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Protein

DNA repair protein UVH3

Gene

UVH3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3'-incision step in NER. Seems to play a role in senescence program.1 Publication

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi30 – 301Magnesium 1By similarity
Metal bindingi77 – 771Magnesium 1By similarity
Metal bindingi946 – 9461Magnesium 1By similarity
Metal bindingi948 – 9481Magnesium 1By similarity
Metal bindingi967 – 9671Magnesium 2By similarity
Metal bindingi969 – 9691Magnesium 2By similarity
Metal bindingi1018 – 10181Magnesium 2By similarity

GO - Molecular functioni

GO - Biological processi

  • non-photoreactive DNA repair Source: TAIR
  • nucleotide-excision repair Source: InterPro
  • response to heat Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-5696395. Formation of Incision Complex in GG-NER.
R-ATH-5696400. Dual Incision in GG-NER.
R-ATH-6782135. Dual incision in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein UVH3 (EC:3.1.-.-)
Alternative name(s):
ERCC5 homolog
RAD2 homolog
Short name:
AtRAD2
Short name:
AtUVH3
Short name:
AtXPG
UV hypersensitive protein 3
XPG homolog
Gene namesi
Name:UVH3
Synonyms:RAD2, XPG
Ordered Locus Names:At3g28030
ORF Names:MMG15.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G28030.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14791479DNA repair protein UVH3PRO_0000154034Add
BLAST

Proteomic databases

PaxDbiQ9ATY5.
PRIDEiQ9ATY5.

PTM databases

iPTMnetiQ9ATY5.

Expressioni

Tissue specificityi

Expressed in all tissues at low levels.1 Publication

Gene expression databases

GenevisibleiQ9ATY5. AT.

Interactioni

Protein-protein interaction databases

BioGridi7757. 2 interactions.
IntActiQ9ATY5. 1 interaction.
STRINGi3702.AT3G28030.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ATY5.
SMRiQ9ATY5. Positions 2-114, 883-1169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9898N-domainAdd
BLAST
Regioni934 – 102289I-domainAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2520. Eukaryota.
COG0258. LUCA.
HOGENOMiHOG000083663.
InParanoidiQ9ATY5.
KOiK10846.
OMAiFQATMRD.
OrthoDBiEOG093600DF.
PhylomeDBiQ9ATY5.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR11081. PTHR11081. 2 hits.
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00853. XPGRADSUPER.
PR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 2 hits.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ATY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQGLWELL APVGRRVSVE TLANKRLAID ASIWMVQFIK AMRDEKGDMV
60 70 80 90 100
QNAHLIGFFR RICKLLFLRT KPIFVFDGAT PALKRRTVIA RRRQRENAQT
110 120 130 140 150
KIRKTAEKLL LNRLKDIRLK EQAKDIKNQR LKQDDSDRVK KRVSSDSVED
160 170 180 190 200
NLRVPVEEDD VGASFFQEEK LDEVSQASLV GETGVDDVVK ESVKDDPKGK
210 220 230 240 250
GVLLDGDDLD NLVQDSSVQG KDYQEKLDEM LAASLAAEEE RNFTSKASTS
260 270 280 290 300
AAAIPSEEDE EEDSDGDEEI LLPVMDGNID PAVLASLPPS MQLDLLAQMR
310 320 330 340 350
EKLMAENRQK YQKVKKAPEK FSELQIEAYL KTVAFRREIN EVQRSAGGRA
360 370 380 390 400
VGGVQTSRIA SEANREFIFS SSFAGDKEVL ASAREGRNDE NQKKTSQQSL
410 420 430 440 450
PVSVKNASPL KKSDATIELD RDEPKNPDEN IEVYIDERGR FRIRNRHMGI
460 470 480 490 500
QMTRDIQRNL HLMKEKERTA SGSMAKNDET FSAWENFPTE DQFLEKSPVE
510 520 530 540 550
KDVVDLEIQN DDSMLHPPSS IEISFDHDGG GKDLNDEDDM FLQLAAGGPV
560 570 580 590 600
TISSTENDPK EDTSPWASDS DWEEVPVEQN TSVSKLEANL SNQHIPKDIS
610 620 630 640 650
IAEGVAWEEY SCKNANNSVE NDTVTKITKG YLEEEADLQE AIKKSLLELH
660 670 680 690 700
DKESGDVLEE NQSVRVNLVV DKPSEDSLCS RETVGEAEEE RFLDEITILK
710 720 730 740 750
TSGAISEQSN TSVAGNADGQ KGITKQFGTH PSSGSNNVSH AVSNKLSKVK
760 770 780 790 800
SVISPEKALN VASQNRMLST MAKQHNEEGS ESFGGESVKV SAMPIADEEI
810 820 830 840 850
TGFLDEKDNA DGESSIMMDD KRDYSRRKIQ SLVTESRDPS RNVVRSRIGI
860 870 880 890 900
LHDTDSQNER REENNSNEHT FNIDSSTDFE EKGVPVEFSE ANIEEEIRVL
910 920 930 940 950
DQEFVSLGDE QRKLERNAES VSSEMFAECQ ELLQIFGIPY IIAPMEAEAQ
960 970 980 990 1000
CAFMEQSNLV DGIVTDDSDV FLFGARSVYK NIFDDRKYVE TYFMKDIEKE
1010 1020 1030 1040 1050
LGLSRDKIIR MAMLLGSDYT EGISGIGIVN AIEVVTAFPE EDGLQKFREW
1060 1070 1080 1090 1100
VESPDPTILG KTDAKTGSKV KKRGSASVDN KGIISGASTD DTEEIKQIFM
1110 1120 1130 1140 1150
DQHRKVSKNW HIPLTFPSEA VISAYLNPQV DLSTEKFSWG KPDLSVLRKL
1160 1170 1180 1190 1200
CWEKFNWNGK KTDELLLPVL KEYEKRETQL RIEAFYSFNE RFAKIRSKRI
1210 1220 1230 1240 1250
NKAVKGIGGG LSSDVADHTL QEGPRKRNKK KVAPHETEDN NTSDKDSPIA
1260 1270 1280 1290 1300
NEKVKNKRKR LEKPSSSRGR GRAQKRGRGR GRVQKDLLEL SDGSSDDDDD
1310 1320 1330 1340 1350
DDKVVELEAK PANLQKSTRS RNPVMYSAKE DDELDESRSN EGSPSENFEE
1360 1370 1380 1390 1400
VDEGRIGNDD SVDASINDCP SEDYIQTGGG FCADEADEIG DAHLEDKATD
1410 1420 1430 1440 1450
DYRVIGGGFC VDEDETAEEN TMDDDAEILK MESEEQRKKG KRRNEEDASL
1460 1470
DENVDIHFGN SSAGGLSAMP FLKRKKRKN
Length:1,479
Mass (Da):165,668
Last modified:June 1, 2001 - v1
Checksum:i72F38D472849EE55
GO

