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Q9AMR9

- PANC1_BRADU

UniProt

Q9AMR9 - PANC1_BRADU

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Protein
Pantothenate synthetase 1
Gene
panC1, blr2102, id912
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei153 – 1531Pantoate By similarity
Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi147 – 1504ATP By similarity
Nucleotide bindingi184 – 1874ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-2122-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 1 (EC:6.3.2.1)
Short name:
PS 1
Alternative name(s):
Pantoate--beta-alanine ligase 1
Pantoate-activating enzyme 1
Gene namesi
Name:panC1
Ordered Locus Names:blr2102
ORF Names:id912
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetase 1UniRule annotation
PRO_0000128208Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr2102.

Structurei

3D structure databases

ProteinModelPortaliQ9AMR9.
SMRiQ9AMR9. Positions 1-279.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ9AMR9.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AMR9-1 [UniParc]FASTAAdd to Basket

« Hide

MKVITKVAEL RRALADVRNA EKRIGFVPTM GYLHDGHLAL ISASREHCDV    50
TVVSIFVNPT QFGPNEDLSR YPRDFARDEA LCGSAGVSII FAPSAEEIYP 100
AQFESFVEPG ELAKPLCGAF RPGHFRGVAT VVCKLFNMVQ PDVAYFGQKD 150
FQQCAVIRRM TVDLNLPIEI VTVPTVREPD GLAMSSRNRY LCPEERDRSL 200
AISRGLFAAA HEFASGERDA ATLIALARRH LERVDRLQYL ELVDPGTLRI 250
ADSPLRYPAV LCVAAYVGST RLIDNVVLSW SPS 283
Length:283
Mass (Da):31,322
Last modified:June 1, 2001 - v1
Checksum:iA2CA526734D9A607
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322013 Genomic DNA. Translation: AAG61078.1.
BA000040 Genomic DNA. Translation: BAC47367.1.
RefSeqiNP_768742.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC47367; BAC47367; BAC47367.
GeneIDi1055455.
KEGGibja:blr2102.
PATRICi21187544. VBIBraJap65052_2034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF322013 Genomic DNA. Translation: AAG61078.1 .
BA000040 Genomic DNA. Translation: BAC47367.1 .
RefSeqi NP_768742.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q9AMR9.
SMRi Q9AMR9. Positions 1-279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr2102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC47367 ; BAC47367 ; BAC47367 .
GeneIDi 1055455.
KEGGi bja:blr2102.
PATRICi 21187544. VBIBraJap65052_2034.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q9AMR9.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci BJAP224911:GJEJ-2122-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Potential symbiosis-specific genes uncovered by sequencing a 410-kb DNA region of the Bradyrhizobium japonicum chromosome."
    Goettfert M., Roethlisberger S., Kuendig C., Beck C., Marty R., Hennecke H.
    J. Bacteriol. 183:1405-1412(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiPANC1_BRADU
AccessioniPrimary (citable) accession number: Q9AMR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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