Reviewed, UniProtKB/Swiss-Prot Q9AHD4 (CPSB1_STRPN)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase cpsB
    EC=3.1.3.48

Gene names

Name:	cpsB
Synonyms:	wzh
Ordered Locus Names:	SP_0347

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Dephosphorylates cpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the cpsB/capC family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Tyrosine-protein phosphatase cpsB		PRO_0000057891

Sequences

	Sequence		Length	Mass (Da)
	Q9AHD4-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1171C4A506FDE0D5	FASTA	243	28,131
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET PEEKIAENFL 70 80 90 100 110 120 QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN DSRYALIEFS MNTPYRDIHS 130 140 150 160 170 180 ALSKILMLGI TPVIAHIERY DALENNEKRV RELIDMGCYT QVNSSHVLKP KLFGERYKFM 190 200 210 220 230 240 KKRAQYFLEQ DLVHVIASDM HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters." Jiang S.-M., Wang L., Reeves P.R. Infect. Immun. 69:1244-1255(2001) [PubMed: 11179285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WCH35 / Serotype 4.
[2]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF316639 Genomic DNA. Translation: AAK20667.1. AE005672 Genomic DNA. Translation: AAK74520.1.
PIR	G95040.
RefSeq	NP_344880.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	930166.
GenomeReviews	Gene locus SP_0347 in contig AE005672_GR.
KEGG	spn:SP_0347.
TIGR	SP_0347.
Phylogenomic databases
HOGENOM	Q9AHD4.
OMA	Q9AHD4. ITPVIAH.
Enzyme and pathway databases
BRENDA	3.1.3.48. 600.
Family and domain databases
InterPro	IPR016667. Caps_polysacc_synth_CpsB/CapC. IPR004013. PHP_C. [Graphical view]
Pfam	PF02811. PHP. 1 hit. [Graphical view]
PIRSF	PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSB1_STRPN

Accession

Primary (citable) accession number: Q9AHD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)