Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Mn2+By similarity

Pathwayi: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Synonyms:wzh
Ordered Locus Names:SP_0347
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578911 – 243Tyrosine-protein phosphatase CpsBAdd BLAST243

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000819.

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 3Combined sources3
Beta strandi12 – 15Combined sources4
Helixi19 – 31Combined sources13
Beta strandi34 – 38Combined sources5
Beta strandi42 – 44Combined sources3
Turni45 – 47Combined sources3
Helixi52 – 69Combined sources18
Beta strandi74 – 76Combined sources3
Beta strandi80 – 82Combined sources3
Helixi87 – 92Combined sources6
Helixi99 – 101Combined sources3
Beta strandi102 – 108Combined sources7
Helixi115 – 126Combined sources12
Turni127 – 129Combined sources3
Beta strandi131 – 134Combined sources4
Helixi137 – 139Combined sources3
Helixi141 – 143Combined sources3
Helixi147 – 155Combined sources9
Beta strandi159 – 163Combined sources5
Helixi164 – 167Combined sources4
Beta strandi172 – 174Combined sources3
Helixi178 – 189Combined sources12
Beta strandi194 – 197Combined sources4
Beta strandi203 – 206Combined sources4
Helixi210 – 221Combined sources12
Helixi223 – 230Combined sources8
Helixi232 – 238Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WJDX-ray2.80A1-243[»]
2WJEX-ray1.90A1-243[»]
2WJFX-ray2.22A1-243[»]
3QY8X-ray2.00A1-243[»]
ProteinModelPortaliQ9AHD4.
SMRiQ9AHD4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9AHD4.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.Curated

Phylogenomic databases

eggNOGiENOG4108RB3. Bacteria.
COG4464. LUCA.
HOGENOMiHOG000007624.
KOiK01104.
OMAiVHPERNS.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR032466. Metal_Hydrolase.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AHD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET
60 70 80 90 100
PEEKIAENFL QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN
110 120 130 140 150
DSRYALIEFS MNTPYRDIHS ALSKILMLGI TPVIAHIERY DALENNEKRV
160 170 180 190 200
RELIDMGCYT QVNSSHVLKP KLFGERYKFM KKRAQYFLEQ DLVHVIASDM
210 220 230 240
HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI
Length:243
Mass (Da):28,131
Last modified:June 1, 2001 - v1
Checksum:i1171C4A506FDE0D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.
PIRiG95040.
RefSeqiWP_000565352.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74520; AAK74520; SP_0347.
KEGGispn:SP_0347.
PATRICi19705035. VBIStrPne105772_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.
PIRiG95040.
RefSeqiWP_000565352.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WJDX-ray2.80A1-243[»]
2WJEX-ray1.90A1-243[»]
2WJFX-ray2.22A1-243[»]
3QY8X-ray2.00A1-243[»]
ProteinModelPortaliQ9AHD4.
SMRiQ9AHD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74520; AAK74520; SP_0347.
KEGGispn:SP_0347.
PATRICi19705035. VBIStrPne105772_0363.

Phylogenomic databases

eggNOGiENOG4108RB3. Bacteria.
COG4464. LUCA.
HOGENOMiHOG000007624.
KOiK01104.
OMAiVHPERNS.

Enzyme and pathway databases

UniPathwayiUPA00934.

Miscellaneous databases

EvolutionaryTraceiQ9AHD4.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR032466. Metal_Hydrolase.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPSB_STRPN
AccessioniPrimary (citable) accession number: Q9AHD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.