ID   Q9B1M0_HUMAN            Unreviewed;       603 AA.
AC   Q9B1M0;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|ARBA:ARBA00021096, ECO:0000256|RuleBase:RU003404};
DE            EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003404};
GN   Name=ND5 {ECO:0000313|EMBL:ABB78829.1};
OS   Homo sapiens (Human).
OG   Mitochondrion {ECO:0000313|EMBL:AAK17893.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAK17893.1};
RN   [1] {ECO:0000313|EMBL:AAK17893.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11130070; DOI=10.1038/35047064;
RA   Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [2] {ECO:0000313|EMBL:AAK17893.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ABJ99108.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1_U6a {ECO:0000313|EMBL:ABJ99108.1};
RX   PubMed=17170302; DOI=10.1126/science.1135566;
RA   Olivieri A., Achilli A., pala M., Battaglia V., Fornarino S., Al-Zahery N.,
RA   Scozzari R., Cruciani F., Behar D.M., Dugoujon J.-M., Coudray C.,
RA   Santachiara-Benerecetti A.S., Semino O., Bandelt H.-J., Torroni A.;
RT   "The mtDNA legacy of the Levantine early Upper Palaeolithic in Africa.";
RL   Science 314:1767-1770(2006).
RN   [4] {ECO:0000313|EMBL:ABB78829.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B2-2-03 {ECO:0000313|EMBL:ABB78829.1};
RX   PubMed=19083815;
RA   Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J.;
RT   "Complete mitochondrial genome sequences for 265 African American and U.S.
RT   "Hispanic" individuals.";
RL   Forensic Sci. Int. Genet. 2:e45-e48(2008).
RN   [5] {ECO:0000313|EMBL:ADB78170.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LHON family 370 {ECO:0000313|EMBL:ADB78170.1};
RX   PubMed=20643099; DOI=10.1016/j.bbrc.2010.07.051;
RA   Zou Y., Jia X., Zhang A.M., Wang W.Z., Li S., Guo X., Kong Q.P., Zhang Q.,
RA   Yao Y.G.;
RT   "The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families
RT   with clinical features of LHON but lacking the three primary mutations.";
RL   Biochem. Biophys. Res. Commun. 399:179-185(2010).
RN   [6] {ECO:0000313|EMBL:ADU77831.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21176127; DOI=10.1186/1471-2148-10-390;
RA   Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B.,
RA   Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., Macaulay V.;
RT   "Population expansion in the North African late Pleistocene signalled by
RT   mitochondrial DNA haplogroup U6.";
RL   BMC Evol. Biol. 10:390-390(2010).
RN   [7] {ECO:0000313|EMBL:ADB78170.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LHON family 370 {ECO:0000313|EMBL:ADB78170.1};
RA   Zou Y., Zhang A.-M., Yao Y.-G.;
RT   "The mitochondrial ND1 and ND5 genes are mutational hotspots for Chinese
RT   families with clinical features of Leber hereditary optic neuropathy but
RT   without the three primary mutations.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ADD53392.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pradutkanchana S., Ishida T., Kimura R.;
RT   "Mitochondrial diversity of the sea nomads of Thailand.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:ADE33595.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kong Q.-P., Sun C., Wang H.-W., Zhao M., Wang W.-Z., Zhong L., Hao X.-D.,
RA   Pan H., Wang S.-Y., Cheng Y.-T., Zhu C.-L., Wu S.-F., Liu L.-N., Jin J.-Q.,
RA   Yao Y.-G., Zhang Y.-P.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:ADE33595.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20713468; DOI=10.1093/molbev/msq219;
RA   Kong Q.P., Sun C., Wang H.W., Zhao M., Wang W.Z., Zhong L., Hao X.D.,
RA   Pan H., Wang S.Y., Cheng Y.T., Zhu C.L., Wu S.F., Liu L.N., Jin J.Q.,
RA   Yao Y.G., Zhang Y.P.;
RT   "Large-scale mtDNA screening reveals a surprising matrilineal complexity in
RT   east Asia and its implications to the peopling of the region.";
RL   Mol. Biol. Evol. 28:513-522(2011).
