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Q9AGH8

- Q9AGH8_ALCFA

UniProt

Q9AGH8 - Q9AGH8_ALCFA

Protein
Submitted name:

D-aminoacylase

Gene
N/A
Organism
Alcaligenes faecalis
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Copper; via tele nitrogenImported
    Metal bindingi68 – 681Zinc 1; via tele nitrogenImported
    Metal bindingi70 – 701Copper; via tele nitrogenImported
    Metal bindingi70 – 701Zinc 1; via tele nitrogenImported
    Metal bindingi78 – 781Zinc 2; via tele nitrogenImported
    Metal bindingi97 – 971CopperImported
    Metal bindingi97 – 971Zinc 1Imported
    Metal bindingi97 – 971Zinc 3Imported
    Metal bindingi118 – 1181Zinc 2Imported
    Metal bindingi177 – 1771Zinc 4Imported
    Metal bindingi202 – 2021Zinc 5Imported
    Metal bindingi206 – 2061Zinc 5Imported
    Metal bindingi214 – 2141Zinc 4; via tele nitrogenImported
    Metal bindingi221 – 2211Zinc 3; via pros nitrogenImported
    Metal bindingi251 – 2511Zinc 3; via tele nitrogenImported
    Metal bindingi322 – 3221Zinc 6Imported
    Metal bindingi326 – 3261Zinc 6Imported
    Metal bindingi367 – 3671Zinc 1

    GO - Molecular functioni

    1. N-acyl-D-amino-acid deacylase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    HydrolaseImported

    Keywords - Ligandi

    CopperImported, Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D-aminoacylaseImported (EC:3.5.1.81Imported)
    OrganismiAlcaligenes faecalisImported
    Taxonomic identifieri511 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAlcaligenes

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1M7JX-ray1.50A1-484[»]
    1RJPX-ray1.80A1-484[»]
    1RJQX-ray1.80A1-484[»]
    1RJRX-ray2.10A1-484[»]
    1RK5X-ray1.80A1-484[»]
    1RK6X-ray1.43A1-484[»]
    1V4YX-ray1.65A1-484[»]
    1V51X-ray1.60A1-484[»]
    ProteinModelPortaliQ9AGH8.
    SMRiQ9AGH8. Positions 8-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9AGH8.

    Family & Domainsi

    Family and domain databases

    Gene3Di2.30.40.10. 2 hits.
    3.30.1490.130. 1 hit.
    InterProiIPR013108. Amidohydro_3.
    IPR023100. D-aminoacylase_insert_dom.
    IPR012855. D_aminoacylase_C.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    PfamiPF07969. Amidohydro_3. 2 hits.
    PF07908. D-aminoacyl_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9AGH8-1 [UniParc]FASTAAdd to Basket

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    MSQPDATPFD YILSGGTVID GTNAPGRLAD VGVRGDRIAA VGDLSASSAR    50
    RRIDVAGKVV SPGFIDSHTH DDNYLLKHRD MTPKISQGVT TVVTGNCGIS 100
    LAPLAHANPP APLDLLDEGG SFRFARFSDY LEALRAAPPA VNAACMVGHS 150
    TLRAAVMPDL RREATADEIQ AMQALADDAL ASGAIGISTG AFYPPAAHAS 200
    TEEIIEVCRP LITHGGVYAT HMRDEGEHIV QALEETFRIG RELDVPVVIS 250
    HHKVMGKLNF GRSKETLALI EAAMASQDVS LDAYPYVAGS TMLKQDRVLL 300
    AGRTLITWCK PYPELSGRDL EEIAAERGKS KYDVVPELQP AGAIYFMMDE 350
    PDVQRILAFG PTMIGSDGLP HDERPHPRLW GTFPRVLGHY SRDLGLFPLE 400
    TAVWKMTGLT AAKFGLAERG QVQPGYYADL VVFDPATVAD SATFEHPTER 450
    AAGIHSVYVN GAAVWEDQSF TGQHAGRVLN RAGA 484
    Length:484
    Mass (Da):52,001
    Last modified:June 1, 2001 - v1
    Checksum:i634119A6CB75155E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332548 Genomic DNA. Translation: AAK15530.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332548 Genomic DNA. Translation: AAK15530.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1M7J X-ray 1.50 A 1-484 [» ]
    1RJP X-ray 1.80 A 1-484 [» ]
    1RJQ X-ray 1.80 A 1-484 [» ]
    1RJR X-ray 2.10 A 1-484 [» ]
    1RK5 X-ray 1.80 A 1-484 [» ]
    1RK6 X-ray 1.43 A 1-484 [» ]
    1V4Y X-ray 1.65 A 1-484 [» ]
    1V51 X-ray 1.60 A 1-484 [» ]
    ProteinModelPortali Q9AGH8.
    SMRi Q9AGH8. Positions 8-481.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9AGH8.

    Family and domain databases

    Gene3Di 2.30.40.10. 2 hits.
    3.30.1490.130. 1 hit.
    InterProi IPR013108. Amidohydro_3.
    IPR023100. D-aminoacylase_insert_dom.
    IPR012855. D_aminoacylase_C.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    Pfami PF07969. Amidohydro_3. 2 hits.
    PF07908. D-aminoacyl_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Structural-based mutational analysis of D-aminoacylase from Alcaligenes faecalis DA1."
      Hsu C.S., Lai W.L., Chang W.W., Liaw S.H., Tsai Y.C.
      Protein Sci. 11:2545-2550(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism."
      Liaw S.H., Chen S.J., Ko T.P., Hsu C.S., Chen C.J., Wang A.H., Tsai Y.C.
      J. Biol. Chem. 278:4957-4962(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH ZINC.
    3. "The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation."
      Lai W.L., Chou L.Y., Ting C.Y., Kirby R., Tsai Y.C., Wang A.H., Liaw S.H.
      J. Biol. Chem. 279:13962-13967(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC.

    Entry informationi

    Entry nameiQ9AGH8_ALCFA
    AccessioniPrimary (citable) accession number: Q9AGH8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3