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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi177 – 1771Copper ABy similarity
Metal bindingi212 – 2121Copper ABy similarity
Metal bindingi216 – 2161Copper ABy similarity
Metal bindingi220 – 2201Copper ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini7 – 3327Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei34 – 5522HelicalSequence AnalysisAdd
BLAST
Topological domaini56 – 7318Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei74 – 9825HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 242144Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Cytochrome c oxidase subunit 2PRO_0000006047Add
BLAST

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Protein-protein interaction databases

STRINGi4952.NP_075438.2.

Structurei

3D structure databases

ProteinModelPortaliQ9B6D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiQ9B6D5.
KOiK02261.
OrthoDBiEOG7WDNDC.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B6D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKIFNDVPV PYGLYFQDSA TPTFDGIIEL HDIVMFYIVV TIVLVSYLLF
60 70 80 90 100
VIIKNFSNDH ISYKYLTHGT TLEIVWTIFP VVILLFIAFP SFILLYLCDE
110 120 130 140 150
VIDPAMTIKA IASQWYWTYE YSDFIGETGE IVQFDSYIVP TDMLENGQLR
160 170 180 190 200
MLDVDARIVV PTNTHLRFIV TSRDVIHDFA LPSLGIKCDA TPGRLNQVSA
210 220 230 240
LLQRESVYYG QCSELCGVLH SSMPIALEAV SIDKFLSWLD EQ
Length:242
Mass (Da):27,636
Last modified:June 1, 2001 - v1
Checksum:i25A39C49A9262357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA. Translation: CAC28105.1.
RefSeqiNP_075438.2. NC_002659.1.

Genome annotation databases

GeneIDi802608.
KEGGiyli:YalifMp18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ307410 Genomic DNA. Translation: CAC28105.1.
RefSeqiNP_075438.2. NC_002659.1.

3D structure databases

ProteinModelPortaliQ9B6D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.NP_075438.2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi802608.
KEGGiyli:YalifMp18.

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiQ9B6D5.
KOiK02261.
OrthoDBiEOG7WDNDC.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete mitochondrial genome of Yarrowia lipolytica."
    Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.
    Comp. Funct. Genomics 2:80-90(2001)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.

Entry informationi

Entry nameiCOX2_YARLI
AccessioniPrimary (citable) accession number: Q9B6D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.