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Q9AGW2 (SODC_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Cu-Zn]

EC=1.15.1.1
Gene names
Name:sodC
Ordered Locus Names:MAP_3921
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 copper ion per subunit Potential.

Binds 1 zinc ion per subunit Potential.

Subcellular location

Cell membrane; Lipid-anchor By similarity.

Sequence similarities

Belongs to the Cu-Zn superoxide dismutase family.

Caution

Lacks three conserved histidine residues that bind copper and zinc.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
   LigandCopper
Metal-binding
Zinc
   Molecular functionAntioxidant
Oxidoreductase
   PTMDisulfide bond
Lipoprotein
Palmitate
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 227208Superoxide dismutase [Cu-Zn]
PRO_0000032839

Sites

Metal binding1031Copper; catalytic By similarity
Metal binding1051Copper; catalytic By similarity
Metal binding1451Zinc; structural By similarity
Metal binding1821Copper; catalytic By similarity

Amino acid modifications

Lipidation201N-palmitoyl cysteine Potential
Lipidation201S-diacylglycerol cysteine Potential
Disulfide bond110 ↔ 221 By similarity

Experimental info

Sequence conflict16 – 183ALG → GC in AAK20038. Ref.1
Sequence conflict1861D → N in AAK20038. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9AGW2 [UniParc].

Last modified March 15, 2004. Version 2.
Checksum: E5EE567880C00D5E

FASTA22722,466
        10         20         30         40         50         60 
MPKLLPPVVL AGCVVALGAC SSPQHASSLP GTTPAVWTGS PSPSGAGAAE AAPAAAPSIT 

        70         80         90        100        110        120 
THLKAPDGTQ VATAKFEFSN GYATVTIETT ANGVLTPGFH GVHIHKVGKC EPSSVAPTGG 

       130        140        150        160        170        180 
APGDFLSAGG HFQAPGHTGE PASGDLTSLQ VRKDGSGTLV TTTDAFTMED LLGGRKTAII 

       190        200        210        220 
IHAGADNFAN IPAERYNQTN GTPGPDEMTM STGDAGKRVA CGVIGAG 

« Hide

References

« Hide 'large scale' references
[1]"Identification, cloning and expression of sodC from an alkaline phosphatase gene fusion library of Mycobacterium avium subspecies paratuberculosis."
Dupont C., Murray A.
Microbios 106:7-19(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF326234 Genomic DNA. Translation: AAK20038.1.
AE016958 Genomic DNA. Translation: AAS06471.1.
RefSeqNP_962855.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ9AGW2.
SMRQ9AGW2. Positions 58-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP3921.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS06471; AAS06471; MAP_3921.
GeneID2719337.
KEGGmpa:MAP3921.
PATRIC18000734. VBIMycAvi108102_4173.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2032.
KOK04565.
OMAYNQTNGT.
OrthoDBEOG6K13RS.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-3966-MONOMER.

Family and domain databases

Gene3D2.60.40.200. 1 hit.
InterProIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSPR00068. CUZNDISMTASE.
SUPFAMSSF49329. SSF49329. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODC_MYCPA
AccessionPrimary (citable) accession number: Q9AGW2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 15, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families