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Q9AK84

- GCSP_STRCO

UniProt

Q9AK84 - GCSP_STRCO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SCO1378
ORF Names:SC10A9.20c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_0000166939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ9AK84.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO1378.

Structurei

3D structure databases

ProteinModelPortaliQ9AK84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiQ9AK84.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ9AK84.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AK84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAHRTPLSE LEQAMPFEQR HIGPDHEARA KMLAQVGYGS LDELTAAAVP
60 70 80 90 100
DVIKNADRLD LPGARSEAEV LAELRSLADR NQVLDSMIGL GYYGTFTPPV
110 120 130 140 150
ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTMVAEL TGLPTSGASL
160 170 180 190 200
LDEGTAAAEA MALSRRMGKN KKGLFLVDAD ALPQTVAVIR TRAEPTGVEV
210 220 230 240 250
VVADLSEGIP AEVAEREING VLLQYPGASG AVRDIKPVID RAHELGALVT
260 270 280 290 300
VAADLLALTL LTSPGELGAD IAVGTTQRFG VPMGFGGPHA GYMAVHEKFA
310 320 330 340 350
RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM
360 370 380 390 400
AGMYAVYHGP EGLRAIARRT HRYATITAAG LAAGGVEIVH GSYFDTVTAR
410 420 430 440 450
VPGRAAGIVH AARENGINLR LVDADHVSFA CDETTTRAQV GGVWHAFGVE
460 470 480 490 500
GDIESLDAEA GETLPEALLR TDDFLTHPVF HQHRSETAML RYLRRLADRD
510 520 530 540 550
YALDRGMIPL GSCTMKLNAT TEMEPVTWPE FGALHPFAPA EQAQGYLTLI
560 570 580 590 600
RELEERLAEV TGYDKVSLQP NAGSQGEFAG LLAVRGYHRA NGDEQRTVCL
610 620 630 640 650
IPSSAHGTNA ASAVMAGMKV VVVKTAEDGE IDVEDLRAKI DKHRDELAVL
660 670 680 690 700
MITYPSTHGV FEEHVADICA QVHDAGGQVY VDGANLNALV GLAKPGHFGG
710 720 730 740 750
DVSHLNLHKT FCIPHGGGGP GVGPVGVRSH LAPYLPNHPL QPAAGPQTGV
760 770 780 790 800
GPISAAPWGS AGILPISWSY VRLMGGEGLK RATQVAVLSA NYIAKRLEPH
810 820 830 840 850
FPVLYNGPGG LVAHECIIDL RPLTKATGVS VDDVAKRLID YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESEDLAELD RFCEAMIAIR AEIEKVGSGA WPADDNPLRG
910 920 930 940 950
APHTADALGG EWDHAYTREE AVFPAGVSAA DKYWPPVRRI DQAYGDRNLV
960
CSCPPLDAYE D
Length:961
Mass (Da):102,809
Last modified:June 1, 2001 - v1
Checksum:i7A9D905DD1E6D3D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939108 Genomic DNA. Translation: CAC32302.1.
RefSeqiNP_625662.1. NC_003888.3.
WP_011027754.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC32302; CAC32302; CAC32302.
GeneIDi1096801.
KEGGisco:SCO1378.
PATRICi23732324. VBIStrCoe124346_1386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939108 Genomic DNA. Translation: CAC32302.1 .
RefSeqi NP_625662.1. NC_003888.3.
WP_011027754.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9AK84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1378.

Proteomic databases

PRIDEi Q9AK84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC32302 ; CAC32302 ; CAC32302 .
GeneIDi 1096801.
KEGGi sco:SCO1378.
PATRICi 23732324. VBIStrCoe124346_1386.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
InParanoidi Q9AK84.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q9AK84.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiGCSP_STRCO
AccessioniPrimary (citable) accession number: Q9AK84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3