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Q9AHD2

- CPSD_STRPN

UniProt

Q9AHD2 - CPSD_STRPN

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Protein
Tyrosine-protein kinase CpsD
Gene
cpsD, wze, SP_0349
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB By similarity.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. enzyme regulator activity Source: InterPro
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-355-MONOMER.
UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Synonyms:wze
Ordered Locus Names:SP_0349
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Tyrosine-protein kinase CpsD
PRO_0000217239Add
BLAST

Post-translational modificationi

Autophosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0349.

Structurei

3D structure databases

ProteinModelPortaliQ9AHD2.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.

Phylogenomic databases

eggNOGiCOG0489.
HOGENOMiHOG000004334.
OMAiMKELLGQ.
OrthoDBiEOG69D3H6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AHD2-1 [UniParc]FASTAAdd to Basket

« Hide

MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT    50
TTSINIAWSF ARAGYKTLLI DGDTRNSVML GVFKSREKIT GLTEFLSGTA 100
DLSHGLCDTN IENLFVVQSG SVSPNPTALL QSKNFNDMIE TLRKYFDYII 150
IDTPPIGIVI DAAIITQKCD ASILVTATGE ANKRDIQKAK QQLKQTGKLF 200
LGVVLNKLDI SVNKYGVYGS YGNYGKK 227
Length:227
Mass (Da):24,887
Last modified:June 1, 2001 - v1
Checksum:i79D4882D336943B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316639 Genomic DNA. Translation: AAK20669.1.
AE005672 Genomic DNA. Translation: AAK74522.1.
PIRiA95041.
RefSeqiNP_344882.1. NC_003028.3.
WP_001142502.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74522; AAK74522; SP_0349.
GeneIDi930168.
KEGGispn:SP_0349.
PATRICi19705039. VBIStrPne105772_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316639 Genomic DNA. Translation: AAK20669.1 .
AE005672 Genomic DNA. Translation: AAK74522.1 .
PIRi A95041.
RefSeqi NP_344882.1. NC_003028.3.
WP_001142502.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortali Q9AHD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK74522 ; AAK74522 ; SP_0349 .
GeneIDi 930168.
KEGGi spn:SP_0349.
PATRICi 19705039. VBIStrPne105772_0365.

Phylogenomic databases

eggNOGi COG0489.
HOGENOMi HOG000004334.
OMAi MKELLGQ.
OrthoDBi EOG69D3H6.

Enzyme and pathway databases

UniPathwayi UPA00934 .
BioCyci SPNE170187:GHGN-355-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13614. AAA_31. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01007. eps_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters."
    Jiang S.-M., Wang L., Reeves P.R.
    Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WCH35 / Serotype 4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiCPSD_STRPN
AccessioniPrimary (citable) accession number: Q9AHD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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