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Q9AK84

- GCSP_STRCO

UniProt

Q9AK84 - GCSP_STRCO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, SCO1378, SC10A9.20c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:SCO1378
ORF Names:SC10A9.20c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ9AK84.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi100226.SCO1378.

Structurei

3D structure databases

ProteinModelPortaliQ9AK84.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ9AK84.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AK84-1 [UniParc]FASTAAdd to Basket

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MTAHRTPLSE LEQAMPFEQR HIGPDHEARA KMLAQVGYGS LDELTAAAVP    50
DVIKNADRLD LPGARSEAEV LAELRSLADR NQVLDSMIGL GYYGTFTPPV 100
ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTMVAEL TGLPTSGASL 150
LDEGTAAAEA MALSRRMGKN KKGLFLVDAD ALPQTVAVIR TRAEPTGVEV 200
VVADLSEGIP AEVAEREING VLLQYPGASG AVRDIKPVID RAHELGALVT 250
VAADLLALTL LTSPGELGAD IAVGTTQRFG VPMGFGGPHA GYMAVHEKFA 300
RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM 350
AGMYAVYHGP EGLRAIARRT HRYATITAAG LAAGGVEIVH GSYFDTVTAR 400
VPGRAAGIVH AARENGINLR LVDADHVSFA CDETTTRAQV GGVWHAFGVE 450
GDIESLDAEA GETLPEALLR TDDFLTHPVF HQHRSETAML RYLRRLADRD 500
YALDRGMIPL GSCTMKLNAT TEMEPVTWPE FGALHPFAPA EQAQGYLTLI 550
RELEERLAEV TGYDKVSLQP NAGSQGEFAG LLAVRGYHRA NGDEQRTVCL 600
IPSSAHGTNA ASAVMAGMKV VVVKTAEDGE IDVEDLRAKI DKHRDELAVL 650
MITYPSTHGV FEEHVADICA QVHDAGGQVY VDGANLNALV GLAKPGHFGG 700
DVSHLNLHKT FCIPHGGGGP GVGPVGVRSH LAPYLPNHPL QPAAGPQTGV 750
GPISAAPWGS AGILPISWSY VRLMGGEGLK RATQVAVLSA NYIAKRLEPH 800
FPVLYNGPGG LVAHECIIDL RPLTKATGVS VDDVAKRLID YGFHAPTMSF 850
PVAGTLMIEP TESEDLAELD RFCEAMIAIR AEIEKVGSGA WPADDNPLRG 900
APHTADALGG EWDHAYTREE AVFPAGVSAA DKYWPPVRRI DQAYGDRNLV 950
CSCPPLDAYE D 961
Length:961
Mass (Da):102,809
Last modified:June 1, 2001 - v1
Checksum:i7A9D905DD1E6D3D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939108 Genomic DNA. Translation: CAC32302.1.
RefSeqiNP_625662.1. NC_003888.3.
WP_011027754.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC32302; CAC32302; CAC32302.
GeneIDi1096801.
KEGGisco:SCO1378.
PATRICi23732324. VBIStrCoe124346_1386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939108 Genomic DNA. Translation: CAC32302.1 .
RefSeqi NP_625662.1. NC_003888.3.
WP_011027754.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9AK84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1378.

Proteomic databases

PRIDEi Q9AK84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC32302 ; CAC32302 ; CAC32302 .
GeneIDi 1096801.
KEGGi sco:SCO1378.
PATRICi 23732324. VBIStrCoe124346_1386.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q9AK84.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiGCSP_STRCO
AccessioniPrimary (citable) accession number: Q9AK84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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