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Q9B6D5 (COX2_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subunit structure

Composed of at least 11 subunits.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Cytochrome c oxidase subunit 2
PRO_0000006047

Regions

Topological domain7 – 3327Mitochondrial intermembrane Potential
Transmembrane34 – 5522Helical; Potential
Topological domain56 – 7318Mitochondrial matrix Potential
Transmembrane74 – 9825Helical; Potential
Topological domain99 – 242144Mitochondrial intermembrane Potential

Sites

Metal binding1771Copper A By similarity
Metal binding2121Copper A By similarity
Metal binding2161Copper A By similarity
Metal binding2201Copper A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9B6D5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 25A39C49A9262357

FASTA24227,636
        10         20         30         40         50         60 
MFKIFNDVPV PYGLYFQDSA TPTFDGIIEL HDIVMFYIVV TIVLVSYLLF VIIKNFSNDH 

        70         80         90        100        110        120 
ISYKYLTHGT TLEIVWTIFP VVILLFIAFP SFILLYLCDE VIDPAMTIKA IASQWYWTYE 

       130        140        150        160        170        180 
YSDFIGETGE IVQFDSYIVP TDMLENGQLR MLDVDARIVV PTNTHLRFIV TSRDVIHDFA 

       190        200        210        220        230        240 
LPSLGIKCDA TPGRLNQVSA LLQRESVYYG QCSELCGVLH SSMPIALEAV SIDKFLSWLD 


EQ 

« Hide

References

[1]"The complete mitochondrial genome of Yarrowia lipolytica."
Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.
Comp. Funct. Genomics 2:80-90(2001)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ307410 Genomic DNA. Translation: CAC28105.1.
RefSeqNP_075438.2. NC_002659.1.

3D structure databases

ProteinModelPortalQ9B6D5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q9B6D5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID802608.
KEGGyli:YalifMp18.

Phylogenomic databases

HOGENOMHOG000264988.
KOK02261.
OrthoDBEOG7WDNDC.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_YARLI
AccessionPrimary (citable) accession number: Q9B6D5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families