RN   [11] {ECO:0000313|EMBL:AFG04229.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22482806; DOI=10.1016/j.ajhg.2012.03.002;
RA   Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M.,
RA   Kivisild T., Torroni A., Villems R.;
RT   "A "Copernican" reassessment of the human mitochondrial DNA tree from its
RT   root.";
RL   Am. J. Hum. Genet. 90:675-684(2012).
RN   [12] {ECO:0000313|EMBL:AGX91484.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Loo J.-H., Trejaut J.A., Yen J.-C., Chen Z.-S., Ng W.-M., Huang C.-Y.,
RA   Hsu K.-N., Hung K.-H., Hsiao Y., Wei Y.-H., Lin M.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AGX91484.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24713204; DOI=10.1186/1756-0500-7-223;
RA   Loo J.H., Trejaut J.A., Yen J.C., Chen Z.S., Ng W.M., Huang C.Y., Hsu K.N.,
RA   Hung K.H., Hsiao Y., Wei Y.H., Lin M.;
RT   "Mitochondrial DNA association study of type 2 diabetes with or without
RT   ischemic stroke in Taiwan.";
RL   BMC Res. Notes 7:223-223(2014).
RN   [14] {ECO:0000313|EMBL:AMZ82329.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kloss-Brandstaetter A.;
RT   "mitochondrial Population structure in Cambodia.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:APD53020.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27837350;
RA   Kutanan W., Kampuansai J., Srikummool M., Kangwanpong D., Ghirotto S.,
RA   Brunelli A., Stoneking M.;
RT   "Complete mitochondrial genomes of Thai and Lao populations indicate an
RT   ancient origin of Austroasiatic groups and demic diffusion in the spread of
RT   Tai-Kadai languages.";
RL   Hum. Genet. 0:0-0(2016).
RN   [16] {ECO:0000313|EMBL:ANP95281.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27343181; DOI=10.1007/s12035-016-9996-x;
RA   Li H., Bi R., Fan Y., Wu Y., Tang Y., Li Z., He Y., Zhou J., Tang J.,
RA   Chen X., Yao Y.G.;
RT   "mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia.";
RL   Mol. Neurobiol. 54:4343-4352(2017).
RN   [17] {ECO:0000313|EMBL:ARD72421.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28287095; DOI=.1038/srep43041;
RA   Nagle N., van Oven M., Wilcox S., van Holst Pellekaan S., Tyler-Smith C.,
RA   Xue Y., Ballantyne K.N., Wilcox L., Papac L., Cooke K., van Oorschot R.A.,
RA   McAllister P., Williams L., Kayser M., Mitchell R.J.;
RT   "Aboriginal Australian mitochondrial genome variation - an increased
RT   understanding of population antiquity and diversity.";
RL   Sci. Rep. 7:43041-43041(2017).
RN   [18] {ECO:0000313|EMBL:AVL84996.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29483671; DOI=10.1038/s41431-018-0113-7;
RA   Kutanan W., Kampuansai J., Brunelli A., Ghirotto S., Pittayaporn P.,
RA   Ruangchai S., Schroder R., Macholdt E., Srikummool M., Kangwanpong D.,
RA   Hubner A., Arias L., Stoneking M.;
RT   "New insights from Thailand into the maternal genetic history of Mainland
RT   Southeast Asia.";
RL   Eur. J. Hum. Genet. 26:898-911(2018).
RN   [19] {ECO:0000313|EMBL:AYW04111.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30076323; DOI=10.1038/s41598-018-29989-0;
RA   Duong N.T., Macholdt E., Ton N.D., Arias L., Schroder R., Van Phong N.,
RA   Thi Bich Thuy V., Ha N.H., Thi Thu Hue H., Thi Xuan N., Thi Phuong Oanh K.,
RA   Hien L.T., Hoang N.H., Pakendorf B., Stoneking M., Van Hai N.;
RT   "Complete human mtDNA genome sequences from Vietnam and the phylogeography
RT   of Mainland Southeast Asia.";
RL   Sci. Rep. 8:11651-11651(2018).
RN   [20] {ECO:0000313|EMBL:AYW04111.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nong H.V.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:QBB87844.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Brucato N., Fernandes V., Kusuma P., Cerny V., Mulligan C.J., Soares P.,
RA   Rito T., Besse C., Boland A., Deleuze J.-F., Cox M.P., Sudoyo H.,
RA   Stoneking M., Pereira L., Ricaut F.-X.;
RT   "Evidence of Austronesian genetic lineages in East Africa and South Arabia:
RT   complex dispersal from Madagascar and Southeast Asia.";
RL   Genome Biol. Evol. 0:0-0(2019).
