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Q9AK84 (GCSP_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:SCO1378
ORF Names:SC10A9.20c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 961961Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166939

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9AK84 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7A9D905DD1E6D3D5

FASTA961102,809
        10         20         30         40         50         60 
MTAHRTPLSE LEQAMPFEQR HIGPDHEARA KMLAQVGYGS LDELTAAAVP DVIKNADRLD 

        70         80         90        100        110        120 
LPGARSEAEV LAELRSLADR NQVLDSMIGL GYYGTFTPPV ILRNVMENPA WYTAYTPYQP 

       130        140        150        160        170        180 
EISQGRLEAL LNFQTMVAEL TGLPTSGASL LDEGTAAAEA MALSRRMGKN KKGLFLVDAD 

       190        200        210        220        230        240 
ALPQTVAVIR TRAEPTGVEV VVADLSEGIP AEVAEREING VLLQYPGASG AVRDIKPVID 

       250        260        270        280        290        300 
RAHELGALVT VAADLLALTL LTSPGELGAD IAVGTTQRFG VPMGFGGPHA GYMAVHEKFA 

       310        320        330        340        350        360 
RSLPGRLVGV SVDADGNKAY RLALQTREQH IRREKATSNI CTAQVLLAVM AGMYAVYHGP 

       370        380        390        400        410        420 
EGLRAIARRT HRYATITAAG LAAGGVEIVH GSYFDTVTAR VPGRAAGIVH AARENGINLR 

       430        440        450        460        470        480 
LVDADHVSFA CDETTTRAQV GGVWHAFGVE GDIESLDAEA GETLPEALLR TDDFLTHPVF 

       490        500        510        520        530        540 
HQHRSETAML RYLRRLADRD YALDRGMIPL GSCTMKLNAT TEMEPVTWPE FGALHPFAPA 

       550        560        570        580        590        600 
EQAQGYLTLI RELEERLAEV TGYDKVSLQP NAGSQGEFAG LLAVRGYHRA NGDEQRTVCL 

       610        620        630        640        650        660 
IPSSAHGTNA ASAVMAGMKV VVVKTAEDGE IDVEDLRAKI DKHRDELAVL MITYPSTHGV 

       670        680        690        700        710        720 
FEEHVADICA QVHDAGGQVY VDGANLNALV GLAKPGHFGG DVSHLNLHKT FCIPHGGGGP 

       730        740        750        760        770        780 
GVGPVGVRSH LAPYLPNHPL QPAAGPQTGV GPISAAPWGS AGILPISWSY VRLMGGEGLK 

       790        800        810        820        830        840 
RATQVAVLSA NYIAKRLEPH FPVLYNGPGG LVAHECIIDL RPLTKATGVS VDDVAKRLID 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESEDLAELD RFCEAMIAIR AEIEKVGSGA WPADDNPLRG 

       910        920        930        940        950        960 
APHTADALGG EWDHAYTREE AVFPAGVSAA DKYWPPVRRI DQAYGDRNLV CSCPPLDAYE 


D 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939108 Genomic DNA. Translation: CAC32302.1.
RefSeqNP_625662.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9AK84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO1378.

Proteomic databases

PRIDEQ9AK84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC32302; CAC32302; CAC32302.
GeneID1096801.
KEGGsco:SCO1378.
PATRIC23732324. VBIStrCoe124346_1386.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
PhylomeDBQ9AK84.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_STRCO
AccessionPrimary (citable) accession number: Q9AK84
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families