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Q9B6E7

- COX1_YARLI

UniProt

Q9B6E7 - COX1_YARLI

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi67 – 671Iron (heme A axial ligand)By similarity
    Metal bindingi246 – 2461Copper BBy similarity
    Metal bindingi250 – 2501Copper BBy similarity
    Metal bindingi295 – 2951Copper BBy similarity
    Metal bindingi296 – 2961Copper BBy similarity
    Metal bindingi381 – 3811Iron (heme A3 axial ligand)By similarity
    Metal bindingi383 – 3831Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Encoded oniMitochondrion
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Cytochrome c oxidase subunit 1PRO_0000183431Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q9B6E7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9B6E7.
    SMRiQ9B6E7. Positions 7-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 21023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 33023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 40123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02256.
    OrthoDBiEOG72C58S.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9B6E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLKLNIQRW LFSTNAKDIA VLYFIFALFS AMIGTGLSAI IRLELANTGS    50
    PFLHGNTQAF NVVITAHAIL MIFFFVMPAL VGGFGNYLMP LMLGASDMAF 100
    ARLNNISFWL LVPSLILILT SALVEAGAGT GWTVYFPLAG IQSHSGPAVD 150
    LAIFSLHLSG FSSLLGAINF ITTFINMRTI GMKYENVPLF AWAVLFTAIL 200
    LLLSLPVLAA GLTMGIFDRN FNTSFFEYAG GGDAVLYQHL FYWWNHPEVY 250
    ILIIPGFGII SHAVSAIASK PVFGVQGMIY AMWSIGLLGF CVWSHHMFAV 300
    GLDSDTRAYF TSATMVIAVP TSIKIFSWLA TLYGGTIRLN VTALFALGFI 350
    FLFTIGGLTG VVLANSALDI PFHDSYYVVA HFHYVLSMGA VFSIFCGWYL 400
    WSPKILGLHY NERLSHIHFW LMFIGVNVTF FPMHFLGLQG MPRRINDYPD 450
    AFIGWNQVAS LGSIISIVAS IVFIYVVYDQ LTNGLHQGNK ALDSQFKPSF 500
    MGTNLNVEGY TGPTLEWTVS TPPSLHAFNT PAVLY 535
    Length:535
    Mass (Da):58,935
    Last modified:June 1, 2001 - v1
    Checksum:iB47B1E3FD4AF9577
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ307410 Genomic DNA. Translation: CAC28091.2.
    RefSeqiNP_075425.2. NC_002659.1.

    Genome annotation databases

    GeneIDi802596.
    KEGGiyli:YalifMp03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ307410 Genomic DNA. Translation: CAC28091.2 .
    RefSeqi NP_075425.2. NC_002659.1.

    3D structure databases

    ProteinModelPortali Q9B6E7.
    SMRi Q9B6E7. Positions 7-533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q9B6E7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 802596.
    KEGGi yli:YalifMp03.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02256.
    OrthoDBi EOG72C58S.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial genome of Yarrowia lipolytica."
      Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.
      Comp. Funct. Genomics 2:80-90(2001)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.

    Entry informationi

    Entry nameiCOX1_YARLI
    AccessioniPrimary (citable) accession number: Q9B6E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3