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Q9AHD2

- CPSD_STRPN

UniProt

Q9AHD2 - CPSD_STRPN

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Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB.By similarity

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-355-MONOMER.
UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Synonyms:wze
Ordered Locus Names:SP_0349
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Tyrosine-protein kinase CpsDPRO_0000217239Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0349.

Structurei

3D structure databases

ProteinModelPortaliQ9AHD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.Curated

Phylogenomic databases

eggNOGiCOG0489.
HOGENOMiHOG000004334.
OMAiMKELLGQ.
OrthoDBiEOG69D3H6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AHD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT
60 70 80 90 100
TTSINIAWSF ARAGYKTLLI DGDTRNSVML GVFKSREKIT GLTEFLSGTA
110 120 130 140 150
DLSHGLCDTN IENLFVVQSG SVSPNPTALL QSKNFNDMIE TLRKYFDYII
160 170 180 190 200
IDTPPIGIVI DAAIITQKCD ASILVTATGE ANKRDIQKAK QQLKQTGKLF
210 220
LGVVLNKLDI SVNKYGVYGS YGNYGKK
Length:227
Mass (Da):24,887
Last modified:June 1, 2001 - v1
Checksum:i79D4882D336943B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316639 Genomic DNA. Translation: AAK20669.1.
AE005672 Genomic DNA. Translation: AAK74522.1.
PIRiA95041.
RefSeqiNP_344882.1. NC_003028.3.
WP_001142502.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74522; AAK74522; SP_0349.
GeneIDi930168.
KEGGispn:SP_0349.
PATRICi19705039. VBIStrPne105772_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316639 Genomic DNA. Translation: AAK20669.1 .
AE005672 Genomic DNA. Translation: AAK74522.1 .
PIRi A95041.
RefSeqi NP_344882.1. NC_003028.3.
WP_001142502.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortali Q9AHD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK74522 ; AAK74522 ; SP_0349 .
GeneIDi 930168.
KEGGi spn:SP_0349.
PATRICi 19705039. VBIStrPne105772_0365.

Phylogenomic databases

eggNOGi COG0489.
HOGENOMi HOG000004334.
OMAi MKELLGQ.
OrthoDBi EOG69D3H6.

Enzyme and pathway databases

UniPathwayi UPA00934 .
BioCyci SPNE170187:GHGN-355-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13614. AAA_31. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01007. eps_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters."
    Jiang S.-M., Wang L., Reeves P.R.
    Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WCH35 / Serotype 4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiCPSD_STRPN
AccessioniPrimary (citable) accession number: Q9AHD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3