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Q9ALM4 (Q9ALM4_9PSEU) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:spnC EMBL AAG23266.1
OrganismSaccharopolyspora spinosa EMBL AAG23266.1
Taxonomic identifier60894 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeSaccharopolyspora

Protein attributes

Sequence length3170 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding1204 – 12052NADP PDB 4IMP
Nucleotide binding1225 – 12273NADP PDB 4IMP
Nucleotide binding1254 – 12552NADP PDB 4IMP

Sites

Binding site12761NADP; via carbonyl oxygen PDB 4IMP
Binding site13001NADP PDB 4IMP
Binding site13371NADP PDB 4IMP
Binding site13661NADP; via amide nitrogen PDB 4IMP
Binding site13711NADP; via amide nitrogen PDB 4IMP

Sequences

Sequence LengthMass (Da)Tools
Q9ALM4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 205D519FDFA3249C

FASTA3,170334,879
        10         20         30         40         50         60 
MSNEEKLREY LRRALVDLHQ ARERLHEAES GEREPIAIVA MGCRYPGGVQ DPEGLWKLVA 

        70         80         90        100        110        120 
SGGDAIGEFP ADRGWHLDEL YDPDPDQPGT CYTRHGGFLH DAGEFDAGFF DISPREALAM 

       130        140        150        160        170        180 
DPQQRLLLEI SWETVESAGM DPRSLRGSRT GVFAGLMYEG YDTGAHRAGE GVEGYLGTGN 

       190        200        210        220        230        240 
AGSVASGRVA YAFGFEGPAV TVDTACSSSL VALHLACQSL RQGECDLALA GGVTVMSTPE 

       250        260        270        280        290        300 
RFVEFSRQRG LAPDGRCKSF AAAADGTGWG EGAGLVLLER LSDARRNGHR VLAVVRGSAV 

       310        320        330        340        350        360 
NQDGASNGLT APNGLAQERV IQQVLTSAGL SASDVDAVEA HGTGTRLGDP IEAQALIAAY 

       370        380        390        400        410        420 
GQDRDRDRPL WLGSVKSNIG HTQAAAGVAG VIKMVMAMRH GELPRTLHVD EPNSHVDWSA 

       430        440        450        460        470        480 
GAVRLLTENI RWPGTGTRRA GVSSFGVSGT NAHVILEHDP LAVTENEEAA QSPAPGIVPW 

       490        500        510        520        530        540 
ALSGRSSTAL RAQAERLREL CEQTDPDPVD VGFSLAATRT AWEHRAVVLG RDSATLRSGL 

       550        560        570        580        590        600 
GVVASGEPAV DVVEGSVLDG EVVFVFPGQG WQWAGMAVDL LDASPTFARH MDECATALRR 

       610        620        630        640        650        660 
YVDWSLVDVL RGAENSPPLD RVDVLQPASF AVMVSLAEVW RSYGVRPAAV VGHSQGEIAA 

       670        680        690        700        710        720 
ACAAGVLPLE DAARLVALRS RALKGLSGRG GMASLACPAD EVAALFAGSG GRLEVAAING 

       730        740        750        760        770        780 
PRSVVVSGDL EAVDELLAEC AEKDMRARRI PVDYASHSAH VEVVRSPVLA AAAGVRHRDG 

       790        800        810        820        830        840 
QVPWWSTVIG DWVDPARLDG EYWYRNLRQP VRFEHAVQGL VERGFGLFIE MSAHPVLTTA 

       850        860        870        880        890        900 
VEETGAESET AVAAVGTLRR DSGGLRRLLH SLAEAYVRGA TVDWAVAFGG AGRRLDLPTY 

       910        920        930        940        950        960 
PFQRQRYWLD KGAASDEARA VSDPAAGWFW QAVARQDLKS VSDALDLDAD APLSATLPAL 

       970        980        990       1000       1010       1020 
SVWHRQERER VLADGWRYRV DWVRVAPQPV RRTRETWLLV VPPGGIEEAL VERLTDALNT 

