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Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Mn2+By similarity

Pathway: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-353-MONOMER.
UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Synonyms:wzh
Ordered Locus Names:SP_0347
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000819.

Structurei

Secondary structure

243
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 33Combined sources
Beta strandi12 – 154Combined sources
Helixi19 – 3113Combined sources
Beta strandi34 – 385Combined sources
Beta strandi42 – 443Combined sources
Turni45 – 473Combined sources
Helixi52 – 6918Combined sources
Beta strandi74 – 763Combined sources
Beta strandi80 – 823Combined sources
Helixi87 – 926Combined sources
Helixi99 – 1013Combined sources
Beta strandi102 – 1087Combined sources
Helixi115 – 12612Combined sources
Turni127 – 1293Combined sources
Beta strandi131 – 1344Combined sources
Helixi137 – 1393Combined sources
Helixi141 – 1433Combined sources
Helixi147 – 1559Combined sources
Beta strandi159 – 1635Combined sources
Helixi164 – 1674Combined sources
Beta strandi172 – 1743Combined sources
Helixi178 – 18912Combined sources
Beta strandi194 – 1974Combined sources
Beta strandi203 – 2064Combined sources
Helixi210 – 22112Combined sources
Helixi223 – 2308Combined sources
Helixi232 – 2387Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WJDX-ray2.80A1-243[»]
2WJEX-ray1.90A1-243[»]
2WJFX-ray2.22A1-243[»]
3QY8X-ray2.00A1-243[»]
ProteinModelPortaliQ9AHD4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9AHD4.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.Curated

Phylogenomic databases

eggNOGiCOG4464.
HOGENOMiHOG000007624.
KOiK01104.
OMAiTPHTLNG.
OrthoDBiEOG6PKFDD.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AHD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET
60 70 80 90 100
PEEKIAENFL QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN
110 120 130 140 150
DSRYALIEFS MNTPYRDIHS ALSKILMLGI TPVIAHIERY DALENNEKRV
160 170 180 190 200
RELIDMGCYT QVNSSHVLKP KLFGERYKFM KKRAQYFLEQ DLVHVIASDM
210 220 230 240
HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI
Length:243
Mass (Da):28,131
Last modified:June 1, 2001 - v1
Checksum:i1171C4A506FDE0D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.
PIRiG95040.
RefSeqiNP_344880.1. NC_003028.3.
WP_000565352.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74520; AAK74520; SP_0347.
KEGGispn:SP_0347.
PATRICi19705035. VBIStrPne105772_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.
PIRiG95040.
RefSeqiNP_344880.1. NC_003028.3.
WP_000565352.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WJDX-ray2.80A1-243[»]
2WJEX-ray1.90A1-243[»]
2WJFX-ray2.22A1-243[»]
3QY8X-ray2.00A1-243[»]
ProteinModelPortaliQ9AHD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74520; AAK74520; SP_0347.
KEGGispn:SP_0347.
PATRICi19705035. VBIStrPne105772_0363.

Phylogenomic databases

eggNOGiCOG4464.
HOGENOMiHOG000007624.
KOiK01104.
OMAiTPHTLNG.
OrthoDBiEOG6PKFDD.

Enzyme and pathway databases

UniPathwayiUPA00934.
BioCyciSPNE170187:GHGN-353-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9AHD4.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters."
    Jiang S.-M., Wang L., Reeves P.R.
    Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WCH35 / Serotype 4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiCPSB_STRPN
AccessioniPrimary (citable) accession number: Q9AHD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.