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Q9ALM4

- Q9ALM4_9PSEU

UniProt

Q9ALM4 - Q9ALM4_9PSEU

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Protein
Submitted name:

Polyketide synthase extender modules 3-4

Gene

spnC

Organism
Saccharopolyspora spinosa
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1276 – 12761NADP; via carbonyl oxygenImported
Binding sitei1300 – 13001NADPImported
Binding sitei1337 – 13371NADPImported
Binding sitei1366 – 13661NADP; via amide nitrogenImported
Binding sitei1371 – 13711NADP; via amide nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1204 – 12052NADPImported
Nucleotide bindingi1225 – 12273NADPImported
Nucleotide bindingi1254 – 12552NADPImported

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro
  4. phosphopantetheine binding Source: InterPro
  5. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Polyketide synthase extender modules 3-4Imported
Gene namesi
Name:spnCImported
OrganismiSaccharopolyspora spinosaImported
Taxonomic identifieri60894 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IMPX-ray2.57A/B/C/D913-1471[»]
ProteinModelPortaliQ9ALM4.
SMRiQ9ALM4. Positions 4-910, 3000-3090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 2 hits.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMiSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 2 hits.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ALM4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNEEKLREY LRRALVDLHQ ARERLHEAES GEREPIAIVA MGCRYPGGVQ
60 70 80 90 100
DPEGLWKLVA SGGDAIGEFP ADRGWHLDEL YDPDPDQPGT CYTRHGGFLH
110 120 130 140 150
DAGEFDAGFF DISPREALAM DPQQRLLLEI SWETVESAGM DPRSLRGSRT
160 170 180 190 200
GVFAGLMYEG YDTGAHRAGE GVEGYLGTGN AGSVASGRVA YAFGFEGPAV
210 220 230 240 250
TVDTACSSSL VALHLACQSL RQGECDLALA GGVTVMSTPE RFVEFSRQRG
260 270 280 290 300
LAPDGRCKSF AAAADGTGWG EGAGLVLLER LSDARRNGHR VLAVVRGSAV
310 320 330 340 350
NQDGASNGLT APNGLAQERV IQQVLTSAGL SASDVDAVEA HGTGTRLGDP
360 370 380 390 400
IEAQALIAAY GQDRDRDRPL WLGSVKSNIG HTQAAAGVAG VIKMVMAMRH
410 420 430 440 450
GELPRTLHVD EPNSHVDWSA GAVRLLTENI RWPGTGTRRA GVSSFGVSGT
460 470 480 490 500
NAHVILEHDP LAVTENEEAA QSPAPGIVPW ALSGRSSTAL RAQAERLREL
510 520 530 540 550
CEQTDPDPVD VGFSLAATRT AWEHRAVVLG RDSATLRSGL GVVASGEPAV
560 570 580 590 600
DVVEGSVLDG EVVFVFPGQG WQWAGMAVDL LDASPTFARH MDECATALRR
610 620 630 640 650
YVDWSLVDVL RGAENSPPLD RVDVLQPASF AVMVSLAEVW RSYGVRPAAV
660 670 680 690 700
VGHSQGEIAA ACAAGVLPLE DAARLVALRS RALKGLSGRG GMASLACPAD
710 720 730 740 750
EVAALFAGSG GRLEVAAING PRSVVVSGDL EAVDELLAEC AEKDMRARRI
760 770 780 790 800
PVDYASHSAH VEVVRSPVLA AAAGVRHRDG QVPWWSTVIG DWVDPARLDG