      1030       1040       1050       1060       1070       1080 
RGISTLRLDV PPAATSGELA TELRAAADGD PVKAILSLTA LDERPHPECK DVPSGIALLL 

      1090       1100       1110       1120       1130       1140 
NLVKALGEAD LRIPLWTITR GAVKAGPADR LLRPMQAQAW GLGRVAALEH PERWGGLIDL 

      1150       1160       1170       1180       1190       1200 
PDSLDGDVLT RLGEALTNGL AEDQLAIRQS GVLARRLVPA PANQPAGRKW RPRGSALITG 

      1210       1220       1230       1240       1250       1260 
GLGAVGAQVA RWLAEIGAER IVLTSRRGNQ AAGAAELEAE LRALGAQVSI VACDVTDRAE 

      1270       1280       1290       1300       1310       1320 
MSALLAEFDV TAVFHAAGVG RLLPLAETDQ NGLAEICAAK VRGAQVLDEL CDSTDLDAFV 

      1330       1340       1350       1360       1370       1380 
LFSSGAGVWG GGGQGAYGAA NAFLDTLAEQ RRARGLPATS ISWGSWAGGG MADGAAGEHL 

      1390       1400       1410       1420       1430       1440 
RRRGIRPMPA ASAILALQEV LDQDETCVSI ADVDWDRFVP TFAATRATRL FDEVPAARKA 

      1450       1460       1470       1480       1490       1500 
MPANGPAEPG GSPFARNLAE LPEAQRRHEL VDLVCAQVAT VLGHGSREEV QPERAFRALG 

      1510       1520       1530       1540       1550       1560 
FDSLMAVDLR NRLTTATGLR LPTTTVFDYP NPAALAAHLL EELVGDVASA AVTAASAPAS 

      1570       1580       1590       1600       1610       1620 
DEPIAIVAMS CRFPGGAHSP EDLWRLVAAG TEVIGEFPSD RGWDAEGLYD PDASRPGTTY 

      1630       1640       1650       1660       1670       1680 
ARMAGFLYDA GEFDADLFGI SPREALAMDP QQRLVLEIAW EALERAGIDP LSLKGSGVGT 

      1690       1700       1710       1720       1730       1740 
YIGAGSRGYA TDVRQFPEEA EGYLLTGTSA SVLSGRVAYS FGFEGPAVTV DTACSSSLVA 

      1750       1760       1770       1780       1790       1800 
LHLACQSLRS GECDLALAGG VTVMSTPEMF VEFSRQRGLA PDGRCKSFAE SADGTGWGEG 

      1810       1820       1830       1840       1850       1860 
AGLLLLERLS DAHRNGHRVL AVVRGSAVNQ DGASNGLAAP NGPSQQRVIN QALANAALSA 

      1870       1880       1890       1900       1910       1920 
SDVDAVEAHG TGTRLGDPIE AQALIATYGQ ARERDRPLWL GSVKSNIGHT QAAAGVAGVI 

      1930       1940       1950       1960       1970       1980 
KMVMAMRHGQ LPASLHADEP TSEVDWSSGA VRLLAEQVPW PESDRVRRVG VSSFGISGTN 

      1990       2000       2010       2020       2030       2040 
AHVILEQATN APDSTAETDK TESGSTVDIP VVPWLVSGKT TDSLRGQAER VLSQVESRPE 

      2050       2060       2070       2080       2090       2100 
QRSLDVAYSL ASGRAALDER AVVLGADRGE LVAGLAALAA GQEASGVISG TRASARFGFV 

      2110       2120       2130       2140       2150       2160 
FSGQGGQWLG MGRALYSKFP VFAAAFDEAC AELEAHLGED RRVRDVVFGS DAQLLDQTLW 

      2170       2180       2190       2200       2210       2220 
AQSGLFALQA GLLGLLGSWG VRPDVVMGHS VGELAAAFAA GVLSLRDAAR LVAARARLMQ 

      2230       2240       2250       2260       2270       2280 
ALPSDGAMLA VAAGEDLVRP LLAGREESVS VAALNAPGSV VLSGDREVLA SIVGRLTELR 

      2290       2300       2310       2320       2330       2340 
VRTRRLRVSH AFHSHRMDPM LGEFAQIAES AEFGKPTTPL VSTLTGELDR AAEMSTPGYW 

      2350       2360       2370       2380       2390       2400 
VRQAREPVRF ADGVQALAAQ GIGTVVELGP DGTLAALVRE CATESDRVGR ISSIPLMRRE 

      2410       2420       2430       2440       2450       2460 
RDETRSVMTA LAHLHTRGGE VDWQAFFAGT GARQLELPTY AFQRQHYWIE SSARPARDRA 

      2470       2480       2490       2500       2510       2520 
DIGEVAEQFW TAVDQGDLAT LVAALDLGAD DDTCASLSDV LPALSSWRSG LRNRSLVDSC 

      2530       2540       2550       2560       2570       2580 
RYRISWHSSR EVPAPKISGT WLLVVPGAAD DGLVTALTSS LVGGGAEVVR IGLSEEDPHR 

      2590       2600       2610       2620       2630       2640 
EDVAQRLANA LTDAGQLGGV LSLLGLDESP APGFSCLPTG FALTVQLLRA LRKADVEAPF 

      2650       2660       2670       2680       2690       2700 
WAVTRGGVAL EDVRVSPEQA LVWGLLRVAG LEHPEFWGGL IDLPSDWDDR LGARLAGVLA 

      2710       2720       2730       2740       2750       2760 
DGGEDQVAIR RGGVFVRRLE RAGASGAGSV WRPRGTVLVT GGTGGLGAHV ARWLAGAGAE 

      2770       2780       2790       2800       2810       2820 
HVVLTSRRGA DAPGAGELRA ELEALGARVS IVPCDVADRD AVAGVLAGIG GECPLTAVVH 

      2830       2840       2850       2860       2870       2880 
AAGVGEAGDV VEMGLADFAA VLSAKVRGAA NLDELLADSE LDAFVMFSSV SGVWGAGGQG 

      2890       2900       2910       2920       2930       2940 
AYAAANAYLD ALAEQRRARG LVGTAVAWGP WAGDGMAAGE TGAQLHRMGL ASMEPSAALL 

      2950       2960       2970       2980       2990       3000 
ALQGALDRDE TSLVVADVDW ARFAPAFTSA RRRPLLDTID EARAALETTG EQAGTGKPVE 

      3010       3020       3030       3040       3050       3060 
LTQRLAGLSR KERDDAVLDL VRAETAAVLG RDDATALAPS RPFQELGFDS LMAVELRNRL 

      3070       3080       3090       3100       3110       3120 
NTATGIQLPA STIFDYPNAE SLSRHLCAEL FPTETTVDSA LAELDRIEQQ LSMLTGEARA 

      3130       3140       3150       3160       3170 
RDRIATRLRA LHEKWNSAAE VPTGADVLST LDSATHDEIF EFIDNELDLS 

« Hide

References

[1]"Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa."
Waldron C., Matsushima P., Rosteck P.R. Jr, Broughton M.C., Turner J., Madduri K., Crawford K.P., Merlo D.J., Baltz R.H.
Chem. Biol. 8:487-499(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The missing linker: a dimerization motif located within polyketide synthase modules."
Zheng J., Fage C.D., Demeler B., Hoffman D.W., Keatinge-Clay A.T.
ACS Chem. Biol. 8:1263-1270(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.57 ANGSTROMS) OF 913-1471 IN COMPLEX WITH NADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY007564 Genomic DNA. Translation: AAG23266.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IMPX-ray2.57A/B/C/D913-1471[»]
ProteinModelPortalQ9ALM4.
SMRQ9ALM4. Positions 4-910, 3000-3090.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00698. Acyl_transf_1. 2 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTSM00827. PKS_AT. 2 hits.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 2 hits.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 2 hits.
PROSITEPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9ALM4_9PSEU
AccessionPrimary (citable) accession number: Q9ALM4
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)