Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Chrysomela knabi (Leaf beetle)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi147Copper BBy similarityCurated1
Metal bindingi151Copper BBy similarityCurated1
Metal bindingi197Copper BBy similarityCurated1
Metal bindingi198Copper BBy similarityCurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiChrysomela knabi (Leaf beetle)
Taxonomic identifieri153783 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaChrysomeloideaChrysomelidaeChrysomelinaeChrysomeliniChrysomela

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1Mitochondrial matrixBy similarity›1
Transmembranei2 – 24Helical; Name=IIIBy similarityAdd BLAST23
Topological domaini25 – 47Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei48 – 77Helical; Name=IVBy similarityAdd BLAST30
Topological domaini78 – 89Mitochondrial matrixBy similarityAdd BLAST12
Transmembranei90 – 119Helical; Name=VBy similarityAdd BLAST30
Topological domaini120 – 134Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei135 – 168Helical; Name=VIBy similarityAdd BLAST34
Topological domaini169 – 176Mitochondrial matrixBy similarity8
Transmembranei177 – 193Helical; Name=VIIBy similarityAdd BLAST17
Topological domaini194 – 205Mitochondrial intermembraneBy similarityAdd BLAST12
Transmembranei206 – ›219Helical; Name=VIIIBy similarityAdd BLAST›14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183314‹1 – ›219Cytochrome c oxidase subunit 1Add BLAST›219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki147 ↔ 1511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9B229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9B229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FPRMNNMSFW LLPPSLFLLI MSSIVENGAG TGWTVYPPLS SNIAHGGSSV
60 70 80 90 100
DLAIFSLHLA GISSILGAIN FITTVINMRP MGMKLDRMPL FVWAVVITAI
110 120 130 140 150
LLLLSLPVLA GAITMLLTDR NLNTSFFDPA GGGDPILYQH LFWFFGHPEV
160 170 180 190 200
YILILPGFGM ISHIISQESS KKEVFGTLGM IYAMMAIGLL GFIVWAHHMF
210
TVGMDVDTQT YFTSATMII
Length:219
Mass (Da):24,021
Last modified:August 16, 2004 - v2
Checksum:i93BD81BF4358C92D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Sequence conflicti20I → L in AAK16643 (PubMed:11259651).Curated1
Sequence conflicti41 – 46SNIAHG → ANTAHS in AAK16643 (PubMed:11259651).Curated6
Sequence conflicti81 – 88MGMKLDRM → EGMNFEQT in AAK16643 (PubMed:11259651).Curated8
Sequence conflicti96V → L in AAK16643 (PubMed:11259651).Curated1
Non-terminal residuei219Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY242402 Genomic DNA. Translation: AAP13120.1.
AY027627 Genomic DNA. Translation: AAK16643.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY242402 Genomic DNA. Translation: AAP13120.1.
AY027627 Genomic DNA. Translation: AAK16643.1.

3D structure databases

ProteinModelPortaliQ9B229.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_CHRKN
AccessioniPrimary (citable) accession number: Q9B229
Secondary accession number(s): Q85KD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.