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Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Rickettsia rickettsii
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha (sucD)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Coenzyme AUniRule annotation1
Binding sitei159Substrate; shared with subunit betaUniRule annotation1
Active sitei248Tele-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit alphaUniRule annotation
Short name:
SCS-alphaUniRule annotation
Gene namesi
Name:sucDUniRule annotationImported
OrganismiRickettsia rickettsiiImported
Taxonomic identifieri783 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 20Coenzyme A bindingUniRule annotation4
Regioni96 – 98Coenzyme A bindingUniRule annotation3

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
HAMAPiMF_01988. Succ_CoA_alpha. 1 hit.
InterProiView protein in InterPro
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR033847. Citrt_syn/SCS-alpha_CS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
PfamiView protein in Pfam
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
SMARTiView protein in SMART
SM00881. CoA_binding. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiView protein in PROSITE
PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AKJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILINKKTQ VICQGFTGLQ GTFHSEQAIA YGTNMVGGVT PGKGGHTHLD
60 70 80 90 100
LPVYNTVHEA KAKTGANASV IYVPPGFAAD SILEAIDAEI EVVVCITEGI
110 120 130 140 150
PVLDMVKVKR ALVGSKTRLI GPNCPGVITP GECKIGIMPG HIHKRGTIGI
160 170 180 190 200
VSRSGTLTYE AVAQTTAVGL GQSTCVGIGG DPVNGTNFVD CIEMFLKDDE
210 220 230 240 250
TKAVIMIGEI GGNAEEDAAE FIKQSKIKKP IVSFIAGITA PPGKRMGHAG
260 270 280 290
AIIVGRTGSA EDKLEALQSA GVVITRSPAD IGKTMLDLLN KG
Length:292
Mass (Da):30,255
Last modified:June 1, 2001 - v1
Checksum:i0ADDABB13E155F3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293311 Genomic DNA. Translation: CAC33660.1.
RefSeqiWP_012150789.1. NZ_CP018914.1.

Similar proteinsi

Entry informationi

Entry nameiQ9AKJ6_RICRI
AccessioniPrimary (citable) accession number: Q9AKJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)