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Q9AHD4

- CPSB_STRPN

UniProt

Q9AHD4 - CPSB_STRPN

Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. manganese ion binding Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-353-MONOMER.
    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
    Gene namesi
    Name:cpsB
    Synonyms:wzh
    Ordered Locus Names:SP_0347
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057891Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi170187.SP_0347.

    Structurei

    Secondary structure

    243
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 33
    Beta strandi12 – 154
    Helixi19 – 3113
    Beta strandi34 – 385
    Beta strandi42 – 443
    Turni45 – 473
    Helixi52 – 6918
    Beta strandi74 – 763
    Beta strandi80 – 823
    Helixi87 – 926
    Helixi99 – 1013
    Beta strandi102 – 1087
    Helixi115 – 12612
    Turni127 – 1293
    Beta strandi131 – 1344
    Helixi137 – 1393
    Helixi141 – 1433
    Helixi147 – 1559
    Beta strandi159 – 1635
    Helixi164 – 1674
    Beta strandi172 – 1743
    Helixi178 – 18912
    Beta strandi194 – 1974
    Beta strandi203 – 2064
    Helixi210 – 22112
    Helixi223 – 2308
    Helixi232 – 2387

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WJDX-ray2.80A1-243[»]
    2WJEX-ray1.90A1-243[»]
    2WJFX-ray2.22A1-243[»]
    3QY8X-ray2.00A1-243[»]
    ProteinModelPortaliQ9AHD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9AHD4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsB/CapC family.Curated

    Phylogenomic databases

    eggNOGiCOG4464.
    HOGENOMiHOG000007624.
    KOiK01104.
    OMAiTPHTLNG.
    OrthoDBiEOG6PKFDD.

    Family and domain databases

    InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
    IPR004013. PHP_C.
    [Graphical view]
    PfamiPF02811. PHP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9AHD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET    50
    PEEKIAENFL QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN 100
    DSRYALIEFS MNTPYRDIHS ALSKILMLGI TPVIAHIERY DALENNEKRV 150
    RELIDMGCYT QVNSSHVLKP KLFGERYKFM KKRAQYFLEQ DLVHVIASDM 200
    HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI 243
    Length:243
    Mass (Da):28,131
    Last modified:June 1, 2001 - v1
    Checksum:i1171C4A506FDE0D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316639 Genomic DNA. Translation: AAK20667.1.
    AE005672 Genomic DNA. Translation: AAK74520.1.
    PIRiG95040.
    RefSeqiNP_344880.1. NC_003028.3.
    WP_000565352.1. NZ_AKVY01000001.1.

    Genome annotation databases

    EnsemblBacteriaiAAK74520; AAK74520; SP_0347.
    GeneIDi930166.
    KEGGispn:SP_0347.
    PATRICi19705035. VBIStrPne105772_0363.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316639 Genomic DNA. Translation: AAK20667.1 .
    AE005672 Genomic DNA. Translation: AAK74520.1 .
    PIRi G95040.
    RefSeqi NP_344880.1. NC_003028.3.
    WP_000565352.1. NZ_AKVY01000001.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WJD X-ray 2.80 A 1-243 [» ]
    2WJE X-ray 1.90 A 1-243 [» ]
    2WJF X-ray 2.22 A 1-243 [» ]
    3QY8 X-ray 2.00 A 1-243 [» ]
    ProteinModelPortali Q9AHD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_0347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK74520 ; AAK74520 ; SP_0347 .
    GeneIDi 930166.
    KEGGi spn:SP_0347.
    PATRICi 19705035. VBIStrPne105772_0363.

    Phylogenomic databases

    eggNOGi COG4464.
    HOGENOMi HOG000007624.
    KOi K01104.
    OMAi TPHTLNG.
    OrthoDBi EOG6PKFDD.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .
    BioCyci SPNE170187:GHGN-353-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9AHD4.

    Family and domain databases

    InterProi IPR016667. Caps_polysacc_synth_CpsB/CapC.
    IPR004013. PHP_C.
    [Graphical view ]
    Pfami PF02811. PHP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016557. Caps_synth_CpsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters."
      Jiang S.-M., Wang L., Reeves P.R.
      Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WCH35 / Serotype 4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiCPSB_STRPN
    AccessioniPrimary (citable) accession number: Q9AHD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3