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Q9AMR9

- PANC1_BRADU

UniProt

Q9AMR9 - PANC1_BRADU

Protein

Pantothenate synthetase 1

Gene

panC1

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei153 – 1531PantoateUniRule annotation
    Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 378ATPUniRule annotation
    Nucleotide bindingi147 – 1504ATPUniRule annotation
    Nucleotide bindingi184 – 1874ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-2122-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetase 1UniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PS 1UniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligase 1UniRule annotation
    Pantoate-activating enzyme 1UniRule annotation
    Gene namesi
    Name:panC1UniRule annotation
    Ordered Locus Names:blr2102
    ORF Names:id912
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Pantothenate synthetase 1PRO_0000128208Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224911.blr2102.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AMR9.
    SMRiQ9AMR9. Positions 1-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OrthoDBiEOG6Z6FZ4.
    PhylomeDBiQ9AMR9.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9AMR9-1 [UniParc]FASTAAdd to Basket

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    MKVITKVAEL RRALADVRNA EKRIGFVPTM GYLHDGHLAL ISASREHCDV    50
    TVVSIFVNPT QFGPNEDLSR YPRDFARDEA LCGSAGVSII FAPSAEEIYP 100
    AQFESFVEPG ELAKPLCGAF RPGHFRGVAT VVCKLFNMVQ PDVAYFGQKD 150
    FQQCAVIRRM TVDLNLPIEI VTVPTVREPD GLAMSSRNRY LCPEERDRSL 200
    AISRGLFAAA HEFASGERDA ATLIALARRH LERVDRLQYL ELVDPGTLRI 250
    ADSPLRYPAV LCVAAYVGST RLIDNVVLSW SPS 283
    Length:283
    Mass (Da):31,322
    Last modified:June 1, 2001 - v1
    Checksum:iA2CA526734D9A607
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322013 Genomic DNA. Translation: AAG61078.1.
    BA000040 Genomic DNA. Translation: BAC47367.1.
    RefSeqiNP_768742.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC47367; BAC47367; BAC47367.
    GeneIDi1055455.
    KEGGibja:blr2102.
    PATRICi21187544. VBIBraJap65052_2034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF322013 Genomic DNA. Translation: AAG61078.1 .
    BA000040 Genomic DNA. Translation: BAC47367.1 .
    RefSeqi NP_768742.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali Q9AMR9.
    SMRi Q9AMR9. Positions 1-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.blr2102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC47367 ; BAC47367 ; BAC47367 .
    GeneIDi 1055455.
    KEGGi bja:blr2102.
    PATRICi 21187544. VBIBraJap65052_2034.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OrthoDBi EOG6Z6FZ4.
    PhylomeDBi Q9AMR9.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci BJAP224911:GJEJ-2122-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Potential symbiosis-specific genes uncovered by sequencing a 410-kb DNA region of the Bradyrhizobium japonicum chromosome."
      Goettfert M., Roethlisberger S., Kuendig C., Beck C., Marty R., Hennecke H.
      J. Bacteriol. 183:1405-1412(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiPANC1_BRADU
    AccessioniPrimary (citable) accession number: Q9AMR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3