RN   [22] {ECO:0000313|EMBL:QIQ23293.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood Serum {ECO:0000313|EMBL:QIQ23293.1};
RX   PubMed=32150286;
RA   Li M., DeRosa K.L., Mann H., Spathis R., Roome A., Castellanos D.,
RA   Gowen K., de Smet T.S., Echard J., Casey K., Shamoon-Pour M., Garruto R.M.,
RA   Lum K.;
RT   "Recent kuru-induced female gene flow disrupted the coevolution of genes
RT   and languages in the Papua New Guinea highlands.";
RL   Am. J. Phys. Anthropol. 0:0-0(2020).
RN   [23] {ECO:0000313|EMBL:QMP91258.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HM108 {ECO:0000313|EMBL:QMP91258.1}, HM126
RC   {ECO:0000313|EMBL:QMP91362.1}, HM309 {ECO:0000313|EMBL:QMP91856.1},
RC   HM327 {ECO:0000313|EMBL:QMP92038.1}, HM451
RC   {ECO:0000313|EMBL:QMP92467.1}, HM452 {ECO:0000313|EMBL:QMP92480.1},
RC   HM453 {ECO:0000313|EMBL:QMP92493.1}, HM459
RC   {ECO:0000313|EMBL:QMP92532.1}, HMP114 {ECO:0000313|EMBL:QMP92779.1},
RC   PM138 {ECO:0000313|EMBL:QMP94677.1}, Y207
RC   {ECO:0000313|EMBL:QMP95704.1}, and Y236 {ECO:0000313|EMBL:QMP95860.1};
RX   PubMed=32690935; DOI=10.1038/s41431-020-0693-x;
RA   Kutanan W., Shoocongdej R., Srikummool M., Hubner A., Suttipai T.,
RA   Srithawong S., Kampuansai J., Stoneking M.;
RT   "Cultural variation impacts paternal and maternal genetic lineages of the
RT   Hmong-Mien and Sino-Tibetan groups from Thailand.";
RL   Eur. J. Hum. Genet. 28:1563-1579(2020).
RN   [24] {ECO:0000313|EMBL:QKT23019.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=32483274;
RA   Pedro N., Brucato N., Fernandes V., Andre M., Saag L., Pomat W., Besse C.,
RA   Boland A., Deleuze J.F., Clarkson C., Sudoyo H., Metspalu M., Stoneking M.,
RA   Cox M.P., Leavesley M., Pereira L., Ricaut F.X.;
RT   "Papuan mitochondrial genomes and the settlement of Sahul.";
RL   J. Hum. Genet. 0:0-0(2020).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000256|RuleBase:RU003404}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000766,
CC         ECO:0000256|RuleBase:RU003404};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000256|ARBA:ARBA00024376}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004448}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family.
CC       {ECO:0000256|RuleBase:RU003404}.
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DR   EMBL; AF347004; AAK17750.1; -; Genomic_DNA.
DR   EMBL; AF347015; AAK17893.1; -; Genomic_DNA.
DR   EMBL; DQ282443; ABB78829.1; -; Genomic_DNA.
DR   EMBL; EF064317; ABJ99108.1; -; Genomic_DNA.
DR   EMBL; GU377083; ADB78170.1; -; Genomic_DNA.
DR   EMBL; GU810031; ADD53392.1; -; Genomic_DNA.
DR   EMBL; GU810040; ADD53509.1; -; Genomic_DNA.
DR   EMBL; HM030539; ADE33595.1; -; Genomic_DNA.
DR   EMBL; HQ651702; ADU77831.1; -; Genomic_DNA.
DR   EMBL; JQ705097; AFG04229.1; -; Genomic_DNA.
DR   EMBL; KC252469; AGX91484.1; -; Genomic_DNA.
DR   EMBL; KT587502; AMZ82329.1; -; Genomic_DNA.
DR   EMBL; KX228179; ANP95281.1; -; Genomic_DNA.
DR   EMBL; KX228180; ANP95294.1; -; Genomic_DNA.
DR   EMBL; KX228181; ANP95307.1; -; Genomic_DNA.
