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Q9ARI6 (CMT2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA (cytosine-5)-methyltransferase 2

EC=2.1.1.37
Alternative name(s):
Chromomethylase 2
DNA cytosine methyltransferase MET5
Zea methyltransferase5
Short name=Zmet5
Gene names
Name:ZMET5
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length915 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the CpXpG methylation and in gene silencing By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 1 BAH domain.

Contains 1 chromo domain.

Contains 1 SAM-dependent MTase C5-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 915915DNA (cytosine-5)-methyltransferase 2
PRO_0000246695

Regions

Domain188 – 313126BAH
Domain345 – 876532SAM-dependent MTase C5-type
Domain445 – 50864Chromo

Sites

Active site5211 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ARI6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4BA29AC625D076B2

FASTA915101,641
        10         20         30         40         50         60 
MAPSSPSSAR PTRASGRERS AMAEEIHQNQ EEEEEVVAAS TAKRRRKAAS SGKKPKPTPK 

        70         80         90        100        110        120 
QAKPAVAGMK KKGETEKTEP VVDDVCAEEP DEEELAMGEE EAEAEEQAMQ EVVAAVAAGS 

       130        140        150        160        170        180 
PGKKRVGRRS AAASGDHVPE FIGSPVGAAE AHSNWPKRYE RSTAANKPEE DDELKARCHY 

       190        200        210        220        230        240 
RSAKVDNIVY CLGDDVYVKA GENEADYIGR ITEFFEGTDR CHYFTCRWFF RAEDTVINSL 

       250        260        270        280        290        300 
VSINVDGHKH DPRRVFLSEE KNDNVLDCII SKVKIVHVDP NMDPKAKAQL IEHCDLYYDM 

       310        320        330        340        350        360 
SYSVAYSTFA NISSENGQSG SETASGISSD DAGLETSSNM PERTATLLDL YSGCGGMSTG 

       370        380        390        400        410        420 
LCLGAALSGL KLETRWAVDL NSFACQSLKY NHPQTEVRNE KADEFLALLK EWAVLCEKYV 

       430        440        450        460        470        480 
HQDVDSNLAG SEDQEDADTL DKDEFVVQKL IGIRYDGTGR KKGVYFKVQW EEYGPEEDTW 

       490        500        510        520        530        540 
EPIDNLSDCP LKIREFVQEG RKRKILPLPG DVDVICGGPP CQGISGFNRF RNRDEPLKDE 

       550        560        570        580        590        600 
KNKQMVTFMD IVAYLKPKYV LMENVVDILK FADGYLGKYA LSCLVAMKYQ ARLGMMVAGC 

       610        620        630        640        650        660 
YGLPQFRMRV FLWGALSSMV LPKYPLPTYD VVVRGGAPNA FSQCMVAYDE TQRPSLKKAL 

       670        680        690        700        710        720 
LLGDAFSDLP KVENHQPNDV MEYGGSPKTE FQRYIRLGRK DMLDWSFGEE AGPDEGKLLD 

       730        740        750        760        770        780 
HQPLRLNNDD YERVKQIPVK KGANFRDLKG VKVGANNVVE WDPEVERVYL SSGKPLVPDY 

       790        800        810        820        830        840 
AMSFIKGKSL KPFGRLWWDQ TVPTVVTRAE PHNQVILHPT QARVLTIREN ARLQGFPDYY 

       850        860        870        880        890        900 
RLFGPIKEKY IQVGNAVAVP VARALGYCLG QAYLGESDGS QPLYQLPASF TSVGRTAVQA 

       910 
NAASVGTPAG EVVEQ 

« Hide

References

[1]"Maize chromomethylase Zea methyltransferase2 is required for CpNpG methylation."
Papa C.M., Springer N.M., Muszynski M.G., Meeley R., Kaeppler S.M.
Plant Cell 13:1919-1928(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY027539 mRNA. Translation: AAK15805.1.
RefSeqNP_001105167.1. NM_001111697.1.
UniGeneZm.599.

3D structure databases

ProteinModelPortalQ9ARI6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE5016. M.ZmaV.

Proteomic databases

PRIDEQ9ARI6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID542060.
KEGGzma:542060.

Organism-specific databases

GrameneQ9ARI6.

Phylogenomic databases

HOGENOMHOG000082844.
KOK00558.

Family and domain databases

InterProIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025821. C5_MeTfrase_pln.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF01426. BAH. 1 hit.
PF00385. Chromo. 1 hit.
PF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSPR00105. C5METTRFRASE.
SMARTSM00439. BAH. 1 hit.
SM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMSSF54160. SSF54160. 1 hit.
PROSITEPS51038. BAH. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCMT2_MAIZE
AccessionPrimary (citable) accession number: Q9ARI6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families