810 820 830 840 850
EYWYRNLRQP VRFEHAVQGL VERGFGLFIE MSAHPVLTTA VEETGAESET
860 870 880 890 900
AVAAVGTLRR DSGGLRRLLH SLAEAYVRGA TVDWAVAFGG AGRRLDLPTY
910 920 930 940 950
PFQRQRYWLD KGAASDEARA VSDPAAGWFW QAVARQDLKS VSDALDLDAD
960 970 980 990 1000
APLSATLPAL SVWHRQERER VLADGWRYRV DWVRVAPQPV RRTRETWLLV
1010 1020 1030 1040 1050
VPPGGIEEAL VERLTDALNT RGISTLRLDV PPAATSGELA TELRAAADGD
1060 1070 1080 1090 1100
PVKAILSLTA LDERPHPECK DVPSGIALLL NLVKALGEAD LRIPLWTITR
1110 1120 1130 1140 1150
GAVKAGPADR LLRPMQAQAW GLGRVAALEH PERWGGLIDL PDSLDGDVLT
1160 1170 1180 1190 1200
RLGEALTNGL AEDQLAIRQS GVLARRLVPA PANQPAGRKW RPRGSALITG
1210 1220 1230 1240 1250
GLGAVGAQVA RWLAEIGAER IVLTSRRGNQ AAGAAELEAE LRALGAQVSI
1260 1270 1280 1290 1300
VACDVTDRAE MSALLAEFDV TAVFHAAGVG RLLPLAETDQ NGLAEICAAK
1310 1320 1330 1340 1350
VRGAQVLDEL CDSTDLDAFV LFSSGAGVWG GGGQGAYGAA NAFLDTLAEQ
1360 1370 1380 1390 1400
RRARGLPATS ISWGSWAGGG MADGAAGEHL RRRGIRPMPA ASAILALQEV
1410 1420 1430 1440 1450
LDQDETCVSI ADVDWDRFVP TFAATRATRL FDEVPAARKA MPANGPAEPG
1460 1470 1480 1490 1500
GSPFARNLAE LPEAQRRHEL VDLVCAQVAT VLGHGSREEV QPERAFRALG
1510 1520 1530 1540 1550
FDSLMAVDLR NRLTTATGLR LPTTTVFDYP NPAALAAHLL EELVGDVASA
1560 1570 1580 1590 1600
AVTAASAPAS DEPIAIVAMS CRFPGGAHSP EDLWRLVAAG TEVIGEFPSD
1610 1620 1630 1640 1650
RGWDAEGLYD PDASRPGTTY ARMAGFLYDA GEFDADLFGI SPREALAMDP
1660 1670 1680 1690 1700
QQRLVLEIAW EALERAGIDP LSLKGSGVGT YIGAGSRGYA TDVRQFPEEA
1710 1720 1730 1740 1750
EGYLLTGTSA SVLSGRVAYS FGFEGPAVTV DTACSSSLVA LHLACQSLRS
1760 1770 1780 1790 1800
GECDLALAGG VTVMSTPEMF VEFSRQRGLA PDGRCKSFAE SADGTGWGEG
1810 1820 1830 1840 1850
AGLLLLERLS DAHRNGHRVL AVVRGSAVNQ DGASNGLAAP NGPSQQRVIN
1860 1870 1880 1890 1900
QALANAALSA SDVDAVEAHG TGTRLGDPIE AQALIATYGQ ARERDRPLWL
1910 1920 1930 1940 1950
GSVKSNIGHT QAAAGVAGVI KMVMAMRHGQ LPASLHADEP TSEVDWSSGA
1960 1970 1980 1990 2000
VRLLAEQVPW PESDRVRRVG VSSFGISGTN AHVILEQATN APDSTAETDK
2010 2020 2030 2040 2050
TESGSTVDIP VVPWLVSGKT TDSLRGQAER VLSQVESRPE QRSLDVAYSL
2060 2070 2080 2090 2100
ASGRAALDER AVVLGADRGE LVAGLAALAA GQEASGVISG TRASARFGFV
2110 2120 2130 2140 2150
FSGQGGQWLG MGRALYSKFP VFAAAFDEAC AELEAHLGED RRVRDVVFGS
2160 2170 2180 2190 2200
DAQLLDQTLW AQSGLFALQA GLLGLLGSWG VRPDVVMGHS VGELAAAFAA
2210 2220 2230 2240 2250
GVLSLRDAAR LVAARARLMQ ALPSDGAMLA VAAGEDLVRP LLAGREESVS
2260 2270 2280 2290 2300
VAALNAPGSV VLSGDREVLA SIVGRLTELR VRTRRLRVSH AFHSHRMDPM
2310 2320 2330 2340 2350
LGEFAQIAES AEFGKPTTPL VSTLTGELDR AAEMSTPGYW VRQAREPVRF
2360 2370 2380 2390 2400
ADGVQALAAQ GIGTVVELGP DGTLAALVRE CATESDRVGR ISSIPLMRRE
2410 2420 2430 2440 2450
RDETRSVMTA LAHLHTRGGE VDWQAFFAGT GARQLELPTY AFQRQHYWIE
