Q9AR73 (HQGT_RAUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydroquinone glucosyltransferase
EC=2.4.1.218

Alternative name(s):
Arbutin synthase

Gene names

Name:

AS

Organism

Rauvolfia serpentina (Serpentwood) (Devilpepper)

Taxonomic identifier

4060 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Gentianales › Apocynaceae › Rauvolfioideae › Vinceae › Rauvolfia

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Broad spectrum multifunctional glucosyltransferase. In addition to hydroquinone it accept at least 45 natural and synthetic phenols as well as two cinnamyl alcohols as substrates. Hydroquinone was however the best substrate. In contrast to this broad acceptor substrate specificity, only pyrimidine nucleotide activated glucose is tolerated as a donor substrate.
Catalytic activity	UDP-glucose + hydroquinone = UDP + hydroquinone-O-beta-D-glucopyranoside.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	hydroquinone glucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Hydroquinone glucosyltransferase		PRO_0000074161

Sequences

	Sequence		Length	Mass (Da)
	Q9AR73 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9C1B4A0760321F51	FASTA	470	51,794
	10 20 30 40 50 60 MEHTPHIAMV PTPGMGHLIP LVEFAKRLVL RHNFGVTFII PTDGPLPKAQ KSFLDALPAG 70 80 90 100 110 120 VNYVLLPPVS FDDLPADVRI ETRICLTITR SLPFVRDAVK TLLATTKLAA LVVDLFGTDA 130 140 150 160 170 180 FDVAIEFKVS PYIFYPTTAM CLSLFFHLPK LDQMVSCEYR DVPEPLQIPG CIPIHGKDFL 190 200 210 220 230 240 DPAQDRKNDA YKCLLHQAKR YRLAEGIMVN TFNDLEPGPL KALQEEDQGK PPVYPIGPLI 250 260 270 280 290 300 RADSSSKVDD CECLKWLDDQ PRGSVLFISF GSGGAVSHNQ FIELALGLEM SEQRFLWVVR 310 320 330 340 350 360 SPNDKIANAT YFSIQNQNDA LAYLPEGFLE RTKGRCLLVP SWAPQTEILS HGSTGGFLTH 370 380 390 400 410 420 CGWNSILESV VNGVPLIAWP LYAEQKMNAV MLTEGLKVAL RPKAGENGLI GRVEIANAVK 430 440 450 460 470 GLMEGEEGKK FRSTMKDLKD AASRALSDDG SSTKALAELA CKWENKISST

References

[1]	"Arbutin synthase, a novel member of the NRD1beta glycosyltransferase family, is a unique multifunctional enzyme converting various natural products and xenobiotics." Hefner T., Arend J., Warzecha H., Siems K., Stoeckigt J. Bioorg. Med. Chem. 10:1731-1741(2002) [PubMed: 11937332] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[2]	"Hydroquinone:O-glucosyltransferase from cultivated Rauvolfia cells: enrichment and partial amino acid sequences." Arend J., Warzecha H., Stoeckigt J. Phytochemistry 53:187-193(2000) [PubMed: 10680170] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ310148 mRNA. Translation: CAC35167.1.
3D structure databases
ProteinModelPortal	Q9AR73.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HQGT_RAUSE

Accession

Primary (citable) accession number: Q9AR73

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	June 1, 2001
Last modified:	October 5, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program