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Q9AHK1

- LUXS_VIBVU

UniProt

Q9AHK1 - LUXS_VIBVU

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Protein
S-ribosylhomocysteine lyase
Gene
luxS, VV1_1608
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Iron By similarity
Metal bindingi58 – 581Iron By similarity
Metal bindingi128 – 1281Iron By similarity

GO - Molecular functioni

  1. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:VV1_1608
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172S-ribosylhomocysteine lyaseUniRule annotation
PRO_0000172277Add
BLAST

Proteomic databases

PRIDEiQ9AHK1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV1_1608.

Structurei

3D structure databases

ProteinModelPortaliQ9AHK1.
SMRiQ9AHK1. Positions 3-161.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

eggNOGiCOG1854.
HOGENOMiHOG000040371.
KOiK07173.
OMAiAWLASMN.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AHK1-1 [UniParc]FASTAAdd to Basket

« Hide

MPLLDSFTVD HTRMHAPAVR VAKTMQTPKG DTITVFDLRF TAPNKDILSE    50
KGIHTLEHLY AGFMRKHLNG ASVEIIDISP MGCRTGFYMS LIGAPSEQDV 100
ASAWTASMED VLKVESQNKI PELNEYQCGT AAMHSLDEAK QIAQNILAAG 150
ISVNKNDELA LPEAMLKELK VD 172
Length:172
Mass (Da):18,900
Last modified:June 1, 2001 - v1
Checksum:iFD16AC0DD7669CB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305637 Genomic DNA. Translation: AAK15466.1.
AF401230 Genomic DNA. Translation: AAK95612.1.
AE016795 Genomic DNA. Translation: AAO10029.1.
RefSeqiNP_760502.1. NC_004459.3.
WP_011079537.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10029; AAO10029; VV1_1608.
GeneIDi1178526.
KEGGivvu:VV1_1608.
PATRICi20160005. VBIVibVul94426_1488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305637 Genomic DNA. Translation: AAK15466.1 .
AF401230 Genomic DNA. Translation: AAK95612.1 .
AE016795 Genomic DNA. Translation: AAO10029.1 .
RefSeqi NP_760502.1. NC_004459.3.
WP_011079537.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q9AHK1.
SMRi Q9AHK1. Positions 3-161.
ModBasei Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1608.

Proteomic databases

PRIDEi Q9AHK1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO10029 ; AAO10029 ; VV1_1608 .
GeneIDi 1178526.
KEGGi vvu:VV1_1608.
PATRICi 20160005. VBIVibVul94426_1488.

Phylogenomic databases

eggNOGi COG1854.
HOGENOMi HOG000040371.
KOi K07173.
OMAi AWLASMN.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci VVUL216895:GIYM-1419-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LuxS quorum sensing system regulates virulence of Vibrio vulnificus."
    Kim S.Y., Lee S.E., Kim Y.R., Jin Y.S., Ryu P.Y., Chung S.S., Rhee J.H.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "LuxS quorum sensing system in Vibrio vulnificus ATCC29307."
    Baek C.H., Park D.K., Lee K.E., Kim Y.T., Hwang W., Kim K.S.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29307 / CDC A8694.
  3. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiLUXS_VIBVU
AccessioniPrimary (citable) accession number: Q9AHK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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