2460 2470 2480 2490 2500
SSARPARDRA DIGEVAEQFW TAVDQGDLAT LVAALDLGAD DDTCASLSDV
2510 2520 2530 2540 2550
LPALSSWRSG LRNRSLVDSC RYRISWHSSR EVPAPKISGT WLLVVPGAAD
2560 2570 2580 2590 2600
DGLVTALTSS LVGGGAEVVR IGLSEEDPHR EDVAQRLANA LTDAGQLGGV
2610 2620 2630 2640 2650
LSLLGLDESP APGFSCLPTG FALTVQLLRA LRKADVEAPF WAVTRGGVAL
2660 2670 2680 2690 2700
EDVRVSPEQA LVWGLLRVAG LEHPEFWGGL IDLPSDWDDR LGARLAGVLA
2710 2720 2730 2740 2750
DGGEDQVAIR RGGVFVRRLE RAGASGAGSV WRPRGTVLVT GGTGGLGAHV
2760 2770 2780 2790 2800
ARWLAGAGAE HVVLTSRRGA DAPGAGELRA ELEALGARVS IVPCDVADRD
2810 2820 2830 2840 2850
AVAGVLAGIG GECPLTAVVH AAGVGEAGDV VEMGLADFAA VLSAKVRGAA
2860 2870 2880 2890 2900
NLDELLADSE LDAFVMFSSV SGVWGAGGQG AYAAANAYLD ALAEQRRARG
2910 2920 2930 2940 2950
LVGTAVAWGP WAGDGMAAGE TGAQLHRMGL ASMEPSAALL ALQGALDRDE
2960 2970 2980 2990 3000
TSLVVADVDW ARFAPAFTSA RRRPLLDTID EARAALETTG EQAGTGKPVE
3010 3020 3030 3040 3050
LTQRLAGLSR KERDDAVLDL VRAETAAVLG RDDATALAPS RPFQELGFDS
3060 3070 3080 3090 3100
LMAVELRNRL NTATGIQLPA STIFDYPNAE SLSRHLCAEL FPTETTVDSA
3110 3120 3130 3140 3150
LAELDRIEQQ LSMLTGEARA RDRIATRLRA LHEKWNSAAE VPTGADVLST
3160 3170
LDSATHDEIF EFIDNELDLS
Length:3,170
Mass (Da):334,879
Last modified:June 1, 2001 - v1
Checksum:i205D519FDFA3249C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY007564 Genomic DNA. Translation: AAG23266.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY007564 Genomic DNA. Translation: AAG23266.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IMP X-ray 2.57 A/B/C/D 913-1471 [» ]
ProteinModelPortali Q9ALM4.
SMRi Q9ALM4. Positions 4-910, 3000-3090.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 2 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 2 hits.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view ]
SUPFAMi SSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 2 hits.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 2 hits.
PROSITEi PS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa."
    Waldron C., Matsushima P., Rosteck P.R. Jr, Broughton M.C., Turner J., Madduri K., Crawford K.P., Merlo D.J., Baltz R.H.
    Chem. Biol. 8:487-499(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The missing linker: a dimerization motif located within polyketide synthase modules."
    Zheng J., Fage C.D., Demeler B., Hoffman D.W., Keatinge-Clay A.T.
    ACS Chem. Biol. 8:1263-1270(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.57 ANGSTROMS) OF 913-1471 IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ9ALM4_9PSEU
AccessioniPrimary (citable) accession number: Q9ALM4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3