true2004-08-162023-02-2289COX1_CHRKNConvergent evolution of cucurbitacin feeding in spatially isolated rootworm taxa (Coleoptera: Chrysomelidae; Galerucinae, Luperini).Gillespie J.J.Kjer K.M.Duckett C.N.Tallamy D.W.doi:10.1016/s1055-7903(03)00256-22003Mol. Phylogenet. Evol.29161-175NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-154Isolate JJG237Feeding specialization and host-derived chemical defense in Chrysomeline leaf beetles did not lead to an evolutionary dead end.Termonia A.Hsiao T.H.Pasteels J.M.Milinkovitch M.C.doi:10.1073/pnas.0610345982001Proc. Natl. Acad. Sci. U.S.A.983909-3914NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-219Cytochrome c oxidase-like, subunit I domainCyt_c_oxase-like_su1_domCyt_c_oxase-like_su1_sfCyt_C_Oxase_1Cyt_c_Oxase_su1_BSCYTOCHROME C OXIDASE SUBUNIT 1CYTOCHROME C OXIDASE SUBUNIT 1COX1CYCOXIDASEICytochrome c oxidase subunit I-likeCOX1COX1_CUBCytochrome c oxidase subunit 17.1.1.9Cytochrome c oxidase polypeptide ICOIComponent of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.Binds 2 heme A groups non-covalently per subunit.Binds a copper B center.Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).Belongs to the heme-copper respiratory oxidase family.Cytochrome c oxidase subunit 1240211219Mitochondrial matrixHelical; Name=III224Mitochondrial intermembrane2547Helical; Name=IV4877Mitochondrial matrix7889Helical; Name=V90119Mitochondrial intermembrane120134Helical; Name=VI135168Mitochondrial matrix169176Helical; Name=VII177193Mitochondrial intermembrane194205Helical; Name=VIII2061471511971981'-histidyl-3'-tyrosine (His-Tyr)L20ANTAHS4146EGMNFEQT8188L96B2004-08-162single240219173a0ca5493c561e17cd7bc6c13e1e2FPRMNNMSFWLLPPSLFLLIMSSIVENGAGTGWTVYPPLSSNIAHGGSSVDLAIFSLHLAGISSILGAINFITTVINMRPMGMKLDRMPLFVWAVVITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESSKKEVFGTLGMIYAMMAIGLLGFIVWAHHMFTVGMDVDTQTYFTSATMIItruetruetruetruetruetruetruetrue