Reviewed, UniProtKB/Swiss-Prot Q9ARF9 (HPPD_SOLSC)

Names and origin

Protein names	Recommended name:     4-hydroxyphenylpyruvate dioxygenase     EC=1.13.11.27 Alternative name(s):     4-hydroxyphenylpyruvic acid oxidase       Short name=HPPDase       Short name=4HPPD       Short name=HPD
Organism	Solenostemon scutellarioides (Coleus) (Coleus blumei)
Taxonomic identifier	4142 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Lamiaceae › Nepetoideae › Ocimeae › Solenostemon

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6. Cofactor biosynthesis; prenylquinone biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088400
Sites
	Metal binding	213	1	Iron By similarity
	Metal binding	295	1	Iron By similarity
	Metal binding	381	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ARF9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 663737B7578C0F13	FASTA	436	47,736
	10 20 30 40 50 60 MGQESTAAAA VVPAEFKLVG HKNFVRSNPM SDHFPVHRFH HVEFWCGDAT NTSRRFSWGL 70 80 90 100 110 120 GMPLVAKSDL STGNSAHASY LLRSGELSFV FTAPYSPSLA EPSSASIPTF SFSDHRAFTS 130 140 150 160 170 180 SHGLAVRAVA IQVDSASSAY SAAVSRGAKP VSPPVVLADC ETAIAEVHLY GDTVLRFVSC 190 200 210 220 230 240 GSGADGWFLP GFEVVGDGVS CQELDYGIRR LDHAVGNVPK LEPVVDYLKK FTGFHEFAEF 250 260 270 280 290 300 TAEDVGTAES GLNSVVLANN NENVLFPLNE PVYGTKRKSQ IQTYLDHNEG AGVQHLALIT 310 320 330 340 350 360 EDIFRTLREM RKRSEVGGFE FMPSPPPTYY RNLKSRAGDV LSDEQIEECE KLGILIDRDD 370 380 390 400 410 420 QGTLLQIFTK PVGDRPTLFI EIIQRVGCMM KDEEGKMYQK GGCGGFGKGN FSELFKSIEE 430 YEKMLESKLV TKTAMA

References

[1]	Kim K.H. Thesis (2001), Philipps-Universitaet Marburg, Germany Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ309203 mRNA. Translation: CAC37394.1.
3D structure databases
SMR	Q9ARF9. Positions 25-423.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.13.11.27. 291502.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_SOLSC

Accession

Primary (citable) accession number: Q9ARF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)