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Q9B229

- COX1_CHRKN

UniProt

Q9B229 - COX1_CHRKN

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Chrysomela knabi (Leaf beetle)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi147 – 1471Copper BBy similarityCurated
Metal bindingi151 – 1511Copper BBy similarityCurated
Metal bindingi197 – 1971Copper BBy similarityCurated
Metal bindingi198 – 1981Copper BBy similarityCurated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiChrysomela knabi (Leaf beetle)
Taxonomic identifieri153783 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaChrysomeloideaChrysomelidaeChrysomelinaeChrysomeliniChrysomela

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›219›219Cytochrome c oxidase subunit 1PRO_0000183314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki147 ↔ 1511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9B229.
SMRiQ9B229. Positions 1-219.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1›1Mitochondrial matrixBy similarity
Topological domaini25 – 4723Mitochondrial intermembraneBy similarityAdd
BLAST
Topological domaini78 – 8912Mitochondrial matrixBy similarityAdd
BLAST
Topological domaini120 – 13415Mitochondrial intermembraneBy similarityAdd
BLAST
Topological domaini169 – 1768Mitochondrial matrixBy similarity
Topological domaini194 – 20512Mitochondrial intermembraneBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2423Helical; Name=IIIBy similarityAdd
BLAST
Transmembranei48 – 7730Helical; Name=IVBy similarityAdd
BLAST
Transmembranei90 – 11930Helical; Name=VBy similarityAdd
BLAST
Transmembranei135 – 16834Helical; Name=VIBy similarityAdd
BLAST
Transmembranei177 – 19317Helical; Name=VIIBy similarityAdd
BLAST
Transmembranei206 – ›219›14Helical; Name=VIIIBy similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9B229-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
FPRMNNMSFW LLPPSLFLLI MSSIVENGAG TGWTVYPPLS SNIAHGGSSV
60 70 80 90 100
DLAIFSLHLA GISSILGAIN FITTVINMRP MGMKLDRMPL FVWAVVITAI
110 120 130 140 150
LLLLSLPVLA GAITMLLTDR NLNTSFFDPA GGGDPILYQH LFWFFGHPEV
160 170 180 190 200
YILILPGFGM ISHIISQESS KKEVFGTLGM IYAMMAIGLL GFIVWAHHMF
210
TVGMDVDTQT YFTSATMII
Length:219
Mass (Da):24,021
Last modified:August 16, 2004 - v2
Checksum:i93BD81BF4358C92D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Sequence conflicti20 – 201I → L in AAK16643. (PubMed:11259651)Curated
Sequence conflicti41 – 466SNIAHG → ANTAHS in AAK16643. (PubMed:11259651)Curated
Sequence conflicti81 – 888MGMKLDRM → EGMNFEQT in AAK16643. (PubMed:11259651)Curated
Sequence conflicti96 – 961V → L in AAK16643. (PubMed:11259651)Curated
Non-terminal residuei219 – 2191Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY242402 Genomic DNA. Translation: AAP13120.1.
AY027627 Genomic DNA. Translation: AAK16643.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY242402 Genomic DNA. Translation: AAP13120.1 .
AY027627 Genomic DNA. Translation: AAK16643.1 .

3D structure databases

ProteinModelPortali Q9B229.
SMRi Q9B229. Positions 1-219.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Convergent evolution of cucurbitacin feeding in spatially isolated rootworm taxa (Coleoptera: Chrysomelidae; Galerucinae, Luperini)."
    Gillespie J.J., Kjer K.M., Duckett C.N., Tallamy D.W.
    Mol. Phylogenet. Evol. 29:161-175(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-154.
    Strain: Isolate JJG2371 Publication.
  2. "Feeding specialization and host-derived chemical defense in Chrysomeline leaf beetles did not lead to an evolutionary dead end."
    Termonia A., Hsiao T.H., Pasteels J.M., Milinkovitch M.C.
    Proc. Natl. Acad. Sci. U.S.A. 98:3909-3914(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-219.

Entry informationi

Entry nameiCOX1_CHRKN
AccessioniPrimary (citable) accession number: Q9B229
Secondary accession number(s): Q85KD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3