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Q9B1M0

- Q9B1M0_HUMAN

UniProt

Q9B1M0 - Q9B1M0_HUMAN

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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene
ND5
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.SAAS annotations

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotations

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotations

Keywords - Biological processi

Electron transport, Respiratory chainSAAS annotations, Transport

Keywords - Ligandi

NADUniRule annotationSAAS annotations, UbiquinoneUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:ND5Imported
Encoded oniMitochondrionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiQ9B1M0.

Structurei

3D structure databases

ProteinModelPortaliQ9B1M0.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG108343.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9B1M0-1 [UniParc]FASTAAdd to Basket

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MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP    50
TTMFMCLDQE VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI 100
MEFSLWYMNS DPNINQFFKY LLIFLITMLI LVTANNLFQL FIGWEGVGIM 150
SFLLISWWYA RADANTAAIQ AVLYNRIGDI GFILALAWFI LHSNSWDPQQ 200
MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP TPVSALLHSS 250
TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK 300
IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL 350
NNEQDIRKMG GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN 400
MSYTNAWALS ITLIATSLTS AYSTRMILLT LTGQPRFPTL TNINENNPTL 450
LNPIKRLAAG SLFAGFLITN NISPASPFQT TIPLYLKLTA LAVTFLGLLT 500
ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL GLLTSQNLPL 550
LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL 600
LIT 603
Length:603
Mass (Da):67,012
Last modified:June 1, 2001 - v1
Checksum:i2CCFF1B9AFF638EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF347004 Genomic DNA. Translation: AAK17750.1.
AF347015 Genomic DNA. Translation: AAK17893.1.
DQ282443 Genomic DNA. Translation: ABB78829.1.
EF064317 Genomic DNA. Translation: ABJ99108.1.
GU377083 Genomic DNA. Translation: ADB78170.1.
GU810031 Genomic DNA. Translation: ADD53392.1.
GU810040 Genomic DNA. Translation: ADD53509.1.
HM030539 Genomic DNA. Translation: ADE33595.1.
HQ651702 Genomic DNA. Translation: ADU77831.1.
JQ705097 Genomic DNA. Translation: AFG04229.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF347004 Genomic DNA. Translation: AAK17750.1 .
AF347015 Genomic DNA. Translation: AAK17893.1 .
DQ282443 Genomic DNA. Translation: ABB78829.1 .
EF064317 Genomic DNA. Translation: ABJ99108.1 .
GU377083 Genomic DNA. Translation: ADB78170.1 .
GU810031 Genomic DNA. Translation: ADD53392.1 .
GU810040 Genomic DNA. Translation: ADD53509.1 .
HM030539 Genomic DNA. Translation: ADE33595.1 .
HQ651702 Genomic DNA. Translation: ADU77831.1 .
JQ705097 Genomic DNA. Translation: AFG04229.1 .

3D structure databases

ProteinModelPortali Q9B1M0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9B1M0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108343.

Miscellaneous databases

NextBioi 35541626.

Family and domain databases

InterProi IPR010934. NADH_DH_su5_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
[Graphical view ]
Pfami PF06455. NADH5_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01974. NDH_I_L. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial genome variation and the origin of modern humans."
    Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
    Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Ingman M., Kaessmann H., Paabo S., Gyllensten U.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1_U6aImported.
  4. "Complete mitochondrial genome sequences for 265 African American and U.S. "Hispanic" individuals."
    Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J.
    Forensic Sci. Int. Genet. 2:e45-e48(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B2-2-03Imported.
  5. "The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations."
    Zou Y., Jia X., Zhang A.M., Wang W.Z., Li S., Guo X., Kong Q.P., Zhang Q., Yao Y.G.
    Biochem. Biophys. Res. Commun. 399:179-185(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LHON family 370Imported.
  6. "Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6."
    Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B., Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., Macaulay V.
    BMC Evol. Biol. 10:390-390(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "The mitochondrial ND1 and ND5 genes are mutational hotspots for Chinese families with clinical features of Leber hereditary optic neuropathy but without the three primary mutations."
    Zou Y., Zhang A.-M., Yao Y.-G.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LHON family 370Imported.
  8. "Mitochondrial diversity of the sea nomads of Thailand."
    Pradutkanchana S., Ishida T., Kimura R.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Cited for: NUCLEOTIDE SEQUENCE.
  10. "Large-scale mtDNA screening reveals a surprising matrilineal complexity in east Asia and its implications to the peopling of the region."
    Kong Q.P., Sun C., Wang H.W., Zhao M., Wang W.Z., Zhong L., Hao X.D., Pan H., Wang S.Y., Cheng Y.T., Zhu C.L., Wu S.F., Liu L.N., Jin J.Q., Yao Y.G., Zhang Y.P.
    Mol. Biol. Evol. 28:513-522(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "A "Copernican" reassessment of the human mitochondrial DNA tree from its root."
    Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M., Kivisild T., Torroni A., Villems R.
    Am. J. Hum. Genet. 90:675-684(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9B1M0_HUMAN
AccessioniPrimary (citable) accession number: Q9B1M0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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