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Q9AHD4

- CPSB_STRPN

UniProt

Q9AHD4 - CPSB_STRPN

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Protein

Tyrosine-protein phosphatase CpsB

Gene
cpsB, wzh, SP_0347
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. manganese ion binding Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-353-MONOMER.
UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Synonyms:wzh
Ordered Locus Names:SP_0347
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0347.

Structurei

Secondary structure

243
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 33
Beta strandi12 – 154
Helixi19 – 3113
Beta strandi34 – 385
Beta strandi42 – 443
Turni45 – 473
Helixi52 – 6918
Beta strandi74 – 763
Beta strandi80 – 823
Helixi87 – 926
Helixi99 – 1013
Beta strandi102 – 1087
Helixi115 – 12612
Turni127 – 1293
Beta strandi131 – 1344
Helixi137 – 1393
Helixi141 – 1433
Helixi147 – 1559
Beta strandi159 – 1635
Helixi164 – 1674
Beta strandi172 – 1743
Helixi178 – 18912
Beta strandi194 – 1974
Beta strandi203 – 2064
Helixi210 – 22112
Helixi223 – 2308
Helixi232 – 2387

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WJDX-ray2.80A1-243[»]
2WJEX-ray1.90A1-243[»]
2WJFX-ray2.22A1-243[»]
3QY8X-ray2.00A1-243[»]
ProteinModelPortaliQ9AHD4.

Miscellaneous databases

EvolutionaryTraceiQ9AHD4.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.

Phylogenomic databases

eggNOGiCOG4464.
HOGENOMiHOG000007624.
KOiK01104.
OMAiTPHTLNG.
OrthoDBiEOG6PKFDD.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AHD4-1 [UniParc]FASTAAdd to Basket

« Hide

MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET    50
PEEKIAENFL QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN 100
DSRYALIEFS MNTPYRDIHS ALSKILMLGI TPVIAHIERY DALENNEKRV 150
RELIDMGCYT QVNSSHVLKP KLFGERYKFM KKRAQYFLEQ DLVHVIASDM 200
HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI 243
Length:243
Mass (Da):28,131
Last modified:June 1, 2001 - v1
Checksum:i1171C4A506FDE0D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.
PIRiG95040.
RefSeqiNP_344880.1. NC_003028.3.
WP_000565352.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74520; AAK74520; SP_0347.
GeneIDi930166.
KEGGispn:SP_0347.
PATRICi19705035. VBIStrPne105772_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316639 Genomic DNA. Translation: AAK20667.1 .
AE005672 Genomic DNA. Translation: AAK74520.1 .
PIRi G95040.
RefSeqi NP_344880.1. NC_003028.3.
WP_000565352.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WJD X-ray 2.80 A 1-243 [» ]
2WJE X-ray 1.90 A 1-243 [» ]
2WJF X-ray 2.22 A 1-243 [» ]
3QY8 X-ray 2.00 A 1-243 [» ]
ProteinModelPortali Q9AHD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK74520 ; AAK74520 ; SP_0347 .
GeneIDi 930166.
KEGGi spn:SP_0347.
PATRICi 19705035. VBIStrPne105772_0363.

Phylogenomic databases

eggNOGi COG4464.
HOGENOMi HOG000007624.
KOi K01104.
OMAi TPHTLNG.
OrthoDBi EOG6PKFDD.

Enzyme and pathway databases

UniPathwayi UPA00934 .
BioCyci SPNE170187:GHGN-353-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9AHD4.

Family and domain databases

InterProi IPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view ]
Pfami PF02811. PHP. 1 hit.
[Graphical view ]
PIRSFi PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters."
    Jiang S.-M., Wang L., Reeves P.R.
    Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WCH35 / Serotype 4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiCPSB_STRPN
AccessioniPrimary (citable) accession number: Q9AHD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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