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Q9ALM4

- Q9ALM4_9PSEU

UniProt

Q9ALM4 - Q9ALM4_9PSEU

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Protein
Submitted name:

Polyketide synthase extender modules 3-4

Gene
spnC
Organism
Saccharopolyspora spinosa
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1276 – 12761NADP; via carbonyl oxygenImported
Binding sitei1300 – 13001NADPImported
Binding sitei1337 – 13371NADPImported
Binding sitei1366 – 13661NADP; via amide nitrogenImported
Binding sitei1371 – 13711NADP; via amide nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1204 – 12052NADPImported
Nucleotide bindingi1225 – 12273NADPImported
Nucleotide bindingi1254 – 12552NADPImported

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro
  4. phosphopantetheine binding Source: InterPro
  5. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Polyketide synthase extender modules 3-4Imported
Gene namesi
Name:spnCImported
OrganismiSaccharopolyspora spinosaImported
Taxonomic identifieri60894 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IMPX-ray2.57A/B/C/D913-1471[»]
ProteinModelPortaliQ9ALM4.
SMRiQ9ALM4. Positions 4-910, 3000-3090.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 2 hits.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMiSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 2 hits.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ALM4-1 [UniParc]FASTAAdd to Basket

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MSNEEKLREY LRRALVDLHQ ARERLHEAES GEREPIAIVA MGCRYPGGVQ     50
DPEGLWKLVA SGGDAIGEFP ADRGWHLDEL YDPDPDQPGT CYTRHGGFLH 100
DAGEFDAGFF DISPREALAM DPQQRLLLEI SWETVESAGM DPRSLRGSRT 150
GVFAGLMYEG YDTGAHRAGE GVEGYLGTGN AGSVASGRVA YAFGFEGPAV 200
TVDTACSSSL VALHLACQSL RQGECDLALA GGVTVMSTPE RFVEFSRQRG 250
LAPDGRCKSF AAAADGTGWG EGAGLVLLER LSDARRNGHR VLAVVRGSAV 300
NQDGASNGLT APNGLAQERV IQQVLTSAGL SASDVDAVEA HGTGTRLGDP 350
IEAQALIAAY GQDRDRDRPL WLGSVKSNIG HTQAAAGVAG VIKMVMAMRH 400
GELPRTLHVD EPNSHVDWSA GAVRLLTENI RWPGTGTRRA GVSSFGVSGT 450
NAHVILEHDP LAVTENEEAA QSPAPGIVPW ALSGRSSTAL RAQAERLREL 500
CEQTDPDPVD VGFSLAATRT AWEHRAVVLG RDSATLRSGL GVVASGEPAV 550
DVVEGSVLDG EVVFVFPGQG WQWAGMAVDL LDASPTFARH MDECATALRR 600
YVDWSLVDVL RGAENSPPLD RVDVLQPASF AVMVSLAEVW RSYGVRPAAV 650
VGHSQGEIAA ACAAGVLPLE DAARLVALRS RALKGLSGRG GMASLACPAD 700
EVAALFAGSG GRLEVAAING PRSVVVSGDL EAVDELLAEC AEKDMRARRI 750
PVDYASHSAH VEVVRSPVLA AAAGVRHRDG QVPWWSTVIG DWVDPARLDG 800
EYWYRNLRQP VRFEHAVQGL VERGFGLFIE MSAHPVLTTA VEETGAESET 850
AVAAVGTLRR DSGGLRRLLH SLAEAYVRGA TVDWAVAFGG AGRRLDLPTY 900
PFQRQRYWLD KGAASDEARA VSDPAAGWFW QAVARQDLKS VSDALDLDAD 950
APLSATLPAL SVWHRQERER VLADGWRYRV DWVRVAPQPV RRTRETWLLV 1000
VPPGGIEEAL VERLTDALNT RGISTLRLDV PPAATSGELA TELRAAADGD 1050
PVKAILSLTA LDERPHPECK DVPSGIALLL NLVKALGEAD LRIPLWTITR 1100
GAVKAGPADR LLRPMQAQAW GLGRVAALEH PERWGGLIDL PDSLDGDVLT 1150
RLGEALTNGL AEDQLAIRQS GVLARRLVPA PANQPAGRKW RPRGSALITG 1200
GLGAVGAQVA RWLAEIGAER IVLTSRRGNQ AAGAAELEAE LRALGAQVSI 1250
VACDVTDRAE MSALLAEFDV TAVFHAAGVG RLLPLAETDQ NGLAEICAAK 1300
VRGAQVLDEL CDSTDLDAFV LFSSGAGVWG GGGQGAYGAA NAFLDTLAEQ 1350
RRARGLPATS ISWGSWAGGG MADGAAGEHL RRRGIRPMPA ASAILALQEV 1400
LDQDETCVSI ADVDWDRFVP TFAATRATRL FDEVPAARKA MPANGPAEPG 1450
GSPFARNLAE LPEAQRRHEL VDLVCAQVAT VLGHGSREEV QPERAFRALG 1500
FDSLMAVDLR NRLTTATGLR LPTTTVFDYP NPAALAAHLL EELVGDVASA 1550
AVTAASAPAS DEPIAIVAMS CRFPGGAHSP EDLWRLVAAG TEVIGEFPSD 1600
