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Protein

Tubulin beta-3 chain

Gene

TUBB3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Miscellaneous

There are nine genes coding for beta-tubulin. The sequences coded by genes 2 and 3 are identical.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 146GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-5617833 Cilium Assembly
R-ATH-6798695 Neutrophil degranulation
R-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-ATH-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-3 chain
Gene namesi
Name:TUBB3
Synonyms:TUB3
Ordered Locus Names:At5g62700
ORF Names:MRG21.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G62700

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004195231 – 450Tubulin beta-3 chainAdd BLAST450

Proteomic databases

PRIDEiQ9ASR0

Expressioni

Gene expression databases

ExpressionAtlasiQ9ASR0 baseline and differential
GenevisibleiQ9ASR0 AT

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi21633, 5 interactors
21634, 3 interactors
IntActiQ9ASR0, 1 interactor
MINTiQ9ASR0

Structurei

3D structure databases

ProteinModelPortaliQ9ASR0
SMRiQ9ASR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
InParanoidiQ9ASR0
KOiK07375
OrthoDBiEOG093609OI
PhylomeDBiQ9ASR0

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ASR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREILHIQGG QCGNQIGAKF WEVVCAEHGI DPTGRYTGDS DLQLERINVY
60 70 80 90 100
YNEASCGRFV PRAVLMDLEP GTMDSLRSGP YGQTFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELIDSVLDVV RKEAENCDCL QGFQVCHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRMMLTFSVF PSPKVSDTVV EPYNATLSVH QLVENADECM
210 220 230 240 250
VLDNEALYDI CFRTLKLTTP SFGDLNHLIS ATMSGVTCCL RFPGQLNSDL
260 270 280 290 300
RKLAVNLIPF PRLHFFMVGF APLTSRGSQQ YRSLTVPELT QQMWDSKNMM
310 320 330 340 350
CAADPRHGRY LTASAMFRGK MSTKEVDEQM LNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
STVCDIPPTG LKMASTFIGN STSIQEMFRR VSEQFTAMFR RKAFLHWYTG
410 420 430 440 450
EGMDEMEFTE AESNMNDLVS EYQQYQDATA DEEGDYEDEE EGEYQQEEEY
Length:450
Mass (Da):50,734
Last modified:October 3, 2012 - v2
Checksum:iDF4C996D75A9A219
GO

Sequence cautioni

The sequence AAK32919 differs from that shown. Reason: Frameshift at position 337.Curated
The sequence AAM16247 differs from that shown. Reason: Frameshift at position 337.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84701 Genomic DNA Translation: AAA32882.1
AB009053, AB020751 Genomic DNA Translation: BAB10838.1
CP002688 Genomic DNA Translation: AED97644.1
AF367332 mRNA Translation: AAK32919.1 Frameshift.
AY060550 mRNA Translation: AAL31181.1
AY093986 mRNA Translation: AAM16247.1 Frameshift.
PIRiJQ1587
RefSeqiNP_568959.1, NM_125664.4
NP_568960.1, NM_125665.4
UniGeneiAt.24202
At.49208

Genome annotation databases

EnsemblPlantsiAT5G62690.1; AT5G62690.1; AT5G62690
AT5G62700.1; AT5G62700.1; AT5G62700
GeneIDi836390
836391
GrameneiAT5G62690.1; AT5G62690.1; AT5G62690
AT5G62700.1; AT5G62700.1; AT5G62700
KEGGiath:AT5G62690
ath:AT5G62700

Similar proteinsi

Entry informationi

Entry nameiTBB3_ARATH
AccessioniPrimary (citable) accession number: Q9ASR0
Secondary accession number(s): P29512
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: April 25, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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