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Q9AGH8

- Q9AGH8_ALCFA

UniProt

Q9AGH8 - Q9AGH8_ALCFA

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Protein
Submitted name: D-aminoacylase
Gene
N/A
Organism
Alcaligenes faecalis
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Cadmium; via tele nitrogenImported
Metal bindingi68 – 681Copper; via tele nitrogenImported
Metal bindingi68 – 681Zinc 1; via tele nitrogenImported
Metal bindingi70 – 701Cadmium; via tele nitrogenImported
Metal bindingi70 – 701Copper; via tele nitrogenImported
Metal bindingi70 – 701Zinc 1; via tele nitrogenImported
Metal bindingi78 – 781Zinc 2; via tele nitrogenImported
Metal bindingi97 – 971CopperImported
Metal bindingi97 – 971Zinc 1
Metal bindingi97 – 971Zinc 3Imported
Metal bindingi118 – 1181Zinc 2Imported
Metal bindingi177 – 1771Zinc 4Imported
Metal bindingi202 – 2021Zinc 5Imported
Metal bindingi206 – 2061Zinc 5Imported
Metal bindingi214 – 2141Zinc 4; via tele nitrogenImported
Metal bindingi221 – 2211Zinc 3; via pros nitrogenImported
Metal bindingi251 – 2511Zinc 3; via tele nitrogenImported
Metal bindingi322 – 3221Zinc 6Imported
Metal bindingi326 – 3261Zinc 6Imported
Metal bindingi367 – 3671CadmiumImported
Metal bindingi367 – 3671Zinc 1Imported

GO - Molecular functioni

  1. N-acyl-D-amino-acid deacylase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

CadmiumImported, CopperImported, Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
D-aminoacylaseImported (EC:3.5.1.81Imported)
OrganismiAlcaligenes faecalisImported
Taxonomic identifieri511 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAlcaligenes

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M7JX-ray1.50A1-484[»]
1RJPX-ray1.80A1-484[»]
1RJQX-ray1.80A1-484[»]
1RJRX-ray2.10A1-484[»]
1RK5X-ray1.80A1-484[»]
1RK6X-ray1.43A1-484[»]
1V4YX-ray1.65A1-484[»]
1V51X-ray1.60A1-484[»]
ProteinModelPortaliQ9AGH8.
SMRiQ9AGH8. Positions 8-481.

Miscellaneous databases

EvolutionaryTraceiQ9AGH8.

Family & Domainsi

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
3.30.1490.130. 1 hit.
InterProiIPR013108. Amidohydro_3.
IPR023100. D-aminoacylase_insert_dom.
IPR012855. D_aminoacylase_C.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamiPF07969. Amidohydro_3. 2 hits.
PF07908. D-aminoacyl_C. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9AGH8-1 [UniParc]FASTAAdd to Basket

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MSQPDATPFD YILSGGTVID GTNAPGRLAD VGVRGDRIAA VGDLSASSAR    50
RRIDVAGKVV SPGFIDSHTH DDNYLLKHRD MTPKISQGVT TVVTGNCGIS 100
LAPLAHANPP APLDLLDEGG SFRFARFSDY LEALRAAPPA VNAACMVGHS 150
TLRAAVMPDL RREATADEIQ AMQALADDAL ASGAIGISTG AFYPPAAHAS 200
TEEIIEVCRP LITHGGVYAT HMRDEGEHIV QALEETFRIG RELDVPVVIS 250
HHKVMGKLNF GRSKETLALI EAAMASQDVS LDAYPYVAGS TMLKQDRVLL 300
AGRTLITWCK PYPELSGRDL EEIAAERGKS KYDVVPELQP AGAIYFMMDE 350
PDVQRILAFG PTMIGSDGLP HDERPHPRLW GTFPRVLGHY SRDLGLFPLE 400
TAVWKMTGLT AAKFGLAERG QVQPGYYADL VVFDPATVAD SATFEHPTER 450
AAGIHSVYVN GAAVWEDQSF TGQHAGRVLN RAGA 484
Length:484
Mass (Da):52,001
Last modified:June 1, 2001 - v1
Checksum:i634119A6CB75155E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332548 Genomic DNA. Translation: AAK15530.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332548 Genomic DNA. Translation: AAK15530.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M7J X-ray 1.50 A 1-484 [» ]
1RJP X-ray 1.80 A 1-484 [» ]
1RJQ X-ray 1.80 A 1-484 [» ]
1RJR X-ray 2.10 A 1-484 [» ]
1RK5 X-ray 1.80 A 1-484 [» ]
1RK6 X-ray 1.43 A 1-484 [» ]
1V4Y X-ray 1.65 A 1-484 [» ]
1V51 X-ray 1.60 A 1-484 [» ]
ProteinModelPortali Q9AGH8.
SMRi Q9AGH8. Positions 8-481.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q9AGH8.

Family and domain databases

Gene3Di 2.30.40.10. 2 hits.
3.30.1490.130. 1 hit.
InterProi IPR013108. Amidohydro_3.
IPR023100. D-aminoacylase_insert_dom.
IPR012855. D_aminoacylase_C.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
Pfami PF07969. Amidohydro_3. 2 hits.
PF07908. D-aminoacyl_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Structural-based mutational analysis of D-aminoacylase from Alcaligenes faecalis DA1."
    Hsu C.S., Lai W.L., Chang W.W., Liaw S.H., Tsai Y.C.
    Protein Sci. 11:2545-2550(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism."
    Liaw S.H., Chen S.J., Ko T.P., Hsu C.S., Chen C.J., Wang A.H., Tsai Y.C.
    J. Biol. Chem. 278:4957-4962(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH ZINC.
  3. "The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation."
    Lai W.L., Chou L.Y., Ting C.Y., Kirby R., Tsai Y.C., Wang A.H., Liaw S.H.
    J. Biol. Chem. 279:13962-13967(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) IN COMPLEX WITH CADMIUM; COPPER AND ZINC.

Entry informationi

Entry nameiQ9AGH8_ALCFA
AccessioniPrimary (citable) accession number: Q9AGH8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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