Reviewed, UniProtKB/Swiss-Prot Q9AXB0 (DCUP1_ORYSJ)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase 1, chloroplastic
      Short name=URO-D1
      Short name=UPD1
    EC=4.1.1.37

Gene names

Ordered Locus Names:	Os01g0622300, LOC_Os01g43390
ORF Names:	P0501G01.7, OsJ_02650

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast Probable.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Porphyrin biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 50	50	Chloroplast Potential
	Chain	51 – 402	352	Uroporphyrinogen decarboxylase 1, chloroplastic		PRO_0000376072
Regions
	Region	67 – 71	5	Substrate binding By similarity
Sites
	Binding site	86	1	Substrate By similarity
	Binding site	116	1	Substrate By similarity
	Binding site	117	1	Substrate By similarity
	Binding site	193	1	Substrate By similarity
	Binding site	248	1	Substrate By similarity
	Binding site	363	1	Substrate By similarity
	Site	117	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9AXB0-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9CFC02F92949F327	FASTA	402	43,982
	10 20 30 40 50 60 MISATATAAF LAAAPASSSS CTTHRRRSGL PAISASLATA SSTEEPLLVR AARGEDGLPR 70 80 90 100 110 120 PPAWMMRQAG RYMAEYQALA KRHPSFRERS ETTELIVEIT LQPWRAFAPD GVILFSDILT 130 140 150 160 170 180 PLPAIGVPFD ISDSKGPVIQ SPVRSEEQVR ELTPIDFEKL RFVGESLKIL RTEIDGQAAL 190 200 210 220 230 240 LGFVGAPWTI ATYVVEGGMT NTYTNIKSMC HTAPNVLRGL LSHLADAISE YIIYQVNSGA 250 260 270 280 290 300 QCIQIFDSWG GQLPPHVWEQ WSKPYIKQIV NKIKIECPNV PLVLYINGNG GLLERMTDTG 310 320 330 340 350 360 VDVIGLDWTV DMADGRRRLG NKISVQGNVD PAFLFSPLPV LTDEIHRVVK SAGPKGHILN 370 380 390 400 LGHGVLVKTP EEAVAHFFDV TRSLRYDTLF QGCVTEVLEP VA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[5]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP002819 Genomic DNA. Translation: BAB21078.1. AP008207 Genomic DNA. Translation: BAF05524.1. CM000138 Genomic DNA. Translation: EEE55007.1. AK106203 mRNA. Translation: BAG97638.1.
RefSeq	NP_001043610.1.
UniGene	Os.32068
3D structure databases
HSSP	HSSP built from PDB template 1J93 based on UniProtKB Q42967.
ModBase	Search...
Genome annotation databases
GeneID	4326635.
KEGG	osa:4326635.
NMPDR	fig|39947.1.peg.9810.
Organism-specific databases
Gramene	Q9AXB0.
Family and domain databases
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP1_ORYSJ

Accession

Primary (citable) accession number: Q9AXB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	June 1, 2001
Last modified:	October 13, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)