RGWDAEGLYD PDASRPGTTY ARMAGFLYDA GEFDADLFGI SPREALAMDP 1650
QQRLVLEIAW EALERAGIDP LSLKGSGVGT YIGAGSRGYA TDVRQFPEEA 1700
EGYLLTGTSA SVLSGRVAYS FGFEGPAVTV DTACSSSLVA LHLACQSLRS 1750
GECDLALAGG VTVMSTPEMF VEFSRQRGLA PDGRCKSFAE SADGTGWGEG 1800
AGLLLLERLS DAHRNGHRVL AVVRGSAVNQ DGASNGLAAP NGPSQQRVIN 1850
QALANAALSA SDVDAVEAHG TGTRLGDPIE AQALIATYGQ ARERDRPLWL 1900
GSVKSNIGHT QAAAGVAGVI KMVMAMRHGQ LPASLHADEP TSEVDWSSGA 1950
VRLLAEQVPW PESDRVRRVG VSSFGISGTN AHVILEQATN APDSTAETDK 2000
TESGSTVDIP VVPWLVSGKT TDSLRGQAER VLSQVESRPE QRSLDVAYSL 2050
ASGRAALDER AVVLGADRGE LVAGLAALAA GQEASGVISG TRASARFGFV 2100
FSGQGGQWLG MGRALYSKFP VFAAAFDEAC AELEAHLGED RRVRDVVFGS 2150
DAQLLDQTLW AQSGLFALQA GLLGLLGSWG VRPDVVMGHS VGELAAAFAA 2200
GVLSLRDAAR LVAARARLMQ ALPSDGAMLA VAAGEDLVRP LLAGREESVS 2250
VAALNAPGSV VLSGDREVLA SIVGRLTELR VRTRRLRVSH AFHSHRMDPM 2300
LGEFAQIAES AEFGKPTTPL VSTLTGELDR AAEMSTPGYW VRQAREPVRF 2350
ADGVQALAAQ GIGTVVELGP DGTLAALVRE CATESDRVGR ISSIPLMRRE 2400
RDETRSVMTA LAHLHTRGGE VDWQAFFAGT GARQLELPTY AFQRQHYWIE 2450
SSARPARDRA DIGEVAEQFW TAVDQGDLAT LVAALDLGAD DDTCASLSDV 2500
LPALSSWRSG LRNRSLVDSC RYRISWHSSR EVPAPKISGT WLLVVPGAAD 2550
DGLVTALTSS LVGGGAEVVR IGLSEEDPHR EDVAQRLANA LTDAGQLGGV 2600
LSLLGLDESP APGFSCLPTG FALTVQLLRA LRKADVEAPF WAVTRGGVAL 2650
EDVRVSPEQA LVWGLLRVAG LEHPEFWGGL IDLPSDWDDR LGARLAGVLA 2700
DGGEDQVAIR RGGVFVRRLE RAGASGAGSV WRPRGTVLVT GGTGGLGAHV 2750
ARWLAGAGAE HVVLTSRRGA DAPGAGELRA ELEALGARVS IVPCDVADRD 2800
AVAGVLAGIG GECPLTAVVH AAGVGEAGDV VEMGLADFAA VLSAKVRGAA 2850
NLDELLADSE LDAFVMFSSV SGVWGAGGQG AYAAANAYLD ALAEQRRARG 2900
LVGTAVAWGP WAGDGMAAGE TGAQLHRMGL ASMEPSAALL ALQGALDRDE 2950
TSLVVADVDW ARFAPAFTSA RRRPLLDTID EARAALETTG EQAGTGKPVE 3000
LTQRLAGLSR KERDDAVLDL VRAETAAVLG RDDATALAPS RPFQELGFDS 3050
LMAVELRNRL NTATGIQLPA STIFDYPNAE SLSRHLCAEL FPTETTVDSA 3100
LAELDRIEQQ LSMLTGEARA RDRIATRLRA LHEKWNSAAE VPTGADVLST 3150
LDSATHDEIF EFIDNELDLS 3170
Length:3,170
Mass (Da):334,879
Last modified:June 1, 2001 - v1
Checksum:i205D519FDFA3249C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY007564 Genomic DNA. Translation: AAG23266.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY007564 Genomic DNA. Translation: AAG23266.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IMP X-ray 2.57 A/B/C/D 913-1471 [» ]
ProteinModelPortali Q9ALM4.
SMRi Q9ALM4. Positions 4-910, 3000-3090.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 2 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 2 hits.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view ]
SUPFAMi SSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 2 hits.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 2 hits.
PROSITEi PS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa."
    Waldron C., Matsushima P., Rosteck P.R. Jr, Broughton M.C., Turner J., Madduri K., Crawford K.P., Merlo D.J., Baltz R.H.
    Chem. Biol. 8:487-499(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The missing linker: a dimerization motif located within polyketide synthase modules."
    Zheng J., Fage C.D., Demeler B., Hoffman D.W., Keatinge-Clay A.T.
    ACS Chem. Biol. 8:1263-1270(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.57 ANGSTROMS) OF 913-1471 IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ9ALM4_9PSEU
AccessioniPrimary (citable) accession number: Q9ALM4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi