ID   Q9AQU4_ORYSJ            Unreviewed;       501 AA.
AC   Q9AQU4;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
GN   Name=GAD {ECO:0000313|EMBL:BAB32870.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947 {ECO:0000313|EMBL:BAB32870.1};
RN   [1] {ECO:0000313|EMBL:BAB32870.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Shoot {ECO:0000313|EMBL:BAB32868.1};
RX   PubMed=11779628; DOI=10.1016/S0167-4781(01)00324-4;
RA   Akama K., Akihiro T., Kitagawa M., Takaiwa F.;
RT   "Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase
RT   that lacks an authentic calmodulin-binding domain at the C-terminus.";
RL   Biochim. Biophys. Acta 1522:143-150(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2;
CC         Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15;
CC         Evidence={ECO:0000256|RuleBase:RU361171};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; AB056060; BAB32868.1; -; mRNA.
DR   EMBL; AB056062; BAB32870.1; -; Genomic_DNA.
DR   RefSeq; XP_015650123.1; XM_015794637.1.
DR   AlphaFoldDB; Q9AQU4; -.
DR   EnsemblPlants; Os08t0465800-03; Os08t0465800-03; Os08g0465800.
DR   GeneID; 4345787; -.
DR   Gramene; Os08t0465800-03; Os08t0465800-03; Os08g0465800.
DR   KEGG; osa:4345787; -.
DR   OrthoDB; 2783360at2759; -.
DR   PlantReactome; R-OSA-1119458; Glutamate degradation.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF37; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   2: Evidence at transcript level;
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382}.
FT   MOD_RES         281
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   501 AA;  56658 MW;  EB4962C147FFA7A8 CRC64;
     MVVSVAATDS DTAQPVQYST FFASRYVRDP LPRFRMPEQS IPREAAYQII NDELMLDGNP
     RLNLASFVTT WMEPECDKLI MDSVNKNYVD MDEYPVTTEL QNRCVNMIAH LFNAPIKEDE
     TAIGVGTVGS SEAIMLAGLA FKRKWQNKRK EQGKPCDKPN IVTGANVQVC WEKFARYFEV
     ELKEVKLSEG YYVMDPVKAV EMVDENTICV AAILGSTLTG EFEDVKLLNN LLTEKNKETG
     WDVPIHVDAA SGGFIAPFLY PELEWDFRLP LVKSINVSGH KYGLVYPGVG WVIWRSKEDL
     PEELIFHINY LGTDQPTFTL NFSKGSSQII AQYYQLIRLG FEGYKNIMQN CMENTAILRE
     GIEATGRFEI LSKEAGVPLV AFSLKDSGRY TVFDISEHLR RFGWIVPAYT MPANAEHVAV
     LRVVIREDFS RSLAERLVSD IVKILHELDA HSAQVLKISS AIAKQQSGDD GVVTKKSVLE
     TEREIFAYWR DQVKKKQTGI C
//