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Q9B1M0

- Q9B1M0_HUMAN

UniProt

Q9B1M0 - Q9B1M0_HUMAN

Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Electron transport, Respiratory chainSAAS annotation, Transport

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 5UniRule annotation (EC:1.6.5.3UniRule annotation)
    Gene namesi
    Name:ND5Imported
    Encoded oniMitochondrionImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9B1M0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9B1M0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 5 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG108343.

    Family and domain databases

    InterProiIPR010934. NADH_DH_su5_C.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
    IPR003945. NADHpl_OxRdtase_5.
    [Graphical view]
    PfamiPF06455. NADH5_C. 1 hit.
    PF00361. Oxidored_q1. 1 hit.
    PF00662. Oxidored_q1_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9B1M0-1 [UniParc]FASTAAdd to Basket

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    MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP    50
    TTMFMCLDQE VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI 100
    MEFSLWYMNS DPNINQFFKY LLIFLITMLI LVTANNLFQL FIGWEGVGIM 150
    SFLLISWWYA RADANTAAIQ AVLYNRIGDI GFILALAWFI LHSNSWDPQQ 200
    MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP TPVSALLHSS 250
    TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK 300
    IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL 350
    NNEQDIRKMG GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN 400
    MSYTNAWALS ITLIATSLTS AYSTRMILLT LTGQPRFPTL TNINENNPTL 450
    LNPIKRLAAG SLFAGFLITN NISPASPFQT TIPLYLKLTA LAVTFLGLLT 500
    ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL GLLTSQNLPL 550
    LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL 600
    LIT 603
    Length:603
    Mass (Da):67,012
    Last modified:June 1, 2001 - v1
    Checksum:i2CCFF1B9AFF638EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF347004 Genomic DNA. Translation: AAK17750.1.
    AF347015 Genomic DNA. Translation: AAK17893.1.
    DQ282443 Genomic DNA. Translation: ABB78829.1.
    EF064317 Genomic DNA. Translation: ABJ99108.1.
    GU377083 Genomic DNA. Translation: ADB78170.1.
    GU810031 Genomic DNA. Translation: ADD53392.1.
    GU810040 Genomic DNA. Translation: ADD53509.1.
    HM030539 Genomic DNA. Translation: ADE33595.1.
    HQ651702 Genomic DNA. Translation: ADU77831.1.
    JQ705097 Genomic DNA. Translation: AFG04229.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF347004 Genomic DNA. Translation: AAK17750.1 .
    AF347015 Genomic DNA. Translation: AAK17893.1 .
    DQ282443 Genomic DNA. Translation: ABB78829.1 .
    EF064317 Genomic DNA. Translation: ABJ99108.1 .
    GU377083 Genomic DNA. Translation: ADB78170.1 .
    GU810031 Genomic DNA. Translation: ADD53392.1 .
    GU810040 Genomic DNA. Translation: ADD53509.1 .
    HM030539 Genomic DNA. Translation: ADE33595.1 .
    HQ651702 Genomic DNA. Translation: ADU77831.1 .
    JQ705097 Genomic DNA. Translation: AFG04229.1 .

    3D structure databases

    ProteinModelPortali Q9B1M0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9B1M0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108343.

    Miscellaneous databases

    NextBioi 35541626.

    Family and domain databases

    InterProi IPR010934. NADH_DH_su5_C.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
    IPR003945. NADHpl_OxRdtase_5.
    [Graphical view ]
    Pfami PF06455. NADH5_C. 1 hit.
    PF00361. Oxidored_q1. 1 hit.
    PF00662. Oxidored_q1_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01974. NDH_I_L. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial genome variation and the origin of modern humans."
      Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
      Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Ingman M., Kaessmann H., Paabo S., Gyllensten U.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1_U6aImported.
    4. "Complete mitochondrial genome sequences for 265 African American and U.S. "Hispanic" individuals."
      Just R.S., Diegoli T.M., Saunier J.L., Irwin J.A., Parsons T.J.
      Forensic Sci. Int. Genet. 2:e45-e48(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B2-2-03Imported.
    5. "The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations."
      Zou Y., Jia X., Zhang A.M., Wang W.Z., Li S., Guo X., Kong Q.P., Zhang Q., Yao Y.G.
      Biochem. Biophys. Res. Commun. 399:179-185(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LHON family 370Imported.
    6. "Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6."
      Pereira L., Silva N.M., Franco-Duarte R., Fernandes V., Pereira J.B., Costa M.D., Martins H., Soares P., Behar D.M., Richards M.B., Macaulay V.
      BMC Evol. Biol. 10:390-390(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "The mitochondrial ND1 and ND5 genes are mutational hotspots for Chinese families with clinical features of Leber hereditary optic neuropathy but without the three primary mutations."
      Zou Y., Zhang A.-M., Yao Y.-G.
      Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LHON family 370Imported.
    8. "Mitochondrial diversity of the sea nomads of Thailand."
      Pradutkanchana S., Ishida T., Kimura R.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. Cited for: NUCLEOTIDE SEQUENCE.
    10. "Large-scale mtDNA screening reveals a surprising matrilineal complexity in east Asia and its implications to the peopling of the region."
      Kong Q.P., Sun C., Wang H.W., Zhao M., Wang W.Z., Zhong L., Hao X.D., Pan H., Wang S.Y., Cheng Y.T., Zhu C.L., Wu S.F., Liu L.N., Jin J.Q., Yao Y.G., Zhang Y.P.
      Mol. Biol. Evol. 28:513-522(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    11. "A "Copernican" reassessment of the human mitochondrial DNA tree from its root."
      Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M., Kivisild T., Torroni A., Villems R.
      Am. J. Hum. Genet. 90:675-684(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9B1M0_HUMAN
    AccessioniPrimary (citable) accession number: Q9B1M0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.