Sequence cautioni

The sequence BAB01125 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312711 mRNA. Translation: AAK37472.1.
AB028616 Genomic DNA. Translation: BAB01125.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE77393.1.
RefSeqiNP_566830.1. NM_113721.1.
UniGeneiAt.5484.

Genome annotation databases

EnsemblPlantsiAT3G28030.1; AT3G28030.1; AT3G28030.
GeneIDi822427.
GrameneiAT3G28030.1; AT3G28030.1; AT3G28030.
KEGGiath:AT3G28030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312711 mRNA. Translation: AAK37472.1.
AB028616 Genomic DNA. Translation: BAB01125.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE77393.1.
RefSeqiNP_566830.1. NM_113721.1.
UniGeneiAt.5484.

3D structure databases

ProteinModelPortaliQ9ATY5.
SMRiQ9ATY5. Positions 2-114, 883-1169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7757. 2 interactions.
IntActiQ9ATY5. 1 interaction.
STRINGi3702.AT3G28030.1.

PTM databases

iPTMnetiQ9ATY5.

Proteomic databases

PaxDbiQ9ATY5.
PRIDEiQ9ATY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G28030.1; AT3G28030.1; AT3G28030.
GeneIDi822427.
GrameneiAT3G28030.1; AT3G28030.1; AT3G28030.
KEGGiath:AT3G28030.

Organism-specific databases

TAIRiAT3G28030.

Phylogenomic databases

eggNOGiKOG2520. Eukaryota.
COG0258. LUCA.
HOGENOMiHOG000083663.
InParanoidiQ9ATY5.
KOiK10846.
OMAiFQATMRD.
OrthoDBiEOG093600DF.
PhylomeDBiQ9ATY5.

Enzyme and pathway databases

ReactomeiR-ATH-5696395. Formation of Incision Complex in GG-NER.
R-ATH-5696400. Dual Incision in GG-NER.
R-ATH-6782135. Dual incision in TC-NER.

Miscellaneous databases

PROiQ9ATY5.

Gene expression databases

GenevisibleiQ9ATY5. AT.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR11081. PTHR11081. 2 hits.
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00853. XPGRADSUPER.
PR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 2 hits.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVH3_ARATH
AccessioniPrimary (citable) accession number: Q9ATY5
Secondary accession number(s): Q9LRT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.