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Protein

Cytochrome c oxidase subunit 3

Gene

COX3A

more
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: CGD

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3A
ORF Names:CaalfMp04
AND
Name:COX3B
ORF Names:CaalfMp15
Encoded oniMitochondrion
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Mitochondrion

Organism-specific databases

CGDiCAF0007363. COX3A.
CAF0007403. COX3B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000356870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAF0007363.

Structurei

3D structure databases

ProteinModelPortaliQ9B1P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
InParanoidiQ9B1P9.
KOiK02262.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B1P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNVRGYLQ LHPFHLVGPS PWPIFTSFSL MDLALSLGLT AHGYIASIWP
60 70 80 90 100
IFLAIIAVLY SMTLWFKDII AESTYLGDHT LAVKRGLNQG FLLFVVSEIL
110 120 130 140 150
IFASLFWAYL HSALNPTMDL GMQWPPVGIP TISPAELPLL NTIILLASGV
160 170 180 190 200
TVTYAHHALI NGNRTNTLYG FTYTTILIAL FVYFQYLEYS YAGFTLSDGV
210 220 230 240 250
YGSTFFSLTG LHGLHMIMLT IMLMICTWRV YNYDFTNTSH VGAETTILYL
260
HVLDVIWLFI YIIVYWWGS
Length:269
Mass (Da):30,422
Last modified:July 5, 2004 - v2
Checksum:i270DFCE987B010C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA. Translation: AAG59590.2.
AF285261 Genomic DNA. Translation: AAG59599.2.
RefSeqiNP_075033.2. NC_002653.1.
NP_075042.2. NC_002653.1.

Genome annotation databases

GeneIDi802550.
802563.
KEGGical:CaalfMp04.
cal:CaalfMp15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285261 Genomic DNA. Translation: AAG59590.2.
AF285261 Genomic DNA. Translation: AAG59599.2.
RefSeqiNP_075033.2. NC_002653.1.
NP_075042.2. NC_002653.1.

3D structure databases

ProteinModelPortaliQ9B1P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAF0007363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi802550.
802563.
KEGGical:CaalfMp04.
cal:CaalfMp15.

Organism-specific databases

CGDiCAF0007363. COX3A.
CAF0007403. COX3B.

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
InParanoidiQ9B1P9.
KOiK02262.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans."
    Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M.
    J. Bacteriol. 183:865-872(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCOX3_CANAL
AccessioniPrimary (citable) accession number: Q9B1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.