Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cationic amino acid transporter 2, vacuolar

Gene

CAT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Permease involved in the transport of the cationic amino acids.By similarity

GO - Molecular functioni

GO - Biological processi

  • amino acid homeostasis Source: TAIR
  • L-alpha-amino acid transmembrane transport Source: GOC
  • L-amino acid transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.13. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 2, vacuolar
Gene namesi
Name:CAT2
Ordered Locus Names:At1g58030
ORF Names:T15M6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G58030.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848CytoplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 767VacuolarSequence analysis
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Topological domaini98 – 10811CytoplasmicSequence analysisAdd
BLAST
Transmembranei109 – 13123HelicalSequence analysisAdd
BLAST
Topological domaini132 – 17140VacuolarSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Topological domaini193 – 2008CytoplasmicSequence analysis
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Topological domaini222 – 23514VacuolarSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 28024CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 32423VacuolarSequence analysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 37631CytoplasmicSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Topological domaini398 – 3981VacuolarSequence analysis
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Topological domaini420 – 49374CytoplasmicSequence analysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence analysisAdd
BLAST
Topological domaini515 – 52410VacuolarSequence analysis
Transmembranei525 – 54521HelicalSequence analysisAdd
BLAST
Topological domaini546 – 56015CytoplasmicSequence analysisAdd
BLAST
Transmembranei561 – 58121HelicalSequence analysisAdd
BLAST
Topological domaini582 – 5854VacuolarSequence analysis
Transmembranei586 – 60621HelicalSequence analysisAdd
BLAST
Topological domaini607 – 63529CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plant-type vacuole membrane Source: TAIR
  • vacuolar membrane Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Cationic amino acid transporter 2, vacuolarPRO_0000415778Add
BLAST

Proteomic databases

PaxDbiQ9ASS7.
PRIDEiQ9ASS7.

Expressioni

Tissue specificityi

Expressed in roots, stems, flowers, leaves, and siliques.1 Publication

Gene expression databases

GenevisibleiQ9ASS7. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G58030.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ASS7.
SMRiQ9ASS7. Positions 55-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
InParanoidiQ9ASS7.
OMAiARICYAM.
PhylomeDBiQ9ASS7.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ASS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLVDTQKE GGGHSWGYVR SLVRRKQVDS ANGQSHGHQL ARALTVPHLV
60 70 80 90 100
AIGVGATIGA GVYILVGTVA REHSGPSLAL SFLIAGIAAG LSAFCYAELS
110 120 130 140 150
SRCPSAGSAY HYSYICVGEG VAWIIGWALI LEYTIGGSAV ARGISPNLAL
160 170 180 190 200
IFGGEDGLPA ILARHQIPGL DIVVDPCAAI LVFVVTGLLC MGIKESTFAQ
210 220 230 240 250
GIVTAVNVCV LLFVIVAGSY LGFKTGWPGY ELPTGFFPFG VDGMFAGSAT
260 270 280 290 300
VFFAFIGFDS VASTAEEVRN PQRDLPIGIG LALLLCCSLY MMVSIVIVGL
310 320 330 340 350
IPYYAMDPDT PISSAFASHD MQWAVYLITL GAVMALCSAL MGALLPQPRI
360 370 380 390 400
LMAMARDGLL PSIFSDINKR TQVPVKATVA TGLCAATLAF FMDVSQLAGM
410 420 430 440 450
VSVGTLLAFT MVAISVLILR YVPPDEQPLP SSLQERIDSV SFICGETTSS
460 470 480 490 500
GHVGTSDSSH QPLIVNNDAL VDVPLIKNQE ALGCLVLSEE TRRIVAGWSI
510 520 530 540 550
MFTCVGAFLL SYAASSLSFP GLIRYPLCGV GGCLLLAGLI ALSSIDQDDA
560 570 580 590 600
RHTFGHSGGY MCPFVPLLPI ICILINMYLL VNLGSATWAR VSVWLLIGVI
610 620 630
VYVFYGRKNS SLANAVYVTT AHAEEIYREH EGSLA
Length:635
Mass (Da):67,115
Last modified:June 1, 2001 - v1
Checksum:i34F3D17A57DF738E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti391 – 3911F → I in AAN17434 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079604 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE33488.1.
AF367304 mRNA. Translation: AAK32891.1.
BT000457 mRNA. Translation: AAN17434.1.
BT046174 mRNA. Translation: ACI49773.1.
RefSeqiNP_849822.1. NM_179491.2.
UniGeneiAt.43759.

Genome annotation databases

EnsemblPlantsiAT1G58030.1; AT1G58030.1; AT1G58030.
GeneIDi842170.
GrameneiAT1G58030.1; AT1G58030.1; AT1G58030.
KEGGiath:AT1G58030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079604 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE33488.1.
AF367304 mRNA. Translation: AAK32891.1.
BT000457 mRNA. Translation: AAN17434.1.
BT046174 mRNA. Translation: ACI49773.1.
RefSeqiNP_849822.1. NM_179491.2.
UniGeneiAt.43759.

3D structure databases

ProteinModelPortaliQ9ASS7.
SMRiQ9ASS7. Positions 55-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G58030.1.

Protein family/group databases

TCDBi2.A.3.3.13. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiQ9ASS7.
PRIDEiQ9ASS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G58030.1; AT1G58030.1; AT1G58030.
GeneIDi842170.
GrameneiAT1G58030.1; AT1G58030.1; AT1G58030.
KEGGiath:AT1G58030.

Organism-specific databases

TAIRiAT1G58030.

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
InParanoidiQ9ASS7.
OMAiARICYAM.
PhylomeDBiQ9ASS7.

Enzyme and pathway databases

ReactomeiR-ATH-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ9ASS7.

Gene expression databases

GenevisibleiQ9ASS7. AT.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Molecular and functional characterization of a family of amino acid transporters from Arabidopsis."
    Su Y.-H., Frommer W.B., Ludewig U.
    Plant Physiol. 136:3104-3113(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.
    Strain: cv. Columbia.
  6. "A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture."
    Jaquinod M., Villiers F., Kieffer-Jaquinod S., Hugouvieux V., Bruley C., Garin J., Bourguignon J.
    Mol. Cell. Proteomics 6:394-412(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAAT2_ARATH
AccessioniPrimary (citable) accession number: Q9ASS7
Secondary accession number(s): Q8H182
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 1, 2001
Last modified: February 17, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.