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Q9AHD2 (CPSD_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase CpsD

EC=2.7.10.2
Gene names
Name:cpsD
Synonyms:wze
Ordered Locus Names:SP_0349
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation

Dephosphorylated and activated by CpsB By similarity.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the CpsD/CapB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Tyrosine-protein kinase CpsD
PRO_0000217239

Sequences

Sequence LengthMass (Da)Tools
Q9AHD2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 79D4882D336943B8

FASTA22724,887
        10         20         30         40         50         60 
MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT TTSINIAWSF 

        70         80         90        100        110        120 
ARAGYKTLLI DGDTRNSVML GVFKSREKIT GLTEFLSGTA DLSHGLCDTN IENLFVVQSG 

       130        140        150        160        170        180 
SVSPNPTALL QSKNFNDMIE TLRKYFDYII IDTPPIGIVI DAAIITQKCD ASILVTATGE 

       190        200        210        220 
ANKRDIQKAK QQLKQTGKLF LGVVLNKLDI SVNKYGVYGS YGNYGKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF316639 Genomic DNA. Translation: AAK20669.1.
AE005672 Genomic DNA. Translation: AAK74522.1.
PIRA95041.
RefSeqNP_344882.1. NC_003028.3.

3D structure databases

ProteinModelPortalQ9AHD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_0349.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK74522; AAK74522; SP_0349.
GeneID930168.
KEGGspn:SP_0349.
PATRIC19705039. VBIStrPne105772_0365.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0489.
HOGENOMHOG000004334.
OMAQIMANVC.
OrthoDBEOG69D3H6.
ProtClustDBCLSK883944.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-355-MONOMER.
UniPathwayUPA00934.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01007. eps_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPSD_STRPN
AccessionPrimary (citable) accession number: Q9AHD2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways