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Q9AK84

- GCSP_STRCO

UniProt

Q9AK84 - GCSP_STRCO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:SCO1378
    ORF Names:SC10A9.20c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_0000166939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ9AK84.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi100226.SCO1378.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AK84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.
    PhylomeDBiQ9AK84.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9AK84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAHRTPLSE LEQAMPFEQR HIGPDHEARA KMLAQVGYGS LDELTAAAVP    50
    DVIKNADRLD LPGARSEAEV LAELRSLADR NQVLDSMIGL GYYGTFTPPV 100
    ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTMVAEL TGLPTSGASL 150
    LDEGTAAAEA MALSRRMGKN KKGLFLVDAD ALPQTVAVIR TRAEPTGVEV 200
    VVADLSEGIP AEVAEREING VLLQYPGASG AVRDIKPVID RAHELGALVT 250
    VAADLLALTL LTSPGELGAD IAVGTTQRFG VPMGFGGPHA GYMAVHEKFA 300
    RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM 350
    AGMYAVYHGP EGLRAIARRT HRYATITAAG LAAGGVEIVH GSYFDTVTAR 400
    VPGRAAGIVH AARENGINLR LVDADHVSFA CDETTTRAQV GGVWHAFGVE 450
    GDIESLDAEA GETLPEALLR TDDFLTHPVF HQHRSETAML RYLRRLADRD 500
    YALDRGMIPL GSCTMKLNAT TEMEPVTWPE FGALHPFAPA EQAQGYLTLI 550
    RELEERLAEV TGYDKVSLQP NAGSQGEFAG LLAVRGYHRA NGDEQRTVCL 600
    IPSSAHGTNA ASAVMAGMKV VVVKTAEDGE IDVEDLRAKI DKHRDELAVL 650
    MITYPSTHGV FEEHVADICA QVHDAGGQVY VDGANLNALV GLAKPGHFGG 700
    DVSHLNLHKT FCIPHGGGGP GVGPVGVRSH LAPYLPNHPL QPAAGPQTGV 750
    GPISAAPWGS AGILPISWSY VRLMGGEGLK RATQVAVLSA NYIAKRLEPH 800
    FPVLYNGPGG LVAHECIIDL RPLTKATGVS VDDVAKRLID YGFHAPTMSF 850
    PVAGTLMIEP TESEDLAELD RFCEAMIAIR AEIEKVGSGA WPADDNPLRG 900
    APHTADALGG EWDHAYTREE AVFPAGVSAA DKYWPPVRRI DQAYGDRNLV 950
    CSCPPLDAYE D 961
    Length:961
    Mass (Da):102,809
    Last modified:June 1, 2001 - v1
    Checksum:i7A9D905DD1E6D3D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939108 Genomic DNA. Translation: CAC32302.1.
    RefSeqiNP_625662.1. NC_003888.3.
    WP_011027754.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAC32302; CAC32302; CAC32302.
    GeneIDi1096801.
    KEGGisco:SCO1378.
    PATRICi23732324. VBIStrCoe124346_1386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939108 Genomic DNA. Translation: CAC32302.1 .
    RefSeqi NP_625662.1. NC_003888.3.
    WP_011027754.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9AK84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO1378.

    Proteomic databases

    PRIDEi Q9AK84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC32302 ; CAC32302 ; CAC32302 .
    GeneIDi 1096801.
    KEGGi sco:SCO1378.
    PATRICi 23732324. VBIStrCoe124346_1386.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.
    PhylomeDBi Q9AK84.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiGCSP_STRCO
    AccessioniPrimary (citable) accession number: Q9AK84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3