Reviewed, UniProtKB/Swiss-Prot Q9ANR7 (TYSY_BACMO)

Names and origin

Protein names

Recommended name:
    Thymidylate synthase A
      Short name=TS A
      Short name=TSase A
    EC=2.1.1.45

Gene names

Name:

thyA

Organism

Bacillus mojavensis

Taxonomic identifier

72360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008
Pathway	Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thymidylate synthase family. Bacterial-type thyA subfamily.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Thymidylate synthase A HAMAP MF_00008		PRO_0000140928
Sites
	Active site	161	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ANR7-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A30F953E928050A6	FASTA	279	32,910
	10 20 30 40 50 60 MTQFDKQYNS IIKEIIKNGI SDEEFDVRTK WESDGTPAHT LSIITKQMRF DNSEVPILTT 70 80 90 100 110 120 KKVAWKTAIK ELLWIWQLKS NDVTELNKMG VHIWDQWKQE DGSIGHAYGF QLAKKNRNLN 130 140 150 160 170 180 GEKVDQVDYL LHQLKNNPSS RRHITMLWNP DELDSMALTP CVYETQWYVK QGKLHLEVRA 190 200 210 220 230 240 RSNDMALGNP FNVFQYNVLQ RMIAQVTGYE LGEYIFNIGD CHVYTRHIDN LKIQMEREQF 250 260 270 EAPKLWINPE VKDFYDFTID DFKLINYKHG DRLSFEVAV

References

[1]	"Related homing endonucleases I-BmoI and I-TevI use different strategies to cleave homologous recognition sites." Edgell D.R., Shub D.A. Proc. Natl. Acad. Sci. U.S.A. 98:7898-7903(2001) [PubMed: 11416170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: s87-18.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF321518 Genomic DNA. Translation: AAK09364.1.
3D structure databases
HSSP	HSSP built from PDB template 1BSP based on UniProtKB P42326.
SMR	Q9ANR7. Positions 2-279.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.45. 295309.
Family and domain databases
HAMAP	MF_00008. [Tree]
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
ProDom	PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_BACMO

Accession

Primary (citable) accession number: Q9ANR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)