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Q9B6D5

- COX2_YARLI

UniProt

Q9B6D5 - COX2_YARLI

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi177 – 1771Copper ABy similarity
Metal bindingi212 – 2121Copper ABy similarity
Metal bindingi216 – 2161Copper ABy similarity
Metal bindingi220 – 2201Copper ABy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Mitochondrion

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Cytochrome c oxidase subunit 2PRO_0000006047Add
BLAST

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Protein-protein interaction databases

STRINGi4952.Q9B6D5.

Structurei

3D structure databases

ProteinModelPortaliQ9B6D5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini7 – 3327Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini56 – 7318Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini99 – 242144Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5522HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9825HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiQ9B6D5.
KOiK02261.
OrthoDBiEOG7WDNDC.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B6D5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKIFNDVPV PYGLYFQDSA TPTFDGIIEL HDIVMFYIVV TIVLVSYLLF
60 70 80 90 100
VIIKNFSNDH ISYKYLTHGT TLEIVWTIFP VVILLFIAFP SFILLYLCDE
110 120 130 140 150
VIDPAMTIKA IASQWYWTYE YSDFIGETGE IVQFDSYIVP TDMLENGQLR
160 170 180 190 200
MLDVDARIVV PTNTHLRFIV TSRDVIHDFA LPSLGIKCDA TPGRLNQVSA
210 220 230 240
LLQRESVYYG QCSELCGVLH SSMPIALEAV SIDKFLSWLD EQ
Length:242
Mass (Da):27,636
Last modified:June 1, 2001 - v1
Checksum:i25A39C49A9262357
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ307410 Genomic DNA. Translation: CAC28105.1.
RefSeqiNP_075438.2. NC_002659.1.

Genome annotation databases

GeneIDi802608.
KEGGiyli:YalifMp18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ307410 Genomic DNA. Translation: CAC28105.1 .
RefSeqi NP_075438.2. NC_002659.1.

3D structure databases

ProteinModelPortali Q9B6D5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q9B6D5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 802608.
KEGGi yli:YalifMp18.

Phylogenomic databases

HOGENOMi HOG000264988.
InParanoidi Q9B6D5.
KOi K02261.
OrthoDBi EOG7WDNDC.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial genome of Yarrowia lipolytica."
    Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.
    Comp. Funct. Genomics 2:80-90(2001)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.

Entry informationi

Entry nameiCOX2_YARLI
AccessioniPrimary (citable) accession number: Q9B6D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3