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Q9AGW2

- SODC_MYCPA

UniProt

Q9AGW2 - SODC_MYCPA

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Protein
Superoxide dismutase [Cu-Zn]
Gene
sodC, MAP_3921
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes By similarity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit Reviewed prediction.
Binds 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031Copper; catalytic By similarity
Metal bindingi105 – 1051Copper; catalytic By similarity
Metal bindingi145 – 1451Zinc; structural By similarity
Metal bindingi182 – 1821Copper; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-3966-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
    Gene namesi
    Name:sodC
    Ordered Locus Names:MAP_3921
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919 Reviewed prediction
    Add
    BLAST
    Chaini20 – 227208Superoxide dismutase [Cu-Zn]
    PRO_0000032839Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi20 – 201N-palmitoyl cysteine Reviewed prediction
    Lipidationi20 – 201S-diacylglycerol cysteine Reviewed prediction
    Disulfide bondi110 ↔ 221 By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi262316.MAP3921.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AGW2.
    SMRiQ9AGW2. Positions 58-227.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2032.
    KOiK04565.
    OMAiYNQTNGT.
    OrthoDBiEOG6K13RS.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9AGW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKLLPPVVL AGCVVALGAC SSPQHASSLP GTTPAVWTGS PSPSGAGAAE    50
    AAPAAAPSIT THLKAPDGTQ VATAKFEFSN GYATVTIETT ANGVLTPGFH 100
    GVHIHKVGKC EPSSVAPTGG APGDFLSAGG HFQAPGHTGE PASGDLTSLQ 150
    VRKDGSGTLV TTTDAFTMED LLGGRKTAII IHAGADNFAN IPAERYNQTN 200
    GTPGPDEMTM STGDAGKRVA CGVIGAG 227
    Length:227
    Mass (Da):22,466
    Last modified:March 15, 2004 - v2
    Checksum:iE5EE567880C00D5E
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 183ALG → GC in AAK20038. 1 Publication
    Sequence conflicti186 – 1861D → N in AAK20038. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF326234 Genomic DNA. Translation: AAK20038.1.
    AE016958 Genomic DNA. Translation: AAS06471.1.
    RefSeqiNP_962855.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS06471; AAS06471; MAP_3921.
    GeneIDi2719337.
    KEGGimpa:MAP3921.
    PATRICi18000734. VBIMycAvi108102_4173.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF326234 Genomic DNA. Translation: AAK20038.1 .
    AE016958 Genomic DNA. Translation: AAS06471.1 .
    RefSeqi NP_962855.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali Q9AGW2.
    SMRi Q9AGW2. Positions 58-227.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP3921.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS06471 ; AAS06471 ; MAP_3921 .
    GeneIDi 2719337.
    KEGGi mpa:MAP3921.
    PATRICi 18000734. VBIMycAvi108102_4173.

    Phylogenomic databases

    eggNOGi COG2032.
    KOi K04565.
    OMAi YNQTNGT.
    OrthoDBi EOG6K13RS.

    Enzyme and pathway databases

    BioCyci MAVI262316:GCQR-3966-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Identification, cloning and expression of sodC from an alkaline phosphatase gene fusion library of Mycobacterium avium subspecies paratuberculosis."
      Dupont C., Murray A.
      Microbios 106:7-19(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiSODC_MYCPA
    AccessioniPrimary (citable) accession number: Q9AGW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: March 15, 2004
    Last modified: July 9, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks three conserved histidine residues that bind copper and zinc.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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