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Protein

DNA (cytosine-5)-methyltransferase 2

Gene

ZMET5

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the CpXpG methylation and in gene silencing.By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei521PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi5016 M.ZmaV

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 2 (EC:2.1.1.37)
Alternative name(s):
Chromomethylase 2
DNA cytosine methyltransferase MET5
Zea methyltransferase5
Short name:
Zmet5
Gene namesi
Name:ZMET5
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002466951 – 915DNA (cytosine-5)-methyltransferase 2Add BLAST915

Proteomic databases

PRIDEiQ9ARI6

Expressioni

Gene expression databases

ExpressionAtlasiQ9ARI6 differential

Structurei

3D structure databases

ProteinModelPortaliQ9ARI6
SMRiQ9ARI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 313BAHPROSITE-ProRule annotationAdd BLAST126
Domaini345 – 876SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST532
Domaini445 – 508ChromoPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH5K Eukaryota
COG0270 LUCA
HOGENOMiHOG000082844

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR001025 BAH_dom
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF00385 Chromo, 1 hit
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM00298 CHROMO, 1 hit
SUPFAMiSSF53335 SSF53335, 4 hits
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS00094 C5_MTASE_1, 1 hit
PS50013 CHROMO_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ARI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSSPSSAR PTRASGRERS AMAEEIHQNQ EEEEEVVAAS TAKRRRKAAS
60 70 80 90 100
SGKKPKPTPK QAKPAVAGMK KKGETEKTEP VVDDVCAEEP DEEELAMGEE
110 120 130 140 150
EAEAEEQAMQ EVVAAVAAGS PGKKRVGRRS AAASGDHVPE FIGSPVGAAE
160 170 180 190 200
AHSNWPKRYE RSTAANKPEE DDELKARCHY RSAKVDNIVY CLGDDVYVKA
210 220 230 240 250
GENEADYIGR ITEFFEGTDR CHYFTCRWFF RAEDTVINSL VSINVDGHKH
260 270 280 290 300
DPRRVFLSEE KNDNVLDCII SKVKIVHVDP NMDPKAKAQL IEHCDLYYDM
310 320 330 340 350
SYSVAYSTFA NISSENGQSG SETASGISSD DAGLETSSNM PERTATLLDL
360 370 380 390 400
YSGCGGMSTG LCLGAALSGL KLETRWAVDL NSFACQSLKY NHPQTEVRNE
410 420 430 440 450
KADEFLALLK EWAVLCEKYV HQDVDSNLAG SEDQEDADTL DKDEFVVQKL
460 470 480 490 500
IGIRYDGTGR KKGVYFKVQW EEYGPEEDTW EPIDNLSDCP LKIREFVQEG
510 520 530 540 550
RKRKILPLPG DVDVICGGPP CQGISGFNRF RNRDEPLKDE KNKQMVTFMD
560 570 580 590 600
IVAYLKPKYV LMENVVDILK FADGYLGKYA LSCLVAMKYQ ARLGMMVAGC
610 620 630 640 650
YGLPQFRMRV FLWGALSSMV LPKYPLPTYD VVVRGGAPNA FSQCMVAYDE
660 670 680 690 700
TQRPSLKKAL LLGDAFSDLP KVENHQPNDV MEYGGSPKTE FQRYIRLGRK
710 720 730 740 750
DMLDWSFGEE AGPDEGKLLD HQPLRLNNDD YERVKQIPVK KGANFRDLKG
760 770 780 790 800
VKVGANNVVE WDPEVERVYL SSGKPLVPDY AMSFIKGKSL KPFGRLWWDQ
810 820 830 840 850
TVPTVVTRAE PHNQVILHPT QARVLTIREN ARLQGFPDYY RLFGPIKEKY
860 870 880 890 900
IQVGNAVAVP VARALGYCLG QAYLGESDGS QPLYQLPASF TSVGRTAVQA
910
NAASVGTPAG EVVEQ
Length:915
Mass (Da):101,641
Last modified:June 1, 2001 - v1
Checksum:i4BA29AC625D076B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027539 mRNA Translation: AAK15805.1
UniGeneiZm.161015
Zm.599

Similar proteinsi

Entry informationi

Entry nameiCMT2_MAIZE
AccessioniPrimary (citable) accession number: Q9ARI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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