Q9AHD4 (CPSB_STRPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase CpsB
EC=3.1.3.48

Gene names

Name:	cpsB
Synonyms:	wzh
Ordered Locus Names:	SP_0347

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]

Taxonomic identifier

170187 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the CpsB/CapC family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	manganese ion binding Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 243

243

Tyrosine-protein phosphatase CpsB

PRO_0000057891

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

243

Helix Strand Turn

Details...

Beta strand

1 – 3

3

Beta strand

12 – 15

4

Helix

19 – 31

13

Beta strand

34 – 38

5

Beta strand

42 – 44

3

Turn

45 – 47

3

Helix

52 – 69

18

Beta strand

74 – 76

3

Beta strand

80 – 82

3

Helix

87 – 92

6

Helix

99 – 101

3

Beta strand

102 – 108

7

Helix

115 – 126

12

Turn

127 – 129

3

Beta strand

131 – 134

4

Helix

137 – 139

3

Helix

141 – 143

3

Helix

147 – 155

9

Beta strand

159 – 163

5

Helix

164 – 167

4

Beta strand

172 – 174

3

Helix

178 – 189

12

Beta strand

194 – 197

4

Beta strand

203 – 206

4

Helix

210 – 221

12

Helix

223 – 230

8

Helix

232 – 238

7

Sequences

	Sequence		Length	Mass (Da)
	Q9AHD4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1171C4A506FDE0D5	FASTA	243	28,131
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET PEEKIAENFL 70 80 90 100 110 120 QVREIAKEVA SDLVIAYGAE IYYTPDVLDK LEKKRIPTLN DSRYALIEFS MNTPYRDIHS 130 140 150 160 170 180 ALSKILMLGI TPVIAHIERY DALENNEKRV RELIDMGCYT QVNSSHVLKP KLFGERYKFM 190 200 210 220 230 240 KKRAQYFLEQ DLVHVIASDM HNLDGRPPHM AEAYDLVTQK YGEAKAQELF IDNPRKIVMD QLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters." Jiang S.-M., Wang L., Reeves P.R. Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WCH35 / Serotype 4.
[2]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF316639 Genomic DNA. Translation: AAK20667.1.
AE005672 Genomic DNA. Translation: AAK74520.1.

PIR

G95040.

RefSeq

NP_344880.1. NC_003028.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WJD	X-ray	2.80	A	1-243	[»]
2WJE	X-ray	1.90	A	1-243	[»]
2WJF	X-ray	2.22	A	1-243	[»]
3QY8	X-ray	2.00	A	1-243	[»]

ProteinModelPortal

Q9AHD4.

ModBase

Search...

Protein-protein interaction databases

STRING

170187.SP_0347.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAK74520; AAK74520; SP_0347.

GeneID

930166.

KEGG

spn:SP_0347.

PATRIC

19705035. VBIStrPne105772_0363.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG4464.

HOGENOM

HOG000007624.

KO

K01104.

OMA

MIDVHSH.

ProtClustDB

CLSK883942.

Enzyme and pathway databases

UniPathway

UPA00934.

Family and domain databases

InterPro

IPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]

Pfam

PF02811. PHP. 1 hit.
[Graphical view]

PIRSF

PIRSF016557. Caps_synth_CpsB. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q9AHD4.

Entry information

Entry name

CPSB_STRPN

Accession

Primary (citable) accession number: Q9AHD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program