRN FNTSFFEYAG GGDAVLYQHL FYWWNHPEVY
260 270 280 290 300
ILIIPGFGII SHAVSAIASK PVFGVQGMIY AMWSIGLLGF CVWSHHMFAV
310 320 330 340 350
GLDSDTRAYF TSATMVIAVP TSIKIFSWLA TLYGGTIRLN VTALFALGFI
360 370 380 390 400
FLFTIGGLTG VVLANSALDI PFHDSYYVVA HFHYVLSMGA VFSIFCGWYL
410 420 430 440 450
WSPKILGLHY NERLSHIHFW LMFIGVNVTF FPMHFLGLQG MPRRINDYPD
460 470 480 490 500
AFIGWNQVAS LGSIISIVAS IVFIYVVYDQ LTNGLHQGNK ALDSQFKPSF
510 520 530
MGTNLNVEGY TGPTLEWTVS TPPSLHAFNT PAVLY
Length:535
Mass (Da):58,935
Last modified:June 1, 2001 - v1
Checksum:iB47B1E3FD4AF9577
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA. Translation: CAC28091.2.
RefSeqiNP_075425.2. NC_002659.1.

Genome annotation databases

GeneIDi802596.
KEGGiyli:YalifMp03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA. Translation: CAC28091.2.
RefSeqiNP_075425.2. NC_002659.1.

3D structure databases

ProteinModelPortaliQ9B6E7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi802596.
KEGGiyli:YalifMp03.

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiQ9B6E7.
KOiK02256.
OrthoDBiEOG092C2KU4.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_YARLI
AccessioniPrimary (citable) accession number: Q9B6E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.