Reviewed, UniProtKB/Swiss-Prot Q9AK25 (ADD5_STRCO)

Names and origin

Protein names

Recommended name:
    Probable adenosine deaminase 5
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase 5

Gene names

Name:	add5
Ordered Locus Names:	SCO4901
ORF Names:	2SCK8.27

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Probable adenosine deaminase 5 HAMAP MF_00540		PRO_0000194391
Sites
	Active site	224	1	Potential
	Active site	283	1	Potential
	Active site	316	1	Potential
	Active site	317	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9AK25-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5426A20DAB5F929E	FASTA	396	43,961
	10 20 30 40 50 60 MTSRSTEKSA AANPAAVSKT PSPDRIRRAP KVLLHDHLDG GLRPGTIVEL ARETGYGDLP 70 80 90 100 110 120 ETDADLLGTW FRQAADSGSL ERYLETFSHT VGVMQTRDAL VRVAAECAED LAEDGVVYAE 130 140 150 160 170 180 VRYAPEQHLE KGLTLEEVVE AVNEGFREGE RRARDNGHRI RVGALLTAMR HAARSLEIAE 190 200 210 220 230 240 LANRYRDLGV VGFDIAGAEA GYPPTRHLDA FEYLKRENNH FTIHAGEAFG LPSIWQALQW 250 260 270 280 290 300 CGADRLGHGV RIIDDIQVHE DGSVKLGRLA SYVRDKRIPL ELCPSSNLQT GAADSYAEHP 310 320 330 340 350 360 IGLLRRLHFR ATVNTDNRLM SHTSMSREFE HLVEAFGYTL DDMQWFSVNA MKSAFIPFDE 370 380 390 RLAMINDVIK PGYAELKSEW LFQQTASTSG SSESDG

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939121 Genomic DNA. Translation: CAC33066.1.
RefSeq	NP_629054.1.
3D structure databases
HSSP	HSSP built from PDB template 1KRM based on UniProtKB P56658.
ModBase	Search...
Genome annotation databases
GeneID	1100342.
GenomeReviews	Gene locus SCO4901 in contig AL645882_GR.
KEGG	sco:SCO4901.
NMPDR	fig|100226.1.peg.4856.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9AK25.
OMA	FLKKLDW.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO4901-MON.
BRENDA	3.5.4.4. 1084.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD5_STRCO

Accession

Primary (citable) accession number: Q9AK25

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)