Reviewed, UniProtKB/Swiss-Prot Q9AHD4 (CPSB1_STRPN)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase cpsB
    EC=3.1.3.48

Gene names

Name:	cpsB
Synonyms:	wzh
Ordered Locus Names:	SP_0347

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Dephosphorylates cpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the cpsB/capC family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 243

243

Tyrosine-protein phosphatase cpsB

PRO_0000057891

Secondary structure

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243

Helix Strand Turn

Details...

Helix

19 – 31

13

Beta strand

36 – 38

3

Beta strand

42 – 44

3

Helix

52 – 69

18

Beta strand

74 – 76

3

Beta strand

80 – 82

3

Helix

87 – 92

6

Helix

99 – 101

3

Beta strand

102 – 108

7

Helix

115 – 126

12

Beta strand

131 – 134

4

Helix

137 – 139

3

Helix

141 – 143

3

Helix

147 – 155

9

Beta strand

159 – 163

5

Helix

164 – 167

4

Helix

178 – 189

12

Beta strand

194 – 197

4

Helix

210 – 220

11

Helix

224 – 230

7

Helix

232 – 238

7

Sequences

	Sequence		Length	Mass (Da)
	Q9AHD4-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1171C4A506FDE0D5	FASTA	243	28,131
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET PEEKIAENFL 70 80 90 100 110 120 QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN DSRYALIEFS MNTPYRDIHS 130 140 150 160 170 180 ALSKILMLGI TPVIAHIERY DALENNEKRV RELIDMGCYT QVNSSHVLKP KLFGERYKFM 190 200 210 220 230 240 KKRAQYFLEQ DLVHVIASDM HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters." Jiang S.-M., Wang L., Reeves P.R. Infect. Immun. 69:1244-1255(2001) [PubMed: 11179285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WCH35 / Serotype 4.
[2]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.

PIR

G95040.

RefSeq

NP_344880.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WJD	X-ray	2.80	A	1-243	[»]
2WJE	X-ray	1.90	A	1-243	[»]
2WJF	X-ray	2.22	A	1-243	[»]

ModBase

Search...

Genome annotation databases

GeneID

930166.

GenomeReviews

Gene locus SP_0347 in contig AE005672_GR.

KEGG

spn:SP_0347.

TIGR

SP_0347.

Phylogenomic databases

HOGENOM

HBG288653.

OMA

CYTQVNS.

Enzyme and pathway databases

BRENDA

3.1.3.48. 600.

Family and domain databases

InterPro

IPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]

Pfam

PF02811. PHP. 1 hit.
[Graphical view]

PIRSF

PIRSF016557. Caps_synth_CpsB. 1 hit.

ProtoNet

Search...

Entry information

Entry name

CPSB1_STRPN

Accession

Primary (citable) accession number: Q9AHD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	June 1, 2001
Last modified:	January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)