Reviewed, UniProtKB/Swiss-Prot Q9AQ96 (ILVC_BUCML)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:

ilvC

Organism

Buchnera aphidicola subsp. Macrosiphoniella ludovicianae

Taxonomic identifier

118105 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	343 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›343	›343	Ketol-acid reductoisomerase		PRO_0000151291
Sites
	Active site	65	1	Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	343	1

Sequences

	Sequence		Length	Mass (Da)
	Q9AQ96-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 67369DC0E240113C	FASTA	343	39,012
	10 20 30 40 50 60 RKNSILKKNQ SWINATKNNF LVGDYESLIP NADLVINLTP DKQHSNVVKE LQKLMKKDAC 70 80 90 100 110 120 LGYSHGFNIV ENGETIRKDI TVIMVAPKCP GTEVREEYKR GFGVPTLIAV HNENDYSNMG 130 140 150 160 170 180 LEVAKAWAFS TGGHRAGVLE SSFVAEVKSD LMGEQTILCG MLQTASLVCY EKLITTQNHP 190 200 210 220 230 240 GYAGKLIQFG WETITESLKH GGITLMMDRL SNSSKIRAFK LSQEIKRIFS KLFQKHMDDI 250 260 270 280 290 300 ISGDFSSKMI QDWKNKDQNL LNWRYKTKNT SFEQSPDYDK KILEQEYYDH GILMVAILKA 310 320 330 340 GIELSFETMI QSGIMEESAY YESLHELPLI ANTIARKKLY EMN

References

[1]	"Accelerated evolutionary rates at biosynthetic loci of Buchnera-Uroleucon." Wernegreen J.J., Moran N.A. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF217557 Genomic DNA. Translation: AAK01028.1.
3D structure databases
SMR	Q9AQ96. Positions 1-343.
ModBase	Search...
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

ILVC_BUCML

Accession

Primary (citable) accession number: Q9AQ96

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 1, 2001
Last modified:	November 4, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)