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Q9AHD2

- CPSD_STRPN

UniProt

Q9AHD2 - CPSD_STRPN

Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Enzyme regulationi

    Dephosphorylated and activated by CpsB.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. enzyme regulator activity Source: InterPro
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-355-MONOMER.
    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase CpsD (EC:2.7.10.2)
    Gene namesi
    Name:cpsD
    Synonyms:wze
    Ordered Locus Names:SP_0349
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Tyrosine-protein kinase CpsDPRO_0000217239Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi170187.SP_0349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AHD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsD/CapB family.Curated

    Phylogenomic databases

    eggNOGiCOG0489.
    HOGENOMiHOG000004334.
    OMAiMKELLGQ.
    OrthoDBiEOG69D3H6.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13614. AAA_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01007. eps_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9AHD2-1 [UniParc]FASTAAdd to Basket

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    MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT    50
    TTSINIAWSF ARAGYKTLLI DGDTRNSVML GVFKSREKIT GLTEFLSGTA 100
    DLSHGLCDTN IENLFVVQSG SVSPNPTALL QSKNFNDMIE TLRKYFDYII 150
    IDTPPIGIVI DAAIITQKCD ASILVTATGE ANKRDIQKAK QQLKQTGKLF 200
    LGVVLNKLDI SVNKYGVYGS YGNYGKK 227
    Length:227
    Mass (Da):24,887
    Last modified:June 1, 2001 - v1
    Checksum:i79D4882D336943B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316639 Genomic DNA. Translation: AAK20669.1.
    AE005672 Genomic DNA. Translation: AAK74522.1.
    PIRiA95041.
    RefSeqiNP_344882.1. NC_003028.3.
    WP_001142502.1. NZ_AKVY01000001.1.

    Genome annotation databases

    EnsemblBacteriaiAAK74522; AAK74522; SP_0349.
    GeneIDi930168.
    KEGGispn:SP_0349.
    PATRICi19705039. VBIStrPne105772_0365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316639 Genomic DNA. Translation: AAK20669.1 .
    AE005672 Genomic DNA. Translation: AAK74522.1 .
    PIRi A95041.
    RefSeqi NP_344882.1. NC_003028.3.
    WP_001142502.1. NZ_AKVY01000001.1.

    3D structure databases

    ProteinModelPortali Q9AHD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_0349.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK74522 ; AAK74522 ; SP_0349 .
    GeneIDi 930168.
    KEGGi spn:SP_0349.
    PATRICi 19705039. VBIStrPne105772_0365.

    Phylogenomic databases

    eggNOGi COG0489.
    HOGENOMi HOG000004334.
    OMAi MKELLGQ.
    OrthoDBi EOG69D3H6.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .
    BioCyci SPNE170187:GHGN-355-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13614. AAA_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01007. eps_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters."
      Jiang S.-M., Wang L., Reeves P.R.
      Infect. Immun. 69:1244-1255(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WCH35 / Serotype 4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiCPSD_STRPN
    AccessioniPrimary (citable) accession number: Q9AHD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3