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Q9B229

- COX1_CHRKN

UniProt

Q9B229 - COX1_CHRKN

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Chrysomela knabi (Leaf beetle)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi147 – 1471Copper B InferredBy similarity
Metal bindingi151 – 1511Copper B InferredBy similarity
Metal bindingi197 – 1971Copper B InferredBy similarity
Metal bindingi198 – 1981Copper B InferredBy similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiChrysomela knabi (Leaf beetle)
Taxonomic identifieri153783 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaChrysomeloideaChrysomelidaeChrysomelinaeChrysomeliniChrysomela

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1›1Mitochondrial matrix By similarityBy similarity
Transmembranei2 – 2423Helical; Name=III; By similarityBy similarity
Add
BLAST
Topological domaini25 – 4723Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei48 – 7730Helical; Name=IV; By similarityBy similarity
Add
BLAST
Topological domaini78 – 8912Mitochondrial matrix By similarityBy similarity
Add
BLAST
Transmembranei90 – 11930Helical; Name=V; By similarityBy similarity
Add
BLAST
Topological domaini120 – 13415Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei135 – 16834Helical; Name=VI; By similarityBy similarity
Add
BLAST
Topological domaini169 – 1768Mitochondrial matrix By similarityBy similarity
Transmembranei177 – 19317Helical; Name=VII; By similarityBy similarity
Add
BLAST
Topological domaini194 – 20512Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei206 – ›219›14Helical; Name=VIII; By similarityBy similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›219›219Cytochrome c oxidase subunit 1
PRO_0000183314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki147 ↔ 1511'-histidyl-3'-tyrosine (His-Tyr) By similarityBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ9B229.
SMRiQ9B229. Positions 1-219.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9B229-1 [UniParc]FASTAAdd to Basket

« Hide

FPRMNNMSFW LLPPSLFLLI MSSIVENGAG TGWTVYPPLS SNIAHGGSSV    50
DLAIFSLHLA GISSILGAIN FITTVINMRP MGMKLDRMPL FVWAVVITAI 100
LLLLSLPVLA GAITMLLTDR NLNTSFFDPA GGGDPILYQH LFWFFGHPEV 150
YILILPGFGM ISHIISQESS KKEVFGTLGM IYAMMAIGLL GFIVWAHHMF 200
TVGMDVDTQT YFTSATMII 219
Length:219
Mass (Da):24,021
Last modified:August 16, 2004 - v2
Checksum:i93BD81BF4358C92D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201I → L in AAK16643. 1 Publication
Sequence conflicti41 – 466SNIAHG → ANTAHS in AAK16643. 1 Publication
Sequence conflicti81 – 888MGMKLDRM → EGMNFEQT in AAK16643. 1 Publication
Sequence conflicti96 – 961V → L in AAK16643. 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei219 – 2191

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY242402 Genomic DNA. Translation: AAP13120.1.
AY027627 Genomic DNA. Translation: AAK16643.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY242402 Genomic DNA. Translation: AAP13120.1 .
AY027627 Genomic DNA. Translation: AAK16643.1 .

3D structure databases

ProteinModelPortali Q9B229.
SMRi Q9B229. Positions 1-219.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Convergent evolution of cucurbitacin feeding in spatially isolated rootworm taxa (Coleoptera: Chrysomelidae; Galerucinae, Luperini)."
    Gillespie J.J., Kjer K.M., Duckett C.N., Tallamy D.W.
    Mol. Phylogenet. Evol. 29:161-175(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-154.
    Strain: Isolate JJG237.
  2. "Feeding specialization and host-derived chemical defense in Chrysomeline leaf beetles did not lead to an evolutionary dead end."
    Termonia A., Hsiao T.H., Pasteels J.M., Milinkovitch M.C.
    Proc. Natl. Acad. Sci. U.S.A. 98:3909-3914(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-219.

Entry informationi

Entry nameiCOX1_CHRKN
AccessioniPrimary (citable) accession number: Q9B229
Secondary accession number(s): Q85KD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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