Reviewed, UniProtKB/Swiss-Prot Q9AHD2 (CPSD1_STRPN)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein kinase cpsD
    EC=2.7.10.2

Gene names

Name:	cpsD
Synonyms:	wze
Ordered Locus Names:	SP_0349

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of cpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Enzyme regulation	Dephosphorylated and activated by cpsB By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Post-translational modification	Autophosphorylated By similarity.
Sequence similarities	Belongs to the cpsD/capB family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro cobalamin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cobyrinic acid a,c-diamide synthase activity Inferred from electronic annotation. Source: InterPro enzyme regulator activity Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Tyrosine-protein kinase cpsD		PRO_0000217239

Sequences

	Sequence		Length	Mass (Da)
	Q9AHD2-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 79D4882D336943B8	FASTA	227	24,887
	10 20 30 40 50 60 MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT TTSINIAWSF 70 80 90 100 110 120 ARAGYKTLLI DGDTRNSVML GVFKSREKIT GLTEFLSGTA DLSHGLCDTN IENLFVVQSG 130 140 150 160 170 180 SVSPNPTALL QSKNFNDMIE TLRKYFDYII IDTPPIGIVI DAAIITQKCD ASILVTATGE 190 200 210 220 ANKRDIQKAK QQLKQTGKLF LGVVLNKLDI SVNKYGVYGS YGNYGKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters." Jiang S.-M., Wang L., Reeves P.R. Infect. Immun. 69:1244-1255(2001) [PubMed: 11179285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WCH35 / Serotype 4.
[2]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF316639 Genomic DNA. Translation: AAK20669.1. AE005672 Genomic DNA. Translation: AAK74522.1.
PIR	A95041.
RefSeq	NP_344882.1.
3D structure databases
SMR	Q9AHD2. Positions 19-222.
ModBase	Search...
Genome annotation databases
GeneID	930168.
GenomeReviews	Gene locus SP_0349 in contig AE005672_GR.
KEGG	spn:SP_0349.
TIGR	SP_0349.
Phylogenomic databases
HOGENOM	HBG639890.
OMA	NAIRTNI.
Enzyme and pathway databases
BRENDA	2.7.10.2. 600.
Family and domain databases
InterPro	IPR005702. EPS_synthesis. [Graphical view]
TIGRFAMs	TIGR01007. eps_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSD1_STRPN

Accession

Primary (citable) accession number: Q9AHD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)