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Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei248 – 2481Tele-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit alpha (EC:6.2.1.5)
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name:
SCS-alpha
Gene namesi
Name:sucD
Ordered Locus Names:RT0419
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Succinate--CoA ligase [ADP-forming] subunit alphaPRO_0000286490Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi257363.RT0419.

Structurei

3D structure databases

ProteinModelPortaliQ9AKE1.
SMRiQ9AKE1. Positions 2-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CH8. Bacteria.
COG0074. LUCA.
HOGENOMiHOG000239685.
KOiK01902.
OMAiVIICITE.
OrthoDBiPOG091H04FK.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9AKE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILINKKTK VICQGFTGSQ GTFHSEQAIA YGTNMVGGVT PGKGGHTHLN
60 70 80 90 100
LPVYNTVHEA KAKTDANASV IYVPPGFAAD SILEAIDAKI EVVVCITEGI
110 120 130 140 150
PVLDMVKVKR ALIGSKTRLI GPNCPGVITP GECKIGIMPG HIHKTGIIGI
160 170 180 190 200
VSRSGTLTYE AVAQTTAVGL GQSTCIGIGG DPVNGTSFVE CIEMFLQDDE
210 220 230 240 250
TKAIIMIGEI GGNAEEDAAD FIKQSKIKKP IVSFIAGITA PSDKRMGHAG
260 270 280 290
AIISGGKGSA KDKLEALQSA GVTITKSPAD IGKTMLDLLN KI
Length:292
Mass (Da):30,250
Last modified:June 1, 2001 - v1
Checksum:i6568C574C91F7500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293310 Genomic DNA. Translation: CAC33725.1.
AE017197 Genomic DNA. Translation: AAU03896.1.
RefSeqiWP_011190880.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03896; AAU03896; RT0419.
KEGGirty:RT0419.
PATRICi17910070. VBIRicTyp34752_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293310 Genomic DNA. Translation: CAC33725.1.
AE017197 Genomic DNA. Translation: AAU03896.1.
RefSeqiWP_011190880.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ9AKE1.
SMRiQ9AKE1. Positions 2-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03896; AAU03896; RT0419.
KEGGirty:RT0419.
PATRICi17910070. VBIRicTyp34752_0447.

Phylogenomic databases

eggNOGiENOG4105CH8. Bacteria.
COG0074. LUCA.
HOGENOMiHOG000239685.
KOiK01902.
OMAiVIICITE.
OrthoDBiPOG091H04FK.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-441-MONOMER.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUCD_RICTY
AccessioniPrimary (citable) accession number: Q9AKE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.