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Protein
Submitted name:

EscU

Gene

escU

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DioxygenaseImported, IsomeraseImported, Oxidoreductase

Names & Taxonomyi

Protein namesi
Submitted name:
EscUImported
Submitted name:
EscU proteinImported
Submitted name:
Secretion proteinImported
Submitted name:
T3SS structure protein EscUImported
Gene namesi
Name:escUImported
ORF Names:ACU79_01790Imported, ERS085366_03377Imported, UN86_14425Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000033592 Componenti: Unassembled WGS sequence
  • UP000045242 Componenti: Unassembled WGS sequence
  • UP000050532 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei67 – 8620HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15626HelicalSequence analysisAdd
BLAST
Transmembranei176 – 20429HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5132.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BZLX-ray1.71A/B215-262[»]
C/D263-345[»]
3BZOX-ray1.50A215-262[»]
B263-345[»]
3BZPX-ray1.50A215-345[»]
3BZRX-ray1.65A215-345[»]
3BZSX-ray1.48A215-345[»]
3BZTX-ray1.50A215-345[»]
3BZVX-ray1.94A215-262[»]
B263-345[»]
3BZXX-ray1.60A215-262[»]
B263-345[»]
3BZYX-ray1.20A215-262[»]
B263-345[»]
3BZZX-ray1.41A215-262[»]
B263-345[»]
3C00X-ray1.41A215-262[»]
B263-345[»]
3C03X-ray1.90A215-345[»]
B215-262[»]
C263-345[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4108IUF. Bacteria.
COG4792. LUCA.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006307. BsaZ.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR01404. FlhB_rel_III. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AJ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKTEKPTP KKLRDLKKKG DVTKSEEVMA AVQSLILFSF FSLYGASFFV
60 70 80 90 100
EVVELVNTTI DSLNRPFLYA IREILGAVLN IFLLYILPIS LIVFVGTVTT
110 120 130 140 150
GVSQTGFIFA VEKIKPSAQK ISVKNNLKNI FSVKSIFELL KSVFKLVIIT
160 170 180 190 200
LIFYFMGHSY ANEFANFTRL NAYQTLVVVA FFVFLLWKGV LFGYLLFSVF
210 220 230 240 250
DFWFQKHEGL KKMKMSKDEV KREAKDTDGN PEIKGERRRL HSEIQSGSLA
260 270 280 290 300
NNIKKSTVIV KNPTHIAICL YYKLGETPLP LVIETGKDAK ALQIIKLAEL
310 320 330 340
YDIPVIEDIP LARSLYKNIH KGQYITEDFF EPVAQLIRIA IDLDY
Length:345
Mass (Da):39,308
Last modified:June 1, 2001 - v1
Checksum:i4B74D556189ECC09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200363 Genomic DNA. Translation: AAK26703.1.
AF453441 Genomic DNA. Translation: AAL57530.1.
AJ303141 Genomic DNA. Translation: CAI43886.1.
FM201463 Genomic DNA. Translation: CAR47969.1.
FM201464 Genomic DNA. Translation: CAR48039.1.
CYAV01000042 Genomic DNA. Translation: CTT38652.1.
JZDU01000078 Genomic DNA. Translation: KJW32479.1.
LECM01000013 Genomic DNA. Translation: KPO63848.1.
RefSeqiWP_001291686.1. NZ_LPZK01000057.1.

Genome annotation databases

EnsemblBacteriaiCTT38652; CTT38652; ERS085366_03377.
CTT49769; CTT49769; ERS085359_03460.
CTV26137; CTV26137; ERS139207_00909.
CTV60954; CTV60954; ERS085421_01983.
CTV75051; CTV75051; ERS085427_01785.
CTV84077; CTV84077; ERS085398_04386.
CTW36126; CTW36126; ERS085397_04411.
CTW39364; CTW39364; ERS085399_04184.
CTW43996; CTW43996; ERS139219_04393.
CTX74787; CTX74787; ERS139236_04216.
CTZ68273; CTZ68273; ERS139205_04182.
CTZ92255; CTZ92255; ERS150879_03376.
KJW32479; KJW32479; UN86_14425.
KJY12961; KJY12961; UC21_03660.
KLG39975; KLG39975; WQ92_20055.
KLG92170; KLG92170; WR05_11470.
KLG98356; KLG98356; WR03_13065.
KLH10316; KLH10316; WQ88_04160.
KLH35930; KLH35930; WQ96_09555.
KNF49700; KNF49700; WQ76_24265.
KNF59417; KNF59417; WQ98_10030.
KNF81696; KNF81696; WQ78_25355.
KNF98892; KNF98892; WQ80_20235.
KNZ23836; KNZ23836; AGA32_23435.
KPO63848; KPO63848; ACU79_01790.
KPO99175; KPO99175; ACU88_09580.
KPP04655; KPP04655; ACU83_03650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200363 Genomic DNA. Translation: AAK26703.1.
AF453441 Genomic DNA. Translation: AAL57530.1.
AJ303141 Genomic DNA. Translation: CAI43886.1.
FM201463 Genomic DNA. Translation: CAR47969.1.
FM201464 Genomic DNA. Translation: CAR48039.1.
CYAV01000042 Genomic DNA. Translation: CTT38652.1.
JZDU01000078 Genomic DNA. Translation: KJW32479.1.
LECM01000013 Genomic DNA. Translation: KPO63848.1.
RefSeqiWP_001291686.1. NZ_LPZK01000057.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BZLX-ray1.71A/B215-262[»]
C/D263-345[»]
3BZOX-ray1.50A215-262[»]
B263-345[»]
3BZPX-ray1.50A215-345[»]
3BZRX-ray1.65A215-345[»]
3BZSX-ray1.48A215-345[»]
3BZTX-ray1.50A215-345[»]
3BZVX-ray1.94A215-262[»]
B263-345[»]
3BZXX-ray1.60A215-262[»]
B263-345[»]
3BZYX-ray1.20A215-262[»]
B263-345[»]
3BZZX-ray1.41A215-262[»]
B263-345[»]
3C00X-ray1.41A215-262[»]
B263-345[»]
3C03X-ray1.90A215-345[»]
B215-262[»]
C263-345[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z5132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCTT38652; CTT38652; ERS085366_03377.
CTT49769; CTT49769; ERS085359_03460.
CTV26137; CTV26137; ERS139207_00909.
CTV60954; CTV60954; ERS085421_01983.
CTV75051; CTV75051; ERS085427_01785.
CTV84077; CTV84077; ERS085398_04386.
CTW36126; CTW36126; ERS085397_04411.
CTW39364; CTW39364; ERS085399_04184.
CTW43996; CTW43996; ERS139219_04393.
CTX74787; CTX74787; ERS139236_04216.
CTZ68273; CTZ68273; ERS139205_04182.
CTZ92255; CTZ92255; ERS150879_03376.
KJW32479; KJW32479; UN86_14425.
KJY12961; KJY12961; UC21_03660.
KLG39975; KLG39975; WQ92_20055.
KLG92170; KLG92170; WR05_11470.
KLG98356; KLG98356; WR03_13065.
KLH10316; KLH10316; WQ88_04160.
KLH35930; KLH35930; WQ96_09555.
KNF49700; KNF49700; WQ76_24265.
KNF59417; KNF59417; WQ98_10030.
KNF81696; KNF81696; WQ78_25355.
KNF98892; KNF98892; WQ80_20235.
KNZ23836; KNZ23836; AGA32_23435.
KPO63848; KPO63848; ACU79_01790.
KPO99175; KPO99175; ACU88_09580.
KPP04655; KPP04655; ACU83_03650.

Phylogenomic databases

eggNOGiENOG4108IUF. Bacteria.
COG4792. LUCA.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006307. BsaZ.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR01404. FlhB_rel_III. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69."
    Elliott S.J., Wainwright L.A., McDaniel T.K., Jarvis K.G., Deng Y.K., Lai L.C., McNamara B.P., Donnenberg M.S., Kaper J.B.
    Mol. Microbiol. 28:1-4(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RDEC-1Imported.
  2. "Identification of a new pathogenicity island inserted in the pheV tRNA gene of the bovine Shiga toxin-producing E. coli strain RW1374 (O103:H2) harboring a locus of enterocyte effacement that is flanked by intact insertion elements."
    Jores J., Rumer L., Kiessling S., Kaper J.B., Wieler L.H.
    FEMS Microbiol. Lett. 204:75-79(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RW1374Imported.
  3. "Complete nucleotide sequence and analysis of the locus of enterocyte effacement from rabbit diarrheagenic Escherichia coli RDEC-1."
    Zhu C., Agin T.S., Elliott S.J., Johnson L.A., Thate T.E., Kaper J.B., Boedeker E.C.
    Infect. Immun. 69:2107-2115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RDEC-1Imported.
  4. "Characterization and evidence of mobilization of the LEE pathogenicity island of rabbit-specific strains of enteropathogenic Escherichia coli."
    Tauschek M., Strugnell R.A., Robins-Browne R.M.
    Mol. Microbiol. 44:1533-1550(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 83/39Imported.
  5. "Dissemination of pheU- and pheV-located genomic islands among enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli and their possible role in the horizontal transfer of the locus of enterocyte effacement (LEE)."
    Rumer L., Jores J., Kirsch P., Cavignac Y., Zehmke K., Wieler L.H.
    Int. J. Med. Microbiol. 292:463-475(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RW1374Imported.
  6. "Description of a 111-kb pathogenicity island (PAI) encoding various virulence features in the enterohemorrhagic E. coli (EHEC) strain RW1374 (O103:H2) and detection of a similar PAI in other EHEC strains of serotype 0103:H2."
    Jores J., Wagner S.K., Rumer L., Eichberg J., Laturnus C., Kirsch P., Schierack P., Tschaepe H., Wieler L.H.
    Int. J. Med. Microbiol. 294:417-425(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RW1374Imported.
  7. "Plastizitaet bakterieller Genome: Praevalenz bedeutender Virulenzfaktoren intestinalpathogener Escherichia coli."
    Mueller D.
    Thesis (2006), Department of Biology, University of Muenster, Muenster, Germany
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 9812Imported and B6Imported.
  8. "Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS."
    Zarivach R., Deng W., Vuckovic M., Felise H.B., Nguyen H.V., Miller S.I., Finlay B.B., Strynadka N.C.
    Nature 453:124-127(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 215-262 AND 263-345.
  9. "Comparative analysis of the locus of enterocyte effacement and its flanking regions."
    Muller D., Benz I., Liebchen A., Gallitz I., Karch H., Schmidt M.A.
    Infect. Immun. 77:3501-3513(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 9812Imported and B6Imported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 05-6545Imported.
  11. "Genome sequences of 11 non-O157 Shiga Toxin-Producing Escherichia coli strains."
    Gabrielsen C., Afset J.E., Drablos F.
    Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: St. Olav39Imported.
  12. "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal Agent of Kiwifruit Canker Disease."
    Rikkerink E.H.A., Fineran P.C.
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 503225_aEPECImported.
  13. Pathogen Informatics
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 503225_aEPECImported.

Entry informationi

Entry nameiQ9AJ26_ECOLX
AccessioniPrimary (citable) accession number: Q9AJ26
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.