Q9AHD2 (CPSD_STRPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase CpsD
EC=2.7.10.2

Gene names

Name:	cpsD
Synonyms:	wze
Ordered Locus Names:	SP_0349

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]

Taxonomic identifier

170187 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Enzyme regulation	Dephosphorylated and activated by CpsB By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Post-translational modification	Autophosphorylated By similarity.
Sequence similarities	Belongs to the CpsD/CapB family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of catalytic activity Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW enzyme regulator activity Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Tyrosine-protein kinase CpsD		PRO_0000217239

Sequences

	Sequence		Length	Mass (Da)
	Q9AHD2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 79D4882D336943B8	FASTA	227	24,887
	10 20 30 40 50 60 MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT TTSINIAWSF 70 80 90 100 110 120 ARAGYKTLLI DGDTRNSVML GVFKSREKIT GLTEFLSGTA DLSHGLCDTN IENLFVVQSG 130 140 150 160 170 180 SVSPNPTALL QSKNFNDMIE TLRKYFDYII IDTPPIGIVI DAAIITQKCD ASILVTATGE 190 200 210 220 ANKRDIQKAK QQLKQTGKLF LGVVLNKLDI SVNKYGVYGS YGNYGKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters." Jiang S.-M., Wang L., Reeves P.R. Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WCH35 / Serotype 4.
[2]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF316639 Genomic DNA. Translation: AAK20669.1. AE005672 Genomic DNA. Translation: AAK74522.1.
PIR	A95041.
RefSeq	NP_344882.1. NC_003028.3.
3D structure databases
ProteinModelPortal	Q9AHD2.
ModBase	Search...
Protein-protein interaction databases
STRING	170187.SP_0349.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK74522; AAK74522; SP_0349.
GeneID	930168.
KEGG	spn:SP_0349.
PATRIC	19705039. VBIStrPne105772_0365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0489.
HOGENOM	HOG000004334.
OMA	QIMANVC.
ProtClustDB	CLSK883944.
Enzyme and pathway databases
UniPathway	UPA00934.
Family and domain databases
InterPro	IPR025669. AAA_dom. IPR005702. EPS_synthesis. [Graphical view]
Pfam	PF13614. AAA_31. 1 hit. [Graphical view]
TIGRFAMs	TIGR01007. eps_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSD_STRPN

Accession

Primary (citable) accession number: Q9AHD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program