DR   EMBL; KX456460; APD53020.1; -; Genomic_DNA.
DR   EMBL; KX456606; APD54918.1; -; Genomic_DNA.
DR   EMBL; KX456652; APD55516.1; -; Genomic_DNA.
DR   EMBL; KX457130; APD61729.1; -; Genomic_DNA.
DR   EMBL; KY595599; ARD72421.1; -; Genomic_DNA.
DR   EMBL; KY595662; ARD73240.1; -; Genomic_DNA.
DR   EMBL; MG272582; AVL84996.1; -; Genomic_DNA.
DR   EMBL; MG272956; AVL89858.1; -; Genomic_DNA.
DR   EMBL; MH448953; AYW04111.1; -; Genomic_DNA.
DR   EMBL; MH448962; AYW04228.1; -; Genomic_DNA.
DR   EMBL; MH449057; AYW05463.1; -; Genomic_DNA.
DR   EMBL; MH449063; AYW05541.1; -; Genomic_DNA.
DR   EMBL; MH449288; AYW08463.1; -; Genomic_DNA.
DR   EMBL; MH449289; AYW08476.1; -; Genomic_DNA.
DR   EMBL; MK128842; QBB87844.1; -; Genomic_DNA.
DR   EMBL; MN398672; QIQ23293.1; -; Genomic_DNA.
DR   EMBL; MN398681; QIQ23410.1; -; Genomic_DNA.
DR   EMBL; MN398693; QIQ23566.1; -; Genomic_DNA.
DR   EMBL; MN398694; QIQ23579.1; -; Genomic_DNA.
DR   EMBL; MN398695; QIQ23592.1; -; Genomic_DNA.
DR   EMBL; MN849575; QKT23019.1; -; Genomic_DNA.
DR   EMBL; MT418979; QMP91258.1; -; Genomic_DNA.
DR   EMBL; MT418987; QMP91362.1; -; Genomic_DNA.
DR   EMBL; MT419025; QMP91856.1; -; Genomic_DNA.
DR   EMBL; MT419039; QMP92038.1; -; Genomic_DNA.
DR   EMBL; MT419072; QMP92467.1; -; Genomic_DNA.
DR   EMBL; MT419073; QMP92480.1; -; Genomic_DNA.
DR   EMBL; MT419074; QMP92493.1; -; Genomic_DNA.
DR   EMBL; MT419077; QMP92532.1; -; Genomic_DNA.
DR   EMBL; MT419096; QMP92779.1; -; Genomic_DNA.
DR   EMBL; MT419242; QMP94677.1; -; Genomic_DNA.
DR   EMBL; MT419322; QMP95704.1; -; Genomic_DNA.
DR   EMBL; MT419334; QMP95860.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9B1M0; -.
DR   PeptideAtlas; Q9B1M0; -.
DR   ChiTaRS; MT-ND5; human.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   NCBIfam; TIGR01974; NDH_I_L; 1.
DR   PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR   PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   PRINTS; PR01434; NADHDHGNASE5.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003404};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU003404};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003404};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003404};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003404};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003404};
KW   Ubiquinone {ECO:0000256|RuleBase:RU003404}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..603
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010510544"
FT   TRANSMEM        84..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        117..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        172..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        211..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        245..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        272..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        301..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        368..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        406..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        454..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        484..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        584..602
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   DOMAIN          68..118
FT                   /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00662"
FT   DOMAIN          134..419
FT                   /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
FT   DOMAIN          422..602
FT                   /note="NADH dehydrogenase subunit 5 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06455"
SQ   SEQUENCE   603 AA;  67012 MW;  2CCFF1B9AFF638EB CRC64;
     MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP TTMFMCLDQE
     VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI MEFSLWYMNS DPNINQFFKY
     LLIFLITMLI LVTANNLFQL FIGWEGVGIM SFLLISWWYA RADANTAAIQ AVLYNRIGDI
     GFILALAWFI LHSNSWDPQQ MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP
     TPVSALLHSS TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK
     IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG
     GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN MSYTNAWALS ITLIATSLTS
     AYSTRMILLT LTGQPRFPTL TNINENNPTL LNPIKRLAAG SLFAGFLITN NISPASPFQT
     TIPLYLKLTA LAVTFLGLLT ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL
     GLLTSQNLPL LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL
     LIT
//