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Q9B1P9

- COX3_CANAL

UniProt

Q9B1P9 - COX3_CANAL

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Protein

Cytochrome c oxidase subunit 3

Gene
COX3A, CaalfMp04
COX3B, CaalfMp15
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: CGD

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3A
ORF Names:CaalfMp04
AND
Name:COX3B
ORF Names:CaalfMp15
Encoded oniMitochondrion
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Mitochondrion
CGDiCAF0007363. COX3A.
CAF0007403. COX3B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: CGD

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000356870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAF0007363.

Structurei

3D structure databases

ProteinModelPortaliQ9B1P9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
KOiK02262.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9B1P9-1 [UniParc]FASTAAdd to Basket

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MTNNVRGYLQ LHPFHLVGPS PWPIFTSFSL MDLALSLGLT AHGYIASIWP    50
IFLAIIAVLY SMTLWFKDII AESTYLGDHT LAVKRGLNQG FLLFVVSEIL 100
IFASLFWAYL HSALNPTMDL GMQWPPVGIP TISPAELPLL NTIILLASGV 150
TVTYAHHALI NGNRTNTLYG FTYTTILIAL FVYFQYLEYS YAGFTLSDGV 200
YGSTFFSLTG LHGLHMIMLT IMLMICTWRV YNYDFTNTSH VGAETTILYL 250
HVLDVIWLFI YIIVYWWGS 269
Length:269
Mass (Da):30,422
Last modified:July 5, 2004 - v2
Checksum:i270DFCE987B010C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285261 Genomic DNA. Translation: AAG59590.2.
AF285261 Genomic DNA. Translation: AAG59599.2.
RefSeqiNP_075033.2. NC_002653.1.
NP_075042.2. NC_002653.1.

Genome annotation databases

GeneIDi802550.
802563.
KEGGical:CaalfMp04.
cal:CaalfMp15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285261 Genomic DNA. Translation: AAG59590.2 .
AF285261 Genomic DNA. Translation: AAG59599.2 .
RefSeqi NP_075033.2. NC_002653.1.
NP_075042.2. NC_002653.1.

3D structure databases

ProteinModelPortali Q9B1P9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAF0007363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 802550.
802563.
KEGGi cal:CaalfMp04.
cal:CaalfMp15.

Organism-specific databases

CGDi CAF0007363. COX3A.
CAF0007403. COX3B.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000264954.
KOi K02262.
OrthoDBi EOG7V76HP.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans."
    Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T., Kohn L.M.
    J. Bacteriol. 183:865-872(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCOX3_CANAL
AccessioniPrimary (citable) accession number: Q9B1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi