Reviewed, UniProtKB/Swiss-Prot Q9AL99 (MSRAB_AGGAC)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA/msrB
Including the following 2 domains:
    1- Recommended name:
            Peptide methionine sulfoxide reductase msrA
                Short name=Protein-methionine-S-oxide reductase
              EC=1.8.4.11
        Alternative name(s):
            Peptide-methionine (S)-S-oxide reductase
              Short name=Peptide Met(O) reductase
    2- Recommended name:
            Peptide methionine sulfoxide reductase msrB
              EC=1.8.4.12
        Alternative name(s):
            Peptide-methionine (R)-S-oxide reductase

Gene names

Name:

msrAB

Organism

Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)

Taxonomic identifier

714 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Aggregatibacter

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01400
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
Sequence similarities	In the N-terminal section; belongs to the msrA Met sulfoxide reductase family. In the C-terminal section; belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Peptide methionine sulfoxide reductase msrA/msrB HAMAP MF_01400		PRO_0000138511
Regions
	Region	46 – 199	154	Peptide methionine sulfoxide reductase A HAMAP MF_01400
	Region	216 – 339	124	Peptide methionine sulfoxide reductase B HAMAP MF_01400
Sites
	Active site	54	1	By similarity
	Active site	328	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9AL99-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 3882FA423CEAE7C7	FASTA	356	40,476
	10 20 30 40 50 60 MKKSKLVVAL AAILSCAAIP TTVMAESNVQ QTMEKSNMSE AKKDLHEIYL AGGCFWGIEA 70 80 90 100 110 120 YMERIYGVED AISGYANGKS DKTNYQKIGI TDHAETVKVT YDRNKVSLDK LLKYYFQVID 130 140 150 160 170 180 PTSVNKQGND RGRQYRTGIY YQDTADKSII EKEITALQGK YKNKIQIEVE PLHNYIVAEE 190 200 210 220 230 240 YHQDYLKKNP NGYCHIDLEQ ANYVIIDEKD YPKPSDAELK AKLTPLQYSV TQNKNTEHSF 250 260 270 280 290 300 SNEYWDNFKP GIYVDVTTGE PLFSSKDKFE SGCGWPSFTK PITKEVVTYQ DDHSFNMLRT 310 320 330 340 350 EVISRSGKAH LGHVFDDGPK DKGGLRYCIN SAAVKFIPLE DMVKENYGYL TNAVKE

References

[1]	"Actinobacillus actinomycetemcomitans msrA." Mintz K.P., Wu H., Shao M., Fives-Taylor P.M. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026361 Genomic DNA. Translation: AAK07680.1.
3D structure databases
SMR	Q9AL99. Positions 211-354.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.8.4.11. 164755. 1.8.4.12. 164755.
Family and domain databases
HAMAP	MF_01400. MsrB. Fused. [Tree] MF_01401. MsrA. Fused. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit. G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRAB_AGGAC

Accession

Primary (citable) accession number: Q9AL99

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)