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Q9AMR9

- PANC1_BRADU

UniProt

Q9AMR9 - PANC1_BRADU

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Protein

Pantothenate synthetase 1

Gene

panC1

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei61 – 611Beta-alanineUniRule annotation
Binding sitei61 – 611PantoateUniRule annotation
Binding sitei153 – 1531PantoateUniRule annotation
Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi147 – 1504ATPUniRule annotation
Nucleotide bindingi184 – 1874ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-2122-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 1UniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PS 1UniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligase 1UniRule annotation
Pantoate-activating enzyme 1UniRule annotation
Gene namesi
Name:panC1UniRule annotation
Ordered Locus Names:blr2102
ORF Names:id912
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetase 1PRO_0000128208Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr2102.

Structurei

3D structure databases

ProteinModelPortaliQ9AMR9.
SMRiQ9AMR9. Positions 1-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiQ9AMR9.
KOiK01918.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ9AMR9.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AMR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVITKVAEL RRALADVRNA EKRIGFVPTM GYLHDGHLAL ISASREHCDV
60 70 80 90 100
TVVSIFVNPT QFGPNEDLSR YPRDFARDEA LCGSAGVSII FAPSAEEIYP
110 120 130 140 150
AQFESFVEPG ELAKPLCGAF RPGHFRGVAT VVCKLFNMVQ PDVAYFGQKD
160 170 180 190 200
FQQCAVIRRM TVDLNLPIEI VTVPTVREPD GLAMSSRNRY LCPEERDRSL
210 220 230 240 250
AISRGLFAAA HEFASGERDA ATLIALARRH LERVDRLQYL ELVDPGTLRI
260 270 280
ADSPLRYPAV LCVAAYVGST RLIDNVVLSW SPS
Length:283
Mass (Da):31,322
Last modified:June 1, 2001 - v1
Checksum:iA2CA526734D9A607
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322013 Genomic DNA. Translation: AAG61078.1.
BA000040 Genomic DNA. Translation: BAC47367.1.
RefSeqiNP_768742.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC47367; BAC47367; BAC47367.
GeneIDi1055455.
KEGGibja:blr2102.
PATRICi21187544. VBIBraJap65052_2034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322013 Genomic DNA. Translation: AAG61078.1 .
BA000040 Genomic DNA. Translation: BAC47367.1 .
RefSeqi NP_768742.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q9AMR9.
SMRi Q9AMR9. Positions 1-279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr2102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC47367 ; BAC47367 ; BAC47367 .
GeneIDi 1055455.
KEGGi bja:blr2102.
PATRICi 21187544. VBIBraJap65052_2034.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
InParanoidi Q9AMR9.
KOi K01918.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q9AMR9.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci BJAP224911:GJEJ-2122-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Potential symbiosis-specific genes uncovered by sequencing a 410-kb DNA region of the Bradyrhizobium japonicum chromosome."
    Goettfert M., Roethlisberger S., Kuendig C., Beck C., Marty R., Hennecke H.
    J. Bacteriol. 183:1405-1412(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiPANC1_BRADU
AccessioniPrimary (citable) accession number: Q9AMR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3