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Q9B1M0

- Q9B1M0_HUMAN

UniProt

Q9B1M0 - Q9B1M0_HUMAN

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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Electron transport, Respiratory chainSAAS annotation, Transport

Keywords - Ligandi

NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotationSAAS annotation)
Gene namesi
Name:ND5Imported
Encoded oniMitochondrionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ9B1M0.

Structurei

3D structure databases

ProteinModelPortaliQ9B1M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9B1M0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP
60 70 80 90 100
TTMFMCLDQE VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI
110 120 130 140 150
MEFSLWYMNS DPNINQFFKY LLIFLITMLI LVTANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLISWWYA RADANTAAIQ AVLYNRIGDI GFILALAWFI LHSNSWDPQQ
210 220 230 240 250
MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK
310 320 330 340 350
IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL
360 370 380 390 400
NNEQDIRKMG GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN
410 420 430 440 450
MSYTNAWALS ITLIATSLTS AYSTRMILLT LTGQPRFPTL TNINENNPTL
460 470 480 490 500
LNPIKRLAAG SLFAGFLITN NISPASPFQT TIPLYLKLTA LAVTFLGLLT
510 520 530 540 550
ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL GLLTSQNLPL
560 570 580 590 600
LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL

LIT
Length:603
Mass (Da):67,012
Last modified:June 1, 2001 - v1
Checksum:i2CCFF1B9AFF638EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF347004 Genomic DNA. Translation: AAK17750.1.
AF347015 Genomic DNA. Translation: AAK17893.1.
DQ282443 Genomic DNA. Translation: ABB78829.1.
EF064317 Genomic DNA. Translation: ABJ99108.1.
GU377083 Genomic DNA. Translation: ADB78170.1.
GU810031 Genomic DNA. Translation: ADD53392.1.
GU810040 Genomic DNA. Translation: ADD53509.1.
HM030539 Genomic DNA. Translation: ADE33595.1.
HQ651702 Genomic DNA. Translation: ADU77831.1.
JQ705097 Genomic DNA. Translation: AFG04229.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF347004 Genomic DNA. Translation: AAK17750.1 .
AF347015 Genomic DNA. Translation: AAK17893.1 .
DQ282443 Genomic DNA. Translation: ABB78829.1 .
EF064317 Genomic DNA. Translation: ABJ99108.1 .
GU377083 Genomic DNA. Translation: ADB78170.1 .
GU810031 Genomic DNA. Translation: ADD53392.1 .
GU810040 Genomic DNA. Translation: ADD53509.1 .
HM030539 Genomic DNA. Translation: ADE33595.1 .
HQ651702 Genomic DNA. Translation: ADU77831.1 .
JQ705097 Genomic DNA. Translation: AFG04229.1 .

3D structure databases

ProteinModelPortali Q9B1M0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9B1M0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108343.

Miscellaneous databases

NextBioi 35541626.

Family and domain databases

InterProi IPR010934. NADH_DH_su5_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
[Graphical view ]
Pfami PF06455. NADH5_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01974. NDH_I_L. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial genome variation and the origin of modern humans."
    Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
    Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Ingman M., Kaessmann H., Paabo S., Gyllensten U.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1_U6aImported.
  4. "Complete mitochondrial genome sequences for 265 African American and U.S. "Hispanic" individuals."
    Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J.
    Forensic Sci. Int. Genet. 2:e45-e48(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B2-2-03Imported.
  5. "The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations."
    Zou Y., Jia X., Zhang A.M., Wang W.Z., Li S., Guo X., Kong Q.P., Zhang Q., Yao Y.G.
    Biochem. Biophys. Res. Commun. 399:179-185(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LHON family 370Imported.
  6. "Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6."
    Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B., Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., Macaulay V.
    BMC Evol. Biol. 10:390-390(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "The mitochondrial ND1 and ND5 genes are mutational hotspots for Chinese families with clinical features of Leber hereditary optic neuropathy but without the three primary mutations."
    Zou Y., Zhang A.-M., Yao Y.-G.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LHON family 370Imported.
  8. "Mitochondrial diversity of the sea nomads of Thailand."
    Pradutkanchana S., Ishida T., Kimura R.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Cited for: NUCLEOTIDE SEQUENCE.
  10. "Large-scale mtDNA screening reveals a surprising matrilineal complexity in east Asia and its implications to the peopling of the region."
    Kong Q.P., Sun C., Wang H.W., Zhao M., Wang W.Z., Zhong L., Hao X.D., Pan H., Wang S.Y., Cheng Y.T., Zhu C.L., Wu S.F., Liu L.N., Jin J.Q., Yao Y.G., Zhang Y.P.
    Mol. Biol. Evol. 28:513-522(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "A "Copernican" reassessment of the human mitochondrial DNA tree from its root."
    Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M., Kivisild T., Torroni A., Villems R.
    Am. J. Hum. Genet. 90:675-684(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9B1M0_HUMAN
AccessioniPrimary (citable) accession number: Q9B1M0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.