Reviewed, UniProtKB/Swiss-Prot Q9APY4 (MSRA_CORML)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA
      Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
      Short name=Peptide Met(O) reductase

Gene names

Name:

msrA

Organism

Corynebacterium melassecola

Taxonomic identifier

41643 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Peptide methionine sulfoxide reductase msrA HAMAP MF_01401		PRO_0000138544
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9APY4-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7C2C9B184D1FD18F	FASTA	217	23,891
	10 20 30 40 50 60 MAWFFAPEPV MVTADEALKG GRHTVLENPA PHTVLGTPVT GPWKEGQQRI WIGLGCFWGV 70 80 90 100 110 120 EQMYWQMDGV EGTSVGYAGG FTPNPTYREV CSGRTGHTEI VEVVYDPSKI SLEQLVARGL 130 140 150 160 170 180 EAHDPTQGFR QGNDVGTQYR SAYYTENEEG AARVKAVVDA YGETLKQHGF GEITTEIGVI 190 200 210 SPSEYFLAED YHQQYLDKNP DGYCPHHSTG IPCGVEA

References

[1]	"Cloning of the sodA gene from Corynebacterium melassecola and role of superoxide dismutase in cellular viability." Merkamm M., Guyonvarch A. J. Bacteriol. 183:1284-1295(2001) [PubMed: 11157941] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 17965 / AS B-4821.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF236111 Genomic DNA. Translation: AAK01489.1.
3D structure databases
HSSP	HSSP built from PDB template 1FVG based on UniProtKB P54149.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.8.4.11. 294761.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_CORML

Accession

Primary (citable) accession number: Q9APY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 2001
Last modified:	January 20, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)