ID   ILVC_BUCUN              Reviewed;         345 AA.
AC   Q9AQ99;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Ketol-acid reductoisomerase;
DE            EC=1.1.1.86;
DE   AltName: Full=Acetohydroxy-acid isomeroreductase;
DE   AltName: Full=Alpha-keto-beta-hydroxylacil reductoisomerase;
DE   Flags: Fragment;
GN   Name=ilvC;
OS   Buchnera aphidicola subsp. Uroleucon sonchi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=118118;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wernegreen J.J., Moran N.A.;
RT   "Accelerated evolutionary rates at biosynthetic loci of Buchnera-
RT   Uroleucon.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
CC       = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
CC   -!- CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate +
CC       NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 2/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 2/4.
CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
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DR   EMBL; AF217554; AAK01025.1; -; Genomic_DNA.
DR   SMR; Q9AQ99; 1-345.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004455; F:ketol-acid reductoisomerase activity; IEA:HAMAP.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00435; -; 1.
DR   InterPro; IPR013023; AcH_isomrdctse.
DR   InterPro; IPR000506; AcH_isomrdctse_C.
DR   InterPro; IPR013116; IlvN.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR21371; AcH_isomrdctse; 1.
DR   Pfam; PF01450; IlvC; 1.
DR   Pfam; PF07991; IlvN; 1.
DR   TIGRFAMs; TIGR00465; ilvC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; NADP;
KW   Oxidoreductase.
FT   CHAIN        <1   >345       Ketol-acid reductoisomerase.
FT                                /FTId=PRO_0000151296.
FT   ACT_SITE     65     65       Potential.
FT   NON_TER       1      1
FT   NON_TER     345    345
SQ   SEQUENCE   345 AA;  39244 MW;  6FE05ABA7849DD03 CRC64;
     KKNSIAKKNQ SWINAIENNF KVDDYESLIP NADLVINLTP DKEHHHVVQV LQKLMKKNSC
     LGYSHGFNIV EFGEIIRKDI TVIMVAPKCP GTEVREEYKR GFGVPTLIAV HNENDIRQIG
     LDIAKAWSFS IGSHRAGVLE SSFIAEVKSD LMGEQTILCG MLQTASLLCY EKLIANKNDP
     AYASKLIQNG WETITESLKH GGITLMMDRL SNASKIRAYN ISEKIKKILS SLFQKHMNDI
     ISGEFSHKMM QDWQNNNKQL LDWRNKNKNT SFEKAPVYHN KIPEQEYYDH GILMIAILKA
     GIELSFETML NSGIIAESAY YESLHELPLI ANTIARKKLY EMNKV
//