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Protein

Cytochrome c oxidase subunit 3

Gene

COX3A

more
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: CGD

GO - Biological processi

  • aerobic electron transport chain Source: InterPro
  • mitochondrial electron transport, cytochrome c to oxygen Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3A
ORF Names:CaalfMp04
AND
Name:COX3B
ORF Names:CaalfMp15
Encoded oniMitochondrion
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Mitochondrion

Organism-specific databases

CGDiCAL0000183335. COX3A.
CAL0000191504. COX3B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003568701 – 269Cytochrome c oxidase subunit 3Add BLAST269

Proteomic databases

PRIDEiQ9B1P9.

Structurei

3D structure databases

ProteinModelPortaliQ9B1P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264954.
InParanoidiQ9B1P9.
KOiK02262.
OrthoDBiEOG092C4IN0.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B1P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNVRGYLQ LHPFHLVGPS PWPIFTSFSL MDLALSLGLT AHGYIASIWP
60 70 80 90 100
IFLAIIAVLY SMTLWFKDII AESTYLGDHT LAVKRGLNQG FLLFVVSEIL
110 120 130 140 150
IFASLFWAYL HSALNPTMDL GMQWPPVGIP TISPAELPLL NTIILLASGV
160 170 180 190 200
TVTYAHHALI NGNRTNTLYG FTYTTILIAL FVYFQYLEYS YAGFTLSDGV
210 220 230 240 250
YGSTFFSLTG LHGLHMIMLT IMLMICTWRV YNYDFTNTSH VGAETTILYL
260
HVLDVIWLFI YIIVYWWGS
Length:269
Mass (Da):30,422
Last modified:July 5, 2004 - v2
Checksum:i270DFCE987B010C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA. Translation: AAG59590.2.
AF285261 Genomic DNA. Translation: AAG59599.2.
RefSeqiNP_075033.2. NC_002653.1.
NP_075042.2. NC_002653.1.

Genome annotation databases

GeneIDi802550.
802563.
KEGGical:CaalfMp04.
cal:CaalfMp15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA. Translation: AAG59590.2.
AF285261 Genomic DNA. Translation: AAG59599.2.
RefSeqiNP_075033.2. NC_002653.1.
NP_075042.2. NC_002653.1.

3D structure databases

ProteinModelPortaliQ9B1P9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9B1P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi802550.
802563.
KEGGical:CaalfMp04.
cal:CaalfMp15.

Organism-specific databases

CGDiCAL0000183335. COX3A.
CAL0000191504. COX3B.

Phylogenomic databases

HOGENOMiHOG000264954.
InParanoidiQ9B1P9.
KOiK02262.
OrthoDBiEOG092C4IN0.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_CANAL
AccessioniPrimary (citable) accession number: Q9B1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.