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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi177Copper ABy similarity1
Metal bindingi212Copper ABy similarity1
Metal bindingi216Copper ABy similarity1
Metal bindingi220Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini7 – 33Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei34 – 55HelicalSequence analysisAdd BLAST22
Topological domaini56 – 73Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei74 – 98HelicalSequence analysisAdd BLAST25
Topological domaini99 – 242Mitochondrial intermembraneSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000060471 – 242Cytochrome c oxidase subunit 2Add BLAST242

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Proteomic databases

PRIDEiQ9B6D5

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Protein-protein interaction databases

STRINGi4952.NP_075438.2

Structurei

3D structure databases

ProteinModelPortaliQ9B6D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988
InParanoidiQ9B6D5
KOiK02261
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9B6D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKIFNDVPV PYGLYFQDSA TPTFDGIIEL HDIVMFYIVV TIVLVSYLLF
60 70 80 90 100
VIIKNFSNDH ISYKYLTHGT TLEIVWTIFP VVILLFIAFP SFILLYLCDE
110 120 130 140 150
VIDPAMTIKA IASQWYWTYE YSDFIGETGE IVQFDSYIVP TDMLENGQLR
160 170 180 190 200
MLDVDARIVV PTNTHLRFIV TSRDVIHDFA LPSLGIKCDA TPGRLNQVSA
210 220 230 240
LLQRESVYYG QCSELCGVLH SSMPIALEAV SIDKFLSWLD EQ
Length:242
Mass (Da):27,636
Last modified:June 1, 2001 - v1
Checksum:i25A39C49A9262357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA Translation: CAC28105.1
RefSeqiNP_075438.2, NC_002659.1

Genome annotation databases

GeneIDi802608
KEGGiyli:YalifMp18

Similar proteinsi

Entry informationi

Entry nameiCOX2_YARLI
AccessioniPrimary (citable) accession number: Q9B6D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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