ID   HPPD_SOLSC              Reviewed;         436 AA.
AC   Q9ARF9;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            EC=1.13.11.27;
DE   AltName: Full=4-hydroxyphenylpyruvic acid oxidase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
OS   Solenostemon scutellarioides (Coleus) (Coleus blumei).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae;
OC   Solenostemon.
OX   NCBI_TaxID=4142;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kim K.H.;
RL   Thesis (2001), Philipps-Universitaet Marburg, Germany.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- PATHWAY: Cofactor biosynthesis; prenylquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; AJ309203; CAC37394.1; -; mRNA.
DR   SMR; Q9ARF9; 25-423.
DR   BRENDA; 1.13.11.27; 291502.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    436       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088400.
FT   METAL       213    213       Iron (By similarity).
FT   METAL       295    295       Iron (By similarity).
FT   METAL       381    381       Iron (By similarity).
SQ   SEQUENCE   436 AA;  47736 MW;  663737B7578C0F13 CRC64;
     MGQESTAAAA VVPAEFKLVG HKNFVRSNPM SDHFPVHRFH HVEFWCGDAT NTSRRFSWGL
     GMPLVAKSDL STGNSAHASY LLRSGELSFV FTAPYSPSLA EPSSASIPTF SFSDHRAFTS
     SHGLAVRAVA IQVDSASSAY SAAVSRGAKP VSPPVVLADC ETAIAEVHLY GDTVLRFVSC
     GSGADGWFLP GFEVVGDGVS CQELDYGIRR LDHAVGNVPK LEPVVDYLKK FTGFHEFAEF
     TAEDVGTAES GLNSVVLANN NENVLFPLNE PVYGTKRKSQ IQTYLDHNEG AGVQHLALIT
     EDIFRTLREM RKRSEVGGFE FMPSPPPTYY RNLKSRAGDV LSDEQIEECE KLGILIDRDD
     QGTLLQIFTK PVGDRPTLFI EIIQRVGCMM KDEEGKMYQK GGCGGFGKGN FSELFKSIEE
     YEKMLESKLV TKTAMA
//