Q9B1M0 (Q9B1M0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase chain 5 RuleBase RU003404
EC=1.6.5.3 RuleBase RU003404

Gene names

Name:

ND5 EMBL ABB78829.1

Encoded on

Mitochondrion EMBL AAK17893.1

Organism

Homo sapiens (Human) EMBL AAK17893.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. SAAS SAAS003945
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. SAAS SAAS003945 RuleBase RU003404
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity SAAS SAAS003945 RuleBase RU003404.
Sequence similarities	Belongs to the complex I subunit 5 family. RuleBase RU003404

Ontologies

Keywords
Biological process	Electron transport Respiratory chain SAAS SAAS003945 Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane SAAS SAAS003945
Domain	Transmembrane Transmembrane helix SAAS SAAS003945
Ligand	NAD SAAS SAAS003945 RuleBase RU000317 Ubiquinone SAAS SAAS003945 RuleBase RU000318
Molecular function	Oxidoreductase SAAS SAAS003945 RuleBase RU000317
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9B1M0 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2CCFF1B9AFF638EB	FASTA	603	67,012
	10 20 30 40 50 60 MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP TTMFMCLDQE 70 80 90 100 110 120 VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI MEFSLWYMNS DPNINQFFKY 130 140 150 160 170 180 LLIFLITMLI LVTANNLFQL FIGWEGVGIM SFLLISWWYA RADANTAAIQ AVLYNRIGDI 190 200 210 220 230 240 GFILALAWFI LHSNSWDPQQ MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP 250 260 270 280 290 300 TPVSALLHSS TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK 310 320 330 340 350 360 IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG 370 380 390 400 410 420 GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN MSYTNAWALS ITLIATSLTS 430 440 450 460 470 480 AYSTRMILLT LTGQPRFPTL TNINENNPTL LNPIKRLAAG SLFAGFLITN NISPASPFQT 490 500 510 520 530 540 TIPLYLKLTA LAVTFLGLLT ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL 550 560 570 580 590 600 GLLTSQNLPL LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL LIT

References

[1]	"Mitochondrial genome variation and the origin of modern humans." Ingman M., Kaessmann H., Paeaebo S., Gyllensten U. Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Ingman M., Kaessmann H., Paabo S., Gyllensten U. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The mtDNA legacy of the Levantine early Upper Palaeolithic in Africa." Olivieri A., Achilli A., pala M., Battaglia V., Fornarino S., Al-Zahery N., Scozzari R., Cruciani F., Behar D.M., Dugoujon J.-M., Coudray C., Santachiara-Benerecetti A.S., Semino O., Bandelt H.-J., Torroni A. Science 314:1767-1770(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 1_U6a EMBL ABJ99108.1.
[4]	"Complete mitochondrial genome sequences for 265 African American and U.S. "Hispanic" individuals." Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J. Forensic Sci. Int. Genet. 2:e45-e48(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: B2-2-03 EMBL ABB78829.1.
[5]	"The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations." Zou Y., Jia X., Zhang A.M., Wang W.Z., Li S., Guo X., Kong Q.P., Zhang Q., Yao Y.G. Biochem. Biophys. Res. Commun. 399:179-185(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: LHON family 370 EMBL ADB78170.1.
[6]	"Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6." Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B., Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., Macaulay V. BMC Evol. Biol. 10:390-390(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"The mitochondrial ND1 and ND5 genes are mutational hotspots for Chinese families with clinical features of Leber hereditary optic neuropathy but without the three primary mutations." Zou Y., Zhang A.-M., Yao Y.-G. Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: LHON family 370 EMBL ADB78170.1.
[8]	"Mitochondrial diversity of the sea nomads of Thailand." Pradutkanchana S., Ishida T., Kimura R. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[9]	Kong Q.-P., Sun C., Wang H.-W., Zhao M., Wang W.-Z., Zhong L., Hao X.-D., Pan H., Wang S.-Y., Cheng Y.-T., Zhu C.-L., Wu S.-F., Liu L.-N., Jin J.-Q., Yao Y.-G., Zhang Y.-P. Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	"Large-scale mtDNA screening reveals a surprising matrilineal complexity in east Asia and its implications to the peopling of the region." Kong Q.P., Sun C., Wang H.W., Zhao M., Wang W.Z., Zhong L., Hao X.D., Pan H., Wang S.Y., Cheng Y.T., Zhu C.L., Wu S.F., Liu L.N., Jin J.Q., Yao Y.G., Zhang Y.P. Mol. Biol. Evol. 28:513-522(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[11]	"A "Copernican" reassessment of the human mitochondrial DNA tree from its root." Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M., Kivisild T., Torroni A., Villems R. Am. J. Hum. Genet. 90:675-684(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF347004 Genomic DNA. Translation: AAK17750.1. AF347015 Genomic DNA. Translation: AAK17893.1. DQ282443 Genomic DNA. Translation: ABB78829.1. EF064317 Genomic DNA. Translation: ABJ99108.1. GU377083 Genomic DNA. Translation: ADB78170.1. GU810031 Genomic DNA. Translation: ADD53392.1. GU810040 Genomic DNA. Translation: ADD53509.1. HM030539 Genomic DNA. Translation: ADE33595.1. HQ651702 Genomic DNA. Translation: ADU77831.1. JQ705097 Genomic DNA. Translation: AFG04229.1.
IPI	IPI00008511.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG108343.
Family and domain databases
InterPro	IPR010934. NADH_DH_su5_C. IPR001750. NADH_UbQ/plastoQ_OxRdtase. IPR001516. NADH_UbQ_OxRdtase_chain5/L_N. IPR003945. NADHpl_OxRdtase_5. [Graphical view]
Pfam	PF06455. NADH5_C. 1 hit. PF00361. Oxidored_q1. 1 hit. PF00662. Oxidored_q1_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01974. NDH_I_L. 1 hit.
ProtoNet	Search...
Other
NextBio	35541626.

Entry information

Entry name

Q9B1M0_HUMAN

Accession

Primary (citable) accession number: Q9B1M0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.