ID   CPSB1_STRPN             Reviewed;         243 AA.
AC   Q9AHD4;
DT   01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Tyrosine-protein phosphatase cpsB;
DE            EC=3.1.3.48;
GN   Name=cpsB; Synonyms=wzh; OrderedLocusNames=SP_0347;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WCH35 / Serotype 4;
RX   MEDLINE=21116929; PubMed=11179285;
RX   DOI=10.1128/IAI.69.3.1244-1255.2001;
RA   Jiang S.-M., Wang L., Reeves P.R.;
RT   "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8,
RT   and 18C capsular polysaccharide gene clusters.";
RL   Infect. Immun. 69:1244-1255(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   MEDLINE=21357209; PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T.,
RA   Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C.,
RA   Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Dephosphorylates cpsD. Involved in the regulation of
CC       capsular polysaccharide biosynthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the cpsB/capC family.
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DR   EMBL; AF316639; AAK20667.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK74520.1; -; Genomic_DNA.
DR   PIR; G95040; G95040.
DR   RefSeq; NP_344880.1; -.
DR   GeneID; 930166; -.
DR   GenomeReviews; AE005672_GR; SP_0347.
DR   KEGG; spn:SP_0347; -.
DR   TIGR; SP_0347; -.
DR   HOGENOM; Q9AHD4; -.
DR   OMA; Q9AHD4; ITPVIAH.
DR   BRENDA; 3.1.3.48; 600.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016667; Caps_polysacc_synth_CpsB/CapC.
DR   InterPro; IPR004013; PHP_C.
DR   Pfam; PF02811; PHP; 1.
DR   PIRSF; PIRSF016557; Caps_synth_CpsB; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Complete proteome;
KW   Exopolysaccharide synthesis; Hydrolase; Manganese;
KW   Protein phosphatase.
FT   CHAIN         1    243       Tyrosine-protein phosphatase cpsB.
FT                                /FTId=PRO_0000057891.
SQ   SEQUENCE   243 AA;  28131 MW;  1171C4A506FDE0D5 CRC64;
     MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET PEEKIAENFL
     QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN DSRYALIEFS MNTPYRDIHS
     ALSKILMLGI TPVIAHIERY DALENNEKRV RELIDMGCYT QVNSSHVLKP KLFGERYKFM
     KKRAQYFLEQ DLVHVIASDM HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD
     QLI
//