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Q9B1M0 (Q9B1M0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 5 RuleBase RU003404

EC=1.6.5.3 RuleBase RU003404
Gene names
Name:ND5 EMBL ABB78829.1
Encoded onMitochondrion EMBL AAK17893.1
OrganismHomo sapiens (Human) EMBL AAK17893.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. SAAS SAAS010934

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). RuleBase RU003404 SAAS SAAS010934

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity RuleBase RU003404 SAAS SAAS010934.

Sequence similarities

Belongs to the complex I subunit 5 family. RuleBase RU003404

Sequences

Sequence LengthMass (Da)Tools
Q9B1M0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2CCFF1B9AFF638EB

FASTA60367,012
        10         20         30         40         50         60 
MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP TTMFMCLDQE 

        70         80         90        100        110        120 
VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI MEFSLWYMNS DPNINQFFKY 

       130        140        150        160        170        180 
LLIFLITMLI LVTANNLFQL FIGWEGVGIM SFLLISWWYA RADANTAAIQ AVLYNRIGDI 

       190        200        210        220        230        240 
GFILALAWFI LHSNSWDPQQ MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP 

       250        260        270        280        290        300 
TPVSALLHSS TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK 

       310        320        330        340        350        360 
IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG 

       370        380        390        400        410        420 
GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN MSYTNAWALS ITLIATSLTS 

       430        440        450        460        470        480 
AYSTRMILLT LTGQPRFPTL TNINENNPTL LNPIKRLAAG SLFAGFLITN NISPASPFQT 

       490        500        510        520        530        540 
TIPLYLKLTA LAVTFLGLLT ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL 

       550        560        570        580        590        600 
GLLTSQNLPL LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL 


LIT 

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References

[1]"Mitochondrial genome variation and the origin of modern humans."
Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Ingman M., Kaessmann H., Paabo S., Gyllensten U.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The mtDNA legacy of the Levantine early Upper Palaeolithic in Africa."
Olivieri A., Achilli A., pala M., Battaglia V., Fornarino S., Al-Zahery N., Scozzari R., Cruciani F., Behar D.M., Dugoujon J.-M., Coudray C., Santachiara-Benerecetti A.S., Semino O., Bandelt H.-J., Torroni A.
Science 314:1767-1770(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 1_U6a EMBL ABJ99108.1.
[4]"Complete mitochondrial genome sequences for 265 African American and U.S. "Hispanic" individuals."
Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J.
Forensic Sci. Int. Genet. 2:e45-e48(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B2-2-03 EMBL ABB78829.1.
[5]"The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations."
Zou Y., Jia X., Zhang A.M., Wang W.Z., Li S., Guo X., Kong Q.P., Zhang Q., Yao Y.G.
Biochem. Biophys. Res. Commun. 399:179-185(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: LHON family 370 EMBL ADB78170.1.
[6]"Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6."
Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B., Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., Macaulay V.
BMC Evol. Biol. 10:390-390(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[7]"The mitochondrial ND1 and ND5 genes are mutational hotspots for Chinese families with clinical features of Leber hereditary optic neuropathy but without the three primary mutations."
Zou Y., Zhang A.-M., Yao Y.-G.
Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: LHON family 370 EMBL ADB78170.1.
[8]"Mitochondrial diversity of the sea nomads of Thailand."
Pradutkanchana S., Ishida T., Kimura R.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[9]Kong Q.-P., Sun C., Wang H.-W., Zhao M., Wang W.-Z., Zhong L., Hao X.-D., Pan H., Wang S.-Y., Cheng Y.-T., Zhu C.-L., Wu S.-F., Liu L.-N., Jin J.-Q., Yao Y.-G., Zhang Y.-P.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[10]"Large-scale mtDNA screening reveals a surprising matrilineal complexity in east Asia and its implications to the peopling of the region."
Kong Q.P., Sun C., Wang H.W., Zhao M., Wang W.Z., Zhong L., Hao X.D., Pan H., Wang S.Y., Cheng Y.T., Zhu C.L., Wu S.F., Liu L.N., Jin J.Q., Yao Y.G., Zhang Y.P.
Mol. Biol. Evol. 28:513-522(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[11]"A "Copernican" reassessment of the human mitochondrial DNA tree from its root."
Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M., Kivisild T., Torroni A., Villems R.
Am. J. Hum. Genet. 90:675-684(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF347004 Genomic DNA. Translation: AAK17750.1.
AF347015 Genomic DNA. Translation: AAK17893.1.
DQ282443 Genomic DNA. Translation: ABB78829.1.
EF064317 Genomic DNA. Translation: ABJ99108.1.
GU377083 Genomic DNA. Translation: ADB78170.1.
GU810031 Genomic DNA. Translation: ADD53392.1.
GU810040 Genomic DNA. Translation: ADD53509.1.
HM030539 Genomic DNA. Translation: ADE33595.1.
HQ651702 Genomic DNA. Translation: ADU77831.1.
JQ705097 Genomic DNA. Translation: AFG04229.1.

3D structure databases

ProteinModelPortalQ9B1M0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9B1M0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108343.
PhylomeDBQ9B1M0.

Family and domain databases

InterProIPR010934. NADH_DH_su5_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
[Graphical view]
PfamPF06455. NADH5_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01974. NDH_I_L. 1 hit.
ProtoNetSearch...

Other

NextBio35541626.

Entry information

Entry nameQ9B1M0_HUMAN
AccessionPrimary (citable) accession number: Q9